Patents Examined by G. Thomas Todd
  • Benzospiran derivatives
    Patent number: 3932425
    Abstract: This invention relates to novel benzospiran derivatives embraced by the formula ##SPC1##Wherein the sum of A and B is at least the integer 2; A is selected from the group consisting of --(CH.sub.2).sub.n -- wherein n is 1 through 5 and --(C.sub.n H.sub.2n --.sub.2 XY)-- wherein X is selected from the group consisting of hydroxy, acetoxy, amino and acetamido and Y is hydrogen, and X when taken together with Y is selected from the group consisting of =O and =CR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen and lower alkyl of 1 through 3 carbon atoms; B is absent or --(CH.sub.2).sub.n -- wherein n is 1 through 3; R.sup.1 is selected from the group consisting of hydrogen and lower alkyl of 1 through 3 carbon atoms; R.sup.
    Type: Grant
    Filed: April 12, 1974
    Date of Patent: January 13, 1976
    Assignee: The Upjohn Company
    Inventor: Daniel Lednicer
  • Process for piperidine intermediates for quinine, quinidine and analogs thereof
    Patent number: 3931192
    Abstract: Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon.-carboxaldehyde, and a 4,5-crythro-5-ethyl(or vinyl)-quinuclidine-2.epsilon. -carboxylic acid and esters thereof. The end products are useful as antimalarial and antiarrhythmic agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic
  • 2,3-Dihydro-5-alkoxy-5-phenyl-5H-imidazo[2,1-a]isoindoles
    Patent number: 3931217
    Abstract: Novel 2[2-(1,3-diazacycloalk-2-enyl)]benzophenone compounds and novel 1,3-diazacycloalkenyl[2,1-a]isoindole compounds having useful analgesic and psychostimulant properties are prepared inter alia by condensation of o-benzoylbenzaldehydes with aliphatic diamines.
    Type: Grant
    Filed: May 6, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Metlesics, Leo Henryk Sternbach
  • Quinuclidine derivatives
    Patent number: 3931193
    Abstract: Quinine, quinidine and analogs thereof, are prepared by reacting a 4-quinolyllithium compound with a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde or the corresponding quinuclidine-2-carboxylic acid alkyl ester. Also described, inter alia, is the preparation of a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxaldehyde, and a 4,5-erythro-5-ethyl(or vinyl)-quinuclidine-2 .xi.-carboxylic acid and esters thereof. The end products are useful as anti-malarial and antiarrhythmic agents.
    Type: Grant
    Filed: May 2, 1974
    Date of Patent: January 6, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Guenter Grethe, Milan Radoje Uskokovic