Patents Examined by Gary E. Hollinden
  • Patent number: 10600178
    Abstract: The present disclosure relates to methods for determining a wavefront position of a liquid on a surface of an assay test strip placing a liquid on the surface of the test strip; and acquiring one or more signals from the surface of the test strip at one or more times, comparing the one or more acquired signals to a threshold, wherein the wavefront position is a position on the surface of the test strip where a signal is greater than or less than a threshold (e.g., fixed or dynamic threshold). Such methods may be used to determine the wavefront velocity of a liquid on a surface of an assay test strip and the transit time of a liquid sample to traverse the one or more positions on the surface of the assay test strip.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 24, 2020
    Assignee: Alverix, Inc.
    Inventor: Scott Dylewski
  • Patent number: 10451616
    Abstract: The present invention relates to a method for quantitating an analyte having a wide range concentration in a single assay without having to dilute the sample and repeating the assay. The key feature of the invention is having two cycles of events including sample binding to probe, binding reactions, and detection. After the first cycle of binding and detecting, the probe is dipped into the same sample vessel to bind additional analyte in the sample vessel at a condition that is more favorable to binding than the condition in the first cycle.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Access Medical Systems, LTD.
    Inventor: Robert F. Zuk
  • Patent number: 10335783
    Abstract: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure that the rim applies on the matrix prevents leakage of liquids out of the capillary flow matrix at the reservoir/matrix interface, allowing accurate sequential draining of liquid from the reservoirs.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: July 2, 2019
    Inventors: Sara Alajem, Avraham Reinhartz
  • Patent number: 10299714
    Abstract: Disclosed are devices for collecting and stabilizing blood that contain a blood stabilization agent which includes variegin or an analog thereof, a polysulfated disaccharide, or a combination thereof, each in an amount effective to stabilize blood. Methods of making and using the devices, and kits containing the devices, are also provided.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: May 28, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Craig A. Gelfand, Daniel Marchiarullo, Keith Moskowitz
  • Patent number: 10215753
    Abstract: Disclosed is a method of preparing a biosensor that involves providing a substrate including a surface having a topographical pattern formed at one or more sites on or in the surface, coating the substrate with a solution including hydrogel particles, wherein the hydrogel particles self-assemble on the surface to mask the surface except at the one or more sites, and binding one or more capture molecules to the one or more sites to form the biosensor. Systems that include the biosensor, as well as methods of using the biosensor, are also disclosed.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: February 26, 2019
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Mark A. Lifson, Dhruba Jyoti Basu Roy
  • Patent number: 10191028
    Abstract: A new type of matrices for Matrix Assisted Laser Desorption and Ionization technique based on derivatized carbon clusters, which will be suitable for the analysis of peptides, proteins and other biomolecules by mass spectrometry which has several advantages over conventional matrices, such as optical sensitivity in a broad spectrum, low interference in the wide mass range and high analyte ionization efficiency.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: January 29, 2019
    Assignee: Ionwerks
    Inventors: John Albert Schultz, Michael V. Ugarov
  • Patent number: 10156579
    Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: December 18, 2018
    Assignee: Theranos IP Company, LLC
    Inventors: Ian Gibbons, Shaunak Roy, Edmond Ku
  • Patent number: 10151694
    Abstract: A method of evaluating an interaction parameter for the interaction between a plurality of analytes and a ligand using a biosensor, which comprises the steps of: A: providing a sensor surface having the ligand immobilized thereto, B: contacting the sensor surface with the plurality of analytes, C: registering a sensor response curve for each one of the plurality of analytes, D: extracting interaction parameters from each sensor response curve, E: evaluating each sensor response curve according to one or more binding behavior criteria, F: displaying the interaction parameters in a diagram, wherein interaction parameters relating to response curves meeting a binding behavior criteria are graphically distinguishable from interaction parameters relating to response curves meeting another or no binding behavior criteria.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: December 11, 2018
    Inventor: Olof Karlsson
  • Patent number: 10119968
    Abstract: A test unit collects and analyzes biological specimens on-site. It has one or more openings that allow reagent capsules to be inserted and guided into a testing chamber. Reagent capsules are pre-loaded with chemicals for screening and are configured as blister packs. A button mechanism allows projection(s) to open the blister packs to allow chemicals within the capsules to mix inside the testing chamber. A medical swab is affixed to a pop top dispenser cap and can be pressed to allow the swab to be inserted into the mixed chemicals. A visible test strip mount attached to the testing chamber has a lever to manipulate a test strip in and out of the testing chamber. This test strip may be slid through a uni-directional seal on a capsule and into a chemical for testing. The test strip will test for the presence of an infectious disease.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: November 6, 2018
    Inventor: Bliss Hanlon Lansing
  • Patent number: 10082501
    Abstract: Nanotube based lateral flow test device described herein is a lateral flow based diagnostic device, which uses arrays of fragments of single wall carbon nanotubes as sensor to detect the biomarkers at ultralow concentration (below picogram per milliliter). The device is consisted of the following components: (1). an lateral flow strip which typically is consisted of a backing film laminated with conjugate/sample pads, nitrocellulose membrane, wicking pad, (2). the arrays of single wall carbon nanotube conjugate with antibody which is immobilized on the membrane of the lateral flow device as the test line, (3). pairs of micro-electrode are installed on top part of the cassette, (4). a cassette which holds the lateral flow strip. The device can be used in clinical environments for biomarker detection.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: September 25, 2018
    Assignee: BioMedomics, Inc.
