Patents Examined by Gary Geist
  • Patent number: 7018612
    Abstract: The invention relates to a method of preparing a solution of a radioactive rhenium complex, by reacting at elevated temperature a radioactive perrhenate in a substantially aqueous solution with a ligand in the presence of a reductant and optionally an antioxidant under substantially anaerobic conditions, wherein said reaction is carried out at a pH from approx. 1.5 to approx. 5 and by heating the reaction components for at least 10 min. at a temperature of at least 100° C. The invention further relates to a kit for performing said method.
    Type: Grant
    Filed: July 2, 1991
    Date of Patent: March 28, 2006
    Assignee: Mallinckrodt Inc.
    Inventors: Helena Panek-Finda, David W. Pipes
  • Patent number: 6762315
    Abstract: The invention relates to a method for producing [1,1′:4′,1″]-terphenyl compounds of the formula which comprises reacting a metal aryl of the formula with a boric ester at −80 to 40° C. in the presence of an inert solvent, converting the reaction product by hydrolysis into a boronic acid of the formula reacting the boronic acid, a boronic anhydride obtainable from boronic acid by elimination of water, or a mixture of boronic acid and boronic anhydride, with an alcohol, and reacting the boronic ester formed thereby with a biphenyl compound of the formula at 40 to 180° C. in the presence of a catalyst, of an acid-binding agent and of a polar solvent.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: July 13, 2004
    Assignee: Clariant GmbH
    Inventors: Stefan Scherer, Steffen Haber
  • Patent number: 6632958
    Abstract: An alkene (1) is added to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reagent to form an adduct, said adduct is reacted with e.g.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: October 14, 2003
    Assignee: Mitsubishi Pharma Corporation
    Inventors: Masahiro Urushihara, Yoshitomi Morizawa
  • Patent number: 6602861
    Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula: or pharmaceutically acceptable salts thereof wherein one of R1 and R2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources; R3 is hydrogen or lower alkyl and R4 is hydrogen, hydrocarbyl containing from 1-18 carbon atoms in a principal chain and up to a total of 23 carbon atoms, said principal chain may contain 1-5 double bonds or 1-2 triple bonds; phenyl which may be unsubstituted or substituted with lower alkyl; naphthyl which may be unsubstituted or substituted with low
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: August 5, 2003
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Charles Pidgeon, Robert J. Markovich
  • Patent number: 6596670
    Abstract: The use is disclosed of at least substantially water-insoluble ethers which are fluid and/or at least plastically deformable at working temperature and have flash points of at least 80° C., of mono- and/or polyfunctional alcohols of natural and/or synthetic origin or corresponding solutions of such ethers in ecologically acceptable water-insoluble oils as the dispersed oil phase of water-based O/W-emulsion drilling fluids which are suitable for the environmentally acceptable development of geological formations and which contain, if desired, insoluble, finely particulate weighting agents for the formation of water-based O/W-emulsion drilling muds and/or further additives, such as emulsifiers, fluid-loss additives, wetting agents, alkali reserves and/or auxiliary substances for the inhibition of drilled rock of high water-sensitivity.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: July 22, 2003
    Assignees: Cognis Deutschland GmbH & Co. KG, Baroid Limited
    Inventors: Heinz Mueller, Claus-Peter Herold, Stephan von Tapavicza, Gerhard Stoll, Rainer Jeschke, Johann Friedrich Fues
  • Patent number: 6552183
    Abstract: Novel monocyclic L-Nucleoside compounds have the general formula Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel compounds show immunomodulatory activity, and are expected to be useful in modulating the cytokine pattern, including modulation of Th1 and Th2 response.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: April 22, 2003
    Assignee: ICN Pharmaceuticals, Inc.
    Inventors: Kandasamy Ramasamy, Robert Tam, Devron Averett
  • Patent number: 6531626
    Abstract: There is disclosed a method for producing cyclopropanecarboxylates of the formula (3): by transesterification in the presence of a lanthanoid metal alkoxide
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: March 11, 2003
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshiaki Oda, Makoto Yako
  • Patent number: 6528640
    Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, incorporated
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
  • Patent number: 6506788
    Abstract: The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: January 14, 2003
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Patent number: 6495579
    Abstract: Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: December 17, 2002
    Assignee: Angiotech Pharmaceuticals, Inc.
    Inventor: William L. Hunter
  • Patent number: 6492349
    Abstract: A therapeutic composition for the protection, treatment and repair of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes glucosamine and preferably chondroitin sulfate or fragments thereof. The composition optionally includes manganese ascorbate which catalyzes the production of collagen and proteoglycans from the glucosamine and chondroitin sulfate.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: December 10, 2002
    Assignee: Nutramax Laboratories, Inc.
