Patents Examined by Gary Geist
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Patent number: 7018612Abstract: The invention relates to a method of preparing a solution of a radioactive rhenium complex, by reacting at elevated temperature a radioactive perrhenate in a substantially aqueous solution with a ligand in the presence of a reductant and optionally an antioxidant under substantially anaerobic conditions, wherein said reaction is carried out at a pH from approx. 1.5 to approx. 5 and by heating the reaction components for at least 10 min. at a temperature of at least 100° C. The invention further relates to a kit for performing said method.Type: GrantFiled: July 2, 1991Date of Patent: March 28, 2006Assignee: Mallinckrodt Inc.Inventors: Helena Panek-Finda, David W. Pipes
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Patent number: 6762315Abstract: The invention relates to a method for producing [1,1′:4′,1″]-terphenyl compounds of the formula which comprises reacting a metal aryl of the formula with a boric ester at −80 to 40° C. in the presence of an inert solvent, converting the reaction product by hydrolysis into a boronic acid of the formula reacting the boronic acid, a boronic anhydride obtainable from boronic acid by elimination of water, or a mixture of boronic acid and boronic anhydride, with an alcohol, and reacting the boronic ester formed thereby with a biphenyl compound of the formula at 40 to 180° C. in the presence of a catalyst, of an acid-binding agent and of a polar solvent.Type: GrantFiled: August 24, 2001Date of Patent: July 13, 2004Assignee: Clariant GmbHInventors: Stefan Scherer, Steffen Haber
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Patent number: 6632958Abstract: An alkene (1) is added to cyclopentenone (2) under the action of an alkyl lithium and an organic copper reagent to form an adduct, said adduct is reacted with e.g.Type: GrantFiled: December 4, 2000Date of Patent: October 14, 2003Assignee: Mitsubishi Pharma CorporationInventors: Masahiro Urushihara, Yoshitomi Morizawa
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Patent number: 6602861Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula: or pharmaceutically acceptable salts thereof wherein one of R1 and R2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources; R3 is hydrogen or lower alkyl and R4 is hydrogen, hydrocarbyl containing from 1-18 carbon atoms in a principal chain and up to a total of 23 carbon atoms, said principal chain may contain 1-5 double bonds or 1-2 triple bonds; phenyl which may be unsubstituted or substituted with lower alkyl; naphthyl which may be unsubstituted or substituted with lowType: GrantFiled: April 16, 1992Date of Patent: August 5, 2003Assignee: Research Corporation Technologies, Inc.Inventors: Charles Pidgeon, Robert J. Markovich
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Patent number: 6596670Abstract: The use is disclosed of at least substantially water-insoluble ethers which are fluid and/or at least plastically deformable at working temperature and have flash points of at least 80° C., of mono- and/or polyfunctional alcohols of natural and/or synthetic origin or corresponding solutions of such ethers in ecologically acceptable water-insoluble oils as the dispersed oil phase of water-based O/W-emulsion drilling fluids which are suitable for the environmentally acceptable development of geological formations and which contain, if desired, insoluble, finely particulate weighting agents for the formation of water-based O/W-emulsion drilling muds and/or further additives, such as emulsifiers, fluid-loss additives, wetting agents, alkali reserves and/or auxiliary substances for the inhibition of drilled rock of high water-sensitivity.Type: GrantFiled: March 3, 1993Date of Patent: July 22, 2003Assignees: Cognis Deutschland GmbH & Co. KG, Baroid LimitedInventors: Heinz Mueller, Claus-Peter Herold, Stephan von Tapavicza, Gerhard Stoll, Rainer Jeschke, Johann Friedrich Fues
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Patent number: 6552183Abstract: Novel monocyclic L-Nucleoside compounds have the general formula Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in terms of mechanism, embodiments of the novel compounds show immunomodulatory activity, and are expected to be useful in modulating the cytokine pattern, including modulation of Th1 and Th2 response.Type: GrantFiled: August 7, 2000Date of Patent: April 22, 2003Assignee: ICN Pharmaceuticals, Inc.Inventors: Kandasamy Ramasamy, Robert Tam, Devron Averett