    Inventors: Xue-feng Wang, Qingqi Chen
  • Patent number: 10048207
    Abstract: Provided are compositions, kits, and methods for detecting a vesicle comprising a membrane permeable marker that is converted into a detectable marker inside the vesicle.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: August 14, 2018
    Inventors: Hyun-ju Kang, Ye-ryoung Yong, Myo-yong Lee
  • Patent number: 10041952
    Abstract: Provided is a composition for detecting a protein, containing a tyrosine oxide-coupled biomaterial. Various diseases may be easily and rapidly diagnosed by easily detecting the composition containing a tyrosine oxide-coupled biomaterial according to the present invention, by identifying a color of the protein bound with a tyrosine oxide-coupled biomaterial prepared by binding tyrosine oxide, which is a natural pigment present in a living body, with the biomaterial. Accordingly, the composition of the present invention may be used to easily and rapidly diagnose various diseases in real time in an operating room, and may usefully replace conventional histological analysis without a secondary antibody reaction and a final operation of color expression.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: August 7, 2018
    Inventors: Kook Jin Lim, Jin Ik Lim, Bum Joon Kim, Kyung Hwa Yoo, Soo Jung Park
  • Patent number: 10031100
    Abstract: Lateral flow assay devices for determining the concentration of a biomolecular analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow assay devices.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: July 24, 2018
    Assignee: Robert Bosch GmbH
    Inventors: Christopher Johnson, Sam Kavusi, Habib Ahmad, Christoph Lang
  • Patent number: 10024795
    Abstract: Provided is a method of monitoring a vesicle in a sample, including contacting a vesicle in a sample with a membrane permeable marker that is converted into a detectable marker in the vesicle, measuring a signal of the detectable marker, and monitoring the vesicle based on the measured signal.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: July 17, 2018
    Inventors: Hyun-ju Kang, Ye-ryoung Yong, Myo-yong Lee
  • Patent number: 10001482
    Abstract: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: June 19, 2018
    Assignee: Quidel Corporation
    Inventors: Franz Aberl, Marcus Scheibenzuber, Robert P. Sambursky, Robert W. VanDine, Jose S. Sambursky
  • Patent number: 9995688
    Abstract: This invention relates to the use of thermodynamically incompatible surfaces in agglutination assays for the express purpose of using the sample as a key component of the detection instrument. Specifically, the invention relates to formation of a lense and a virtual container for rapid mixing via thermal energy by a sample liquid disposed on a superhydrophobic surfaces, and a subsequent specific analyte or overall protein concentration assay using particles agglutination for use in the industrial, environmental, and clinical laboratory test fields.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: June 12, 2018
    Assignee: Arizona Board of Regents
    Inventors: Antonio Garcia, John Schneider
  • Patent number: 9982292
    Abstract: Methods and systems for detecting chemical and biological agents using oligonucleotide aptamers. A sensor includes a detection aptamer that has a binding domain for the chemical or biological agent, and is bound to fibers of a textile such as a patch or article of clothing. The detection aptamer can be stabilized and enhanced through a stabilization agent such as trehalose or through binding to a nanoparticle which is then bound to the fiber. Binding of the chemical and biological agent of interest to the detection aptamer can be reported to the user or wearer of the textile in a variety of ways, including visually and electrically.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: May 29, 2018
    Assignee: SRC, INC.
    Inventor: Adam J. Lowe
  • Patent number: 9976959
    Abstract: A biological substance detection method for detecting a biological substance specifically in a pathological specimen, comprising a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: May 22, 2018
    Inventors: Kensaku Takanashi, Hideki Goda, Hisatake Okada, Yasushi Nakano, Kohsuke Gonda, Motohiro Takeda, Noriaki Ohuchi
  • Patent number: 9952207
    Abstract: When an immunochromatography reagent composition containing a nonionic surfactant, an N,N-bis(2-hydroxyethyl)glycine buffer, and casein is used as a specimen treatment solution or developing solution in detecting a detection object in a specimen according to an immunochromatographic method, an immunochromatography reagent composition which suppresses a non-specific reaction; does not cause aggregation of antibody-immobilized colloidal gold; and has a high developing rate, in comparison with conventional technology which detects a detection object by using an immunochromatographic device; and a high-performance and highly-sensitivity immunochromatographic method and a detection kit capable of rapid, simple and easy virus detection, which use the immunochromatography reagent composition are provided.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: April 24, 2018
    Inventors: Hisahiko Iwamoto, Yuhiro Sakakibara, Satoru Nakajima
  • Patent number: 9949724
    Abstract: A specimen collection cup has a container. The container has a wall and a floor and is configured for receiving and retaining a specimen. A section of the wall is transparent. Further, the container has a tab coupled to an inside surface of the wall that creates a slot for receiving a test card having a reagent pad affixed thereto. The tab is coupled to the inside surface of the wall such that when the test card is inserted in the slot indicia on the test card is aligned with the transparent section.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: April 24, 2018
    Assignee: Instant Tech Subsidiary Acquisition Inc.
    Inventor: Larry Hartselle