Abstract: A measurement and testing system is disclosed herein. The measurement and testing system includes a first measurement device and a second measurement device and a data processing device operatively coupled to the first measurement device and the second measurement device. In one or more embodiments, the data processing device is configured to synchronize each of a first plurality of data values from the first measurement device with each of a second plurality of data values from the second measurement device by determining which first timestamps associated with the first plurality of data values correspond to second timestamps associated with the second plurality of data values. In one or more other embodiments, the data processing device is configured to compute time-delayed values of one or more first measurement signals from a first measurement device using a predetermined time delay.

Abstract: A method for addressing tactical situations via tactical devices may include (i) identifying at least one wearable device that monitors at least one biomarker of a user wearing the at least one wearable device during a span of time while carrying out daily activities, (ii) receiving, by a server, information about activity of the at least one biomarker monitored by the at least one wearable device during the span of time, (iii) determining that the activity of the at least one biomarker during the span of time includes an early indication of an illness, and (iv) transmitting an alert about the early indication of the illness detected by the at least one wearable device. Various other systems, and methods are also disclosed.

Abstract: In some aspects of the present disclosure, methods of detecting coincident sample events are provided. The methods include receiving a first set of signal data representing detected signals from a flow cytometer system; detecting, with a peak detection module, one or more peaks within the signal data; and cancelling, with a successive cancellation module, one or more individual sample events from the signal data at corresponding time indexes, wherein the cancellation of more than one individual sample event is successive. Devices and system related thereto are also provided.

Abstract: The present invention relates to a method for determining the best combinations of at least three drugs for treating cancer, which is based on the determination of the most relevant intervention points for an individual.

Abstract: An alternating signal is applied across a nanopore of a sequencing cell, the nanopore being configured to receive a tag that is connected to a nucleotide, thereby creating a threading event. A first set of voltage data is acquired during a first portion of a plurality of cycles of the alternating signal. Each data point of the first set of voltage data corresponds to a value of a resistance of the nanopore at a different time, where the resistance of the nanopore changes when the tag is received within the nanopore. A shifted set of voltage data is determined from the first set of voltage data and difference data is computed by computing differences between data points of the first set of voltage data and corresponding data points of the shifted set of voltage data. Threading events may be identified based on the difference data.

Abstract: Methods and apparatus for predicting responsiveness to immune therapy in lung cancer. The method includes the steps of: identifying a first population of known responders and a second population of known non-responders; processing imaging data for the first and second populations using quantitative textural analysis (QTA); generating, for each member of both populations, quantitative metrics using the QTA; performing logistic regression on the quantitative metrics for both populations to yield a predictive signature expressed in the form of Y=Mx+B where x comprises mean pixel density; performing QTA on a lung cancer scan for a subsequent patient; comparing the predictive signature to one or more relevant metrics associated with the subsequent patient; and predicting responsiveness to immune therapy for the subsequent patient based on the comparison.

Abstract: Methods, systems and computer program products for detecting contagious diseases in a wildlife population using a drone are provided. Aspects include monitoring, by a drone, a geographic area and capture images of the geographic area and analyzing the captured images to identify a deceased wildlife in a region of the geographic area. Aspects also include performing increased monitoring of the region and capture supplemental images of the region using the drone and analyzing the supplemental images to identify a number of deceased wildlife in the region. Based on a determination that number of deceased wildlife in the region, greater than a threshold number, a corrective action is taken.

Abstract: The present invention provides an apparatus and a method for detecting the presence of and/or determining the amount of a label-free microRNA using an atomic force microscope. The method is extremely selective and/or ultrasensitive. In particular, the present invention provides a cantilever comprising a probe that selectively binds to a double strand of DNA/RNA hybrid complex. The probe comprises a hybrid binding domain (HBD) or a variant thereof.

Abstract: A system and method of maintaining social distancing guidelines with nearby persons allows a user to receive a notification when other people enter within a perimeter around them. A wearable device, especially a belt, equipped with infrared (IR) sensors detects heat signatures of nearby objects. The wearable device subsequently relays this information to the user's mobile electronic device, immediately notifying the user of persons within the predefined radius. The wearable device further differentiates between different distinctly human heat signatures, using artificial intelligence to determine whether a nearby person has the elevated internal temperature that could be attributed to COVID-19, or if the person within the preset radius is asymptomatic. In this way, users may be alerted to dangers approaching from all sides. Users are participants in the global effort to reduce human exposure and help in reducing the distribution of cases to manageable levels.

Abstract: A method of identifying regions of malicious organic sequences includes identifying a plurality of benign snippets derived from a first sequence obtained from at least one benign organism; extracting a plurality of candidate signature snippets from a second sequence obtained from a malicious organism; determining, for each of the plurality of candidate signature snippets, whether the candidate signature snippet matches at least one of the plurality of benign snippets; and responsive to the candidate signature snippet not matching the at least one of the plurality of benign snippets, identifying the candidate signature snippet as a malicious signature snippet.

