Abstract: The compounds are benzoyl benzofurans and benzothiophenes having pharmacological activity, in particular, coronary vasodilator activity useful for the treatment of angina pectoris and intermediates for the preparation thereof.

Abstract: 4-AMINO-2,2,6,6-TETRAMETHYL PIPERIDINE IS PREPARED BY REACTING PHORONE WITH AMMONIA AND HYDROGEN IN THE PRESENCE OF A HYDROGENATION CATALYST. The reaction is generally carried out at a temperature in the range of from 80.degree. to 200.degree. C and under a pressure of from 80 to 250 atmospheres.

Abstract: 1-(3-Aryloxy-2-hydroxypropyl)-3- or 4-(1-oxoisoindolino)-piperidines, e.g. those of the formula ##STR1## 2-ALKANOIC ACID ESTERS AND ACID ADDITION SALTS THEREOF ARE ANTIHYPERTENSIVE AND ANTIARRHYTHMIC AGENTS.

Abstract: Novel 1-aryl and aralkyl 5-substituted biguanide compounds have been prepared. The compounds of this invention possess useful antiulcerogenic properties.

Abstract: A continuous process for the preparation of maleic anhydride from an aqueous solution of maleic acid formed in the production of maleic anhydride by the catalytic oxidation of aliphatic or aromatic hydrocarbons, with the continuous elimination of the impurities which accompany this maleic acid solution or which are subsequently formed in the course of the conversion of maleic acid into maleic anhydride.

Abstract: Tetrachloropyridine is prepared by heating pentachloropyridine in an aqueous medium under pressure, with agitation, in the presence of a particulate oxidizable metal, e.g., zinc and a hydrogen-producing acid, e.g., hydrogen chloride. The tetrachloropyridine is then conveniently extracted with an inert, water-immiscible solvent, e.g., a halogenated hydrocarbon.

Abstract: Compounds of the formula: ##SPC1##Are disclosed. In this structural formula X is ##SPC2##And Y is hydrogen, lower alkyl, hydroxy, lower alkoxy, chloro, bromo or aryl. Included within the scope of this invention are tautomers of the above compound. These compounds and their tautomers are indicated in the management of allergic manifestations such as bronchial asthma.

Abstract: Novel heterocyclic esters of benzopyranopyridines represented by the formula ##SPC1##Wherein R.sub.1 is hydrogen, lower alkyl, lower alkanoyl, cycloalkyl-lower alkyl, cycloalkyl-lower alkanoyl, lower alkenyl, lower alkynyl, halo-loweralkenyl, phenyl-lower alkyl, phenyl-lower alkenyl or phenyl-lower alkynyl; R.sub.2 is lower alkyl; R.sub.3 is an alkyl having one to twenty carbon atoms or a cycloalkyl-lower alkyl, Y is a straight or branched chain alkylene having one to eight carbon atoms, and R.sub.4 is a group of the formula ##EQU1## a is an integer from 1 to 4, b is an integer from 1 to 4 and X is CH.sub.2, O, S or N--R.sub.5 with R.sub.5 being hydrogen or lower alkyl, with the limitation that when X is O, S or N--R.sub.5, a and b each must be 2 and R.sub.6 is hydrogen or a lower alkyl group bonded to a carbon in the ring; and the acid addition salts thereof.

Abstract: The invention concerns novel indenopyridine derivatives of the formula: ##SPC1##Wherein m is 1, 2, 3 or 4, andR.sub.3 is an --O--R.sub.4 group,Wherein R.sub.4 is alkyl of 1 to 5 carbon atoms, phenyl or phenylalkyl, wherein the alkyl radical is of 1 to 4 carbon atoms, or an ##EQU1## group, WHEREIN EACH OFR.sub.5 and R.sub.6 is, independently, hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or phenyl-alkyl, wherein the alkyl radical is of 1 to 4 carbon atoms, orR.sub.5 and R.sub.6 together with the nitrogen atom form a saturated 5- or 6-membered heterocyclic ring, the heterocycle being selected from heterocycles containing 1 nitrogen atom, 1 nitrogen atom and 1 oxygen atom, and 1 nitrogen atom and a further nitrogen atom substituted by an alkyl radical of 1 to 4 carbon atoms,Useful as anti-aggressives and in the treatment of excitation conditions.

Abstract: Vindoline and vinblastine demethylated by submerged culture fermentation with S. albogriseolus.

Abstract: Novel benzimidazolinone derivatives and therapeutically acceptable acid addition salts thereof, said compounds being useful as long acting neuroleptic agents.

Abstract: Disclosed are 1-, 2-, or 3-cyano-N-alkyl-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds having pharmaceutical utility as tranquilizers; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when a tranquilizing effect is indicated.

Abstract: The invention provides vincaminic acid esters of formula ##SPC1##Wherein R.sub.1 is hydrogen or hydroxy, R.sub.2 is hydrogen or R.sub.1 and R.sub.2 form an additional bond between the two carbon atoms to which they are attached, and R.sub.3, R.sub.4 and R.sub.5 are hydrogen or methyl, and their salts. The esters are useful in treatment of cardiac-circulatory, cerebal-vascular or respiratory insufficiency.

Abstract: Prostaglandin F.sub.1.sub..alpha., prostaglandin F.sub.1.sub..beta., and analogs of those are produced from bicyclo[3.1.0]hexane intermediates.

Abstract: Aminoacyl derivatives of 2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c] [1,4]benzodiazepines in the form of their racemic mixtures, optical isomers and salts, their method of preparation and method of use are described. The compounds are useful in treating anxiety in warm-blooded animals.

Abstract: Compounds are provided having the structure ##SPC1##Wherein n is 1 or 2, n.sup.1 is 0, 1 or 2 and n.sup.2 is 0, 1, 2 or 3, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, R can be lower alkoxy, lower alkyl or cycloalkyl, R.sub.8 can be hydrogen, lower alkyl, cycloalkyl, hydroxy, dialkylaminoalkyl or R.sub.9 O(CH.sub.2)q--. X is a single bond or a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.

Abstract: Compounds are provided having the structure ##SPC1##Wherein n is 1, 2 or 3, m and m' are 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##EQU1## amido ##EQU2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##EQU3## These compounds are useful in the treatment of hypertension.

Abstract: Certain 3-substituted octahydropyridoindolobenzazepines and their addition salts with pharmaceutically acceptable acids produce a marked central nervous system depressant activity in warm-blooded animals. These compounds are stereoisomers of prior art 3-substituted octahydropyridoindolobenzazepines which have a central nervous system antidepressant activity.

Abstract: Novel 2,7-bis-basic derivatives of fluorene, 9-fluorenol and 9-fluorenone, their preparation and use for the prevention and inhibition of virus infections are disclosed.

Abstract: Hexahydro-.gamma.-carboline derivatives of the formula: ##SPC1##Wherein R.sub.1 is methyl or ethyl, and R.sub.2 is hydrogen, methyl or ethyl, with proviso that when R.sub.1 is ethyl, R.sub.2 is hydrogen, and their pharmaceutically acceptable acid addition salts, which exhibit excellent psychotropic effect, and a process for the preparation thereof.