Patents Examined by Garnette D. Drarer
  • Non-covalent antibody-anthracycline immunocomplexes
    Patent number: 5004606
    Abstract: A composition comprising a non-covalent immunocomplex of an anthracycline agent and an antibody selected to bind a target antigen and enhance the cytotoxicity of the anthracycline agent is disclosed. In accordance with the invention, the efficacy of an anthracycline as an anti-tumor agent for use in in vivo therapy is enhanced by administering to a patient a non-covalent immunocomplex provided herein.
    Type: Grant
    Filed: September 24, 1986
    Date of Patent: April 2, 1991
    Assignee: Hybritech Incorporated
    Inventors: James M. Frincke, Richard M. Bartholomew, Robert O. Dillman