Abstract: Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are provided. In some embodiments, the methods include determining expression levels for one or more genes listed in Tables 2-5, 9, 10, or 11, and/or the DE-S and/or DE-T subset of genes in PDAC cells obtained from the subject, wherein the determining provides a prognostic and/or subtype signature for the subject. Also provided are methods for classifying a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC) as having an activated stroma subtype or a normal stroma subtype of PDAC and/or a basal subtype or a classical subtype of PDAC; and methods for identifying a differential treatment strategy for a subject diagnosed with pancreatic ductal adenocarcinoma (PDAC).

Abstract: Systems and methods for isolating DNA molecules that can include the steps of: providing a transposon mutant collection, the transposon mutant collection being stored in a plurality of wells; dispatching aliquots from each well in the transposon mutant collection to a set of pools in a combinatorial pooling array that uses pool address coordinates, the aliquots being dispatched to the set of pools based on a location of the aliquots within the transposon mutant collection; constructing an amplicon library, the amplicon library including a sequencing dataset; parsing the sequencing dataset to a set of putative transposon insertion locations and pool address coordinates; calculating a likelihood for each location and pool address coordinates within the set of putative transposon insertion locations and pool address coordinates using a Bayesian inference algorithm informed by internal self-consistency; and generating a progenitor collection catalog based on location and pool address coordinates verified in the c

Abstract: The present invention relates to methods and systems for the analysis of nucleic acids present in biological samples, and more specifically, relates to clustering melt curves derived from high resolution thermal melt analysis performed on a sample of nucleic acids, the resulting clusters being usable, in one embodiment, for analyzing the sequences of nucleic acids and to classify their genotypes that are useful for determining the identity of the genotype of a nucleic acid that is present in a biological sample.

Abstract: Methods for making a synthetic gene are provided. The methods find use in optimizing a candidate gene nucleic acid sequence for expression in a selected target expression system. The method identifies stable or retained sequences in the candidate gene nucleic acid sequence, identifies disallowed sequences, develops a statistical model based on a whole genome, a partial genome, or transcriptome sequences of the target expression system, generates an optimized candidate gene nucleic acid sequence for use in the target expression system, and makes a synthetic gene comprising the optimized candidate gene nucleic acid sequence. The method allows for optimization of the candidate gene nucleic acid sequence without removing certain stable or retained sequences. Rather, the activity of these sites is positionally modulated or inactivated through upstream and downstream modifications of codons and/or sequence patterns.

Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.

Abstract: Disclosed in some examples are methods including selecting a first plurality of single gene mutants from a pool of possible single gene mutants of an organism. The first plurality of single gene mutants is less than a number of possible single mutants. A computer processor is used to iteratively select a second plurality of single gene mutants by selecting single gene mutants from the pool of possible single gene mutants that increases a sum of products of similarities between the first plurality of single gene mutants and corresponding functional relationships. The second plurality of single gene mutants is larger in number than the first plurality of single gene mutants, and wherein the second plurality of single gene mutants is less than the number of possible single gene mutants of the organism. A set of genes is outputted comprising the first and second pluralities of single gene mutants.

Abstract: The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan anchor biosynthesis protein, and providing an appropriate treatment or preventive measure, on the basis of this risk.

Abstract: To reduce errors in determining a degree of arousal due to variations in blinking among an individual or between individuals. To execute the steps of: acquiring first biological information related to an ocular potential of a user from a processing device worn by the user; and calculating a degree of arousal of the user based on a distance between a projection axis parallel to an equal degree of arousal line and a point where the first biological information is plotted in a coordinate space where a height and width are the axes for an ocular potential peak.

Abstract: Brain activity of a user is detected, and a mental state of the user is determined. In one technique, life/work context is automatically presented to the user in a manner that modulates the mental state of the user. In another technique, an entertainment selection is presented to the user, and an entertainment selection list is automatically modified in response to the determined mental state of the user. In still another technique, the mental state that is determined is a negative emotional state, and life/work context is automatically presented to the user in a manner that promotes a cognitive state of the user in response to the determined emotional state of the user. In yet another technique, the wellness of the user is automatically tracked over a time period based on the determined mental state.

Abstract: Embodiments of a method and/or system for characterizing one or more female reproductive system-related conditions can include determining a microorganism dataset associated with a set of subjects; and/or performing a characterization process associated with the one or more female reproductive system-related conditions, based on the microorganism dataset, where performing the characterization process can additionally or alternatively include performing a female reproductive system-related characterization process for the one or more female reproductive system-related conditions, and/or determining one or more therapies.