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Patent number: 6531626Abstract: There is disclosed a method for producing cyclopropanecarboxylates of the formula (3): by transesterification in the presence of a lanthanoid metal alkoxideType: GrantFiled: October 7, 1999Date of Patent: March 11, 2003Assignee: Sumitomo Chemical Company, LimitedInventors: Yoshiaki Oda, Makoto Yako
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Patent number: 6528640Abstract: Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.Type: GrantFiled: December 29, 1999Date of Patent: March 4, 2003Assignee: Ribozyme Pharmaceuticals, incorporatedInventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
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Patent number: 6506788Abstract: The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance.Type: GrantFiled: August 14, 1998Date of Patent: January 14, 2003Assignee: GPI Nil Holdings, Inc.Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
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Patent number: 6495579Abstract: Methods and compositions for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis are provided, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or derivative thereof.Type: GrantFiled: June 1, 1998Date of Patent: December 17, 2002Assignee: Angiotech Pharmaceuticals, Inc.Inventor: William L. Hunter
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Patent number: 6492349Abstract: A therapeutic composition for the protection, treatment and repair of connective tissue in mammals and a method for the treatment of connective tissue in mammals by the administration of the composition. The composition includes glucosamine and preferably chondroitin sulfate or fragments thereof. The composition optionally includes manganese ascorbate which catalyzes the production of collagen and proteoglycans from the glucosamine and chondroitin sulfate.Type: GrantFiled: December 23, 1996Date of Patent: December 10, 2002Assignee: Nutramax Laboratories, Inc.Inventor: Robert W. Henderson
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Patent number: 6492420Abstract: The present invention relates to compounds being esters of 5-aminolevulinic acids or pharmaceutically acceptable salts thereof, including compounds of formula (I) R22N—CH2COCH2—CH2CO—OR1 (wherein R1 may represent alkyl optionally substituted by hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, amino, aryl, oxo or fluoro groups and optionally interrupted by oxygen, nitrogen, sulphur or phosphorus atoms; and R2 represents a hydrogen atom or a group R1, and both R2 groups may be the identical or different), and their use in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body, and products and kits for performing the invention.Type: GrantFiled: December 21, 1999Date of Patent: December 10, 2002Assignee: PhotoCure ASInventors: Karl E. Gierskcky, Johan Moan, Qian Peng, Harald Steen, Trond Warloe, Alf Bjorseth
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Patent number: 6475991Abstract: The present invention embraces methods and compositions which employ antimicrobial compositions which are &agr;-alkylglucosides and esters thereof.Type: GrantFiled: November 23, 1998Date of Patent: November 5, 2002Assignee: UliceInventors: Emmanuel Boures, Arnaud Messager
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Patent number: 6472555Abstract: The present invention relates to a process for the preparation of esters from alcohols using acetic acid as acetylating agent and clays as catalysts, which comprises the preparation of esters in a single step from the reaction of aliphatic, acyclic, cyclic, heterocyclic, &agr;,&bgr;-unsaturated and aromatic alcohols with carbon atoms in the range of C1 to C10 with acetic acid in a molar ratio of 1:3 to 11 using reusable natural montmorillonite/metal ion-exchanged clay catalysts in the solvent medium of aliphatic, aromatic, or chlorinated hydrocarbons at 30-140° C. for a period in the range of 0.02 to 3.0 hrs, and recovering the corresponding esters by simple work-up procedure.Type: GrantFiled: February 12, 1999Date of Patent: October 29, 2002Assignee: Council of Scientific and Industrial ResearchInventors: Boyapati Manoranjan Choudary, Veldurthy Bhaskar, Mannepalli Lakshmi Kantam, Kottapalli Koteswara Rao, Kondapuram Vijaya Raghavan