    Inventor: Robert W. Henderson
  • Patent number: 6492420
    Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: December 10, 2002
    Assignee: PhotoCure AS
    Inventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth
  • Patent number: 6475991
    Abstract: The present invention embraces methods and compositions which employ antimicrobial compositions which are &agr;-alkylglucosides and esters thereof.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: November 5, 2002
    Assignee: Ulice
    Inventors: Emmanuel Boures, Arnaud Messager
  • Patent number: 6472555
    Abstract: The present invention relates to a process for the preparation of esters from alcohols using acetic acid as acetylating agent and clays as catalysts, which comprises the preparation of esters in a single step from the reaction of aliphatic, acyclic, cyclic, heterocyclic, &agr;,&bgr;-unsaturated and aromatic alcohols with carbon atoms in the range of C1 to C10 with acetic acid in a molar ratio of 1:3 to 11 using reusable natural montmorillonite/metal ion-exchanged clay catalysts in the solvent medium of aliphatic, aromatic, or chlorinated hydrocarbons at 30-140° C. for a period in the range of 0.02 to 3.0 hrs, and recovering the corresponding esters by simple work-up procedure.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: October 29, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Boyapati Manoranjan Choudary, Veldurthy Bhaskar, Mannepalli Lakshmi Kantam, Kottapalli Koteswara Rao, Kondapuram Vijaya Raghavan
  • Patent number: 6465690
    Abstract: A process for preparing polyamino monosuccinic acids, salts or chelates thereof by (a) reacting a maleic or fumaric acid ester or mixtures thereof with a polyamino compound in a primary alcohol as a solvent, (b) hydrolyzing the product obtained in step (a), and (c) separating the primary alcohol. The use of a primary alcohol as the solvent results in a markedly purer polyamino monosuccinic acid product and simpler reaction conditions than when the solvent is a secondary or tertiary alcohol.
    Type: Grant
    Filed: February 23, 2000
    Date of Patent: October 15, 2002
    Assignee: The Dow Chemical Company
    Inventors: Alan D. Strickland, David A. Wilson, Brian D. Burkholder, Druce K. Crump
  • Patent number: 6465679
    Abstract: This invention involves a carbamate functional polymer or oligomer made by reacting a cyclic carbonate with ammonia or a primary amine, then reacting the resulting hydroxycarbamate with a polyfunctional material containing groups reactive with hydroxyl groups to form a polyfunctional carbamate. The polymer formed is mixed with an aminoplast, coated on a substrate and cured to form a crosslinked coating.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: October 15, 2002
    Assignee: Eastman Chemical Company
    Inventors: Dean C. Webster, Allen L. Crain
  • Patent number: 6462232
    Abstract: Provided is a process for producing acrylic acid stably at a high yield over a long period of time by subjecting acrolein or acrolein-containing gas to catalytic vapor phase oxidation. The above process is characterized by controlling the reaction so that the following equations (1) and (2) are satisfied: 1° C.≦T0−T1≦15° C.  (1) T1<T2  (2) wherein T0 represents a temperature of acrolein or the acrolein-containing gas in an inlet of a catalyst layer; T1 represents a temperature in an inlet part of the catalyst layer; and T2 represents a temperature in an outlet part of the catalyst layer.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: October 8, 2002
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Daisuke Nakamura, Hideyuki Hironaka, Michio Tanimoto
  • Patent number: 6458993
    Abstract: The present invention relates to novel aromatic cyanate ester compounds containing at least two rings linked by a group containing an unsaturated group. The present invention further relates to compositions and prepolymers of said novel aromatic cyanate ester compounds. The present invention further relates to a process for preparing said compounds and cured articles resulting from curable mixtures thereof.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: October 1, 2002
    Assignee: Vantico Inc.
    Inventors: Bor-Sheng Lin, Michael James Amone
  • Patent number: 6458991
    Abstract: Compounds having alcoholic hydroxyl groups are esterified with acrylic or methacrylic acid in the presence of copper(II) salts or mixtures thereof as polymerization inhibitors and in the presence of a hydrocarbon as a water-entraining agent with removal of the water of reaction at from 90 to 150° C. After the esterification, the copper salt is precipitated as copper sulfide and is separated off from the ester. The light-color (meth)acrylates resulting in the high yields are particularly suitable for coatings containing colored pigment on substrates such as wood, paper, mineral building materials, plastics or metal.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: October 1, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfgang Paulus, Wolfgang Reich, Erich Beck, Thomas Jaworek, Rainer Königer
  • Patent number: 6458996
    Abstract: In a process for the production of acetic acid by carbonylation of methanol and/or a reactive derivative in the presence of a Group VIII noble metal carbonylation catalyst, methyl iodide co-catalyst at a concentration of at least 2 wt %, optionally at least one promoter at least a finite concentration of water, methyl acetate at a concentration of at least 8% w/w and acetic acid product, the separability of an upper (aqueous) layer and a lower (organic) layer in the decanter of the light ends column is achieved by maintaining the concentration of acetic acid in the condensed overhead vapor fraction passed to the decanter at or below 8 wt %.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: October 1, 2002
    Assignee: BP Chemicals Limited
    Inventor: Michael James Muskett