Patents Examined by Gabrielle Bugaisky
  • Patent number: 6462175
    Abstract: The invention provides an isolated gene encoding Mch3, or functional fragment thereof. Also provided is an isolated nucleic acid sequence encoding Mch3 or functional fragment thereof. The gene or nucleic acid sequence can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch3 nucleotide sequence. An isolated Mch3 polypeptide or functional fragment thereof is also provided.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: October 8, 2002
    Assignees: Thomas Jefferson University, Idun Pharmaceuticals, Inc.
    Inventors: Emad S. Alnemri, Teresa Fernandes-Alnemri, Gerald Litwack, Robert Armstrong, Kevin Tomaselli
  • Patent number: 6462177
    Abstract: Disclosed are nucleic acids encoding novel proteins, designated kd312. Also disclosed are amino acid sequences for kd312 polypeptides, methods for preparing kd312 polypeptides, and other related aspects.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: October 8, 2002
    Assignee: Amgen Inc.
    Inventor: Kwang-Mu Yen
  • Patent number: 6455304
    Abstract: Disclosed are DNA sequences encoding hyaluronic acid synthase that are employed to construct recombinant cells useful in the production of hyaluronate synthase and hyaluronic acid (HA). In preferred aspects, chromosomal DNA encoding the HA synthase gene, hasA, was cloned from a Streptococcus pyogenes genomic library. These vectors were used to transform host cells such as E. coli and acapsular Streptococci to produce hyaluronic acid. Resultant transformants were screened to identify colonies which have incorporated HA synthase DNA in a form that is being actively transcribed into the corresponding HA synthase enzyme. These colonies were selected and employed in the production of hyaluronic acid.
    Type: Grant
    Filed: September 3, 1998
    Date of Patent: September 24, 2002
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Paul L. DeAngelis, John Papaconstantinou
  • Patent number: 6455296
    Abstract: The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: September 24, 2002
    Assignee: Thomas Jefferson University
    Inventors: Emad S. Alnemri, Teresa Fernandes-Alnemri, Gerald Litwack
  • Patent number: 6448224
    Abstract: The present invention discloses novel antibiotic peptides, including naturally occurring peptides. The present invention also includes the nucleic acid sequence encoding such peptides and the corresponding amino acid sequences. Methods of identifying, making, and using the antibiotic peptides are also disclosed.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: September 10, 2002
    Assignee: St. Jude Children's Research Hospital
    Inventors: Rodger Novak, Elaine I. Tuomanen
  • Patent number: 6448226
    Abstract: The present invention relates to transformed plants and plant cells comprising DNA molecules encoding Bacillus thuringiensis proteins with insecticidal activity. The invention relates more particularly to transformed plants and plant cells comprising DNA molecules encoding the protease resistant toxins BTS02618Aa or BTS02618Ab, as well as to methods of rendering plants or plant cells resistant to insects using these DNA molecules.
    Type: Grant
    Filed: December 23, 1999
    Date of Patent: September 10, 2002
    Assignee: Aventis CropScience N.V.
    Inventors: Bart Lambert, Stefan Jansens, Katrien Van Audenhove, Marnix Peferoen, Jeroen Van Rie, Roel Van Aarssen
  • Patent number: 6428993
    Abstract: The present invention relates to transglutaminases and transglutaminase preparations obtained from lower fungi belonging to the class Oomycetes. Unprecedented high-level expression is achievable by growing these coenocytium forming organisms, especially the strains Pythium sp., Pythium irregulare, Pythium dissotocum, Pythium periilum (or P. periplocum), Pythium torulosum, Pythium ultimum, Pythium aphanidermatum, Phytophthora cactorum, Phytophthora palmivora, Phytophthora porri, Phytophthora infestans, Phytoph-thora megasperma, Phytophthora cinnamomi and Phytophthora cryptogea. Arecombinant transglutaminase has been cloned and expressed, the enzyme and enzyme preparations being useful for cross-linking proteins, e.g. in flour, baked products, meat products, fish products, cosmetics, cheese, milk products, gelled food products and leather finishing, or as a glutaminase, e.g. in bread and other baked glutein-containing food products.
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: August 6, 2002
    Assignee: Novozymes A/S
    Inventors: Lisbeth Bech, Grethe Rasmussen, Torben Halkier, Mariko Okada, Lene Nonboe Andersen, Markus Sakari Kauppinen, Thomas Sandal
  • Patent number: 6395510
    Abstract: The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: May 28, 2002
    Assignees: ARCH Development Corporation, Board of Regents of The University of Michigan
    Inventors: Craig B. Thompson, Lawrence H. Boise, Gabriel Nuñez
  • Patent number: 6379946
    Abstract: Proteins from the genus Xenorhabdus are toxic to insects upon oral exposure. These protein toxins can be applied to insect larvae food and plants for insect control.
    Type: Grant
    Filed: February 28, 2000
    Date of Patent: April 30, 2002
    Assignee: Wisconsin Alumn Research Foundation
    Inventors: Jerald C. Ensign, David J. Bowen, Jennifer L. Tenor, James K. Petell, Gregory L. Orr, Scott B. Bintrim, Todd A. Ciche, James A. Strickland, Raymond O. Fatig, Richard H. Ffrench-Constant