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Patent number: 6465690Abstract: A process for preparing polyamino monosuccinic acids, salts or chelates thereof by (a) reacting a maleic or fumaric acid ester or mixtures thereof with a polyamino compound in a primary alcohol as a solvent, (b) hydrolyzing the product obtained in step (a), and (c) separating the primary alcohol. The use of a primary alcohol as the solvent results in a markedly purer polyamino monosuccinic acid product and simpler reaction conditions than when the solvent is a secondary or tertiary alcohol.Type: GrantFiled: February 23, 2000Date of Patent: October 15, 2002Assignee: The Dow Chemical CompanyInventors: Alan D. Strickland, David A. Wilson, Brian D. Burkholder, Druce K. Crump
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Patent number: 6465679Abstract: This invention involves a carbamate functional polymer or oligomer made by reacting a cyclic carbonate with ammonia or a primary amine, then reacting the resulting hydroxycarbamate with a polyfunctional material containing groups reactive with hydroxyl groups to form a polyfunctional carbamate. The polymer formed is mixed with an aminoplast, coated on a substrate and cured to form a crosslinked coating.Type: GrantFiled: December 22, 2000Date of Patent: October 15, 2002Assignee: Eastman Chemical CompanyInventors: Dean C. Webster, Allen L. Crain
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Patent number: 6462232Abstract: Provided is a process for producing acrylic acid stably at a high yield over a long period of time by subjecting acrolein or acrolein-containing gas to catalytic vapor phase oxidation. The above process is characterized by controlling the reaction so that the following equations (1) and (2) are satisfied: 1° C.≦T0−T1≦15° C. (1) T1<T2 (2) wherein T0 represents a temperature of acrolein or the acrolein-containing gas in an inlet of a catalyst layer; T1 represents a temperature in an inlet part of the catalyst layer; and T2 represents a temperature in an outlet part of the catalyst layer.Type: GrantFiled: August 3, 1999Date of Patent: October 8, 2002Assignee: Nippon Shokubai Co., Ltd.Inventors: Daisuke Nakamura, Hideyuki Hironaka, Michio Tanimoto
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Patent number: 6458993Abstract: The present invention relates to novel aromatic cyanate ester compounds containing at least two rings linked by a group containing an unsaturated group. The present invention further relates to compositions and prepolymers of said novel aromatic cyanate ester compounds. The present invention further relates to a process for preparing said compounds and cured articles resulting from curable mixtures thereof.Type: GrantFiled: January 31, 2001Date of Patent: October 1, 2002Assignee: Vantico Inc.Inventors: Bor-Sheng Lin, Michael James Amone
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Patent number: 6458991Abstract: Compounds having alcoholic hydroxyl groups are esterified with acrylic or methacrylic acid in the presence of copper(II) salts or mixtures thereof as polymerization inhibitors and in the presence of a hydrocarbon as a water-entraining agent with removal of the water of reaction at from 90 to 150° C. After the esterification, the copper salt is precipitated as copper sulfide and is separated off from the ester. The light-color (meth)acrylates resulting in the high yields are particularly suitable for coatings containing colored pigment on substrates such as wood, paper, mineral building materials, plastics or metal.Type: GrantFiled: June 13, 2000Date of Patent: October 1, 2002Assignee: BASF AktiengesellschaftInventors: Wolfgang Paulus, Wolfgang Reich, Erich Beck, Thomas Jaworek, Rainer Königer
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Patent number: 6458987Abstract: The invention concerns novel chemical compounds, namely citronellyl lactate and dihydrocitronellyl lactate and their optically active forms. The invention also concerns the method for obtaining them. The invention further concerns their use in the field of perfumes.Type: GrantFiled: July 6, 2000Date of Patent: October 1, 2002Assignee: Rhodia ChimieInventor: Isabelle Storet