Abstract: It is provided an intraocular lens insertion system that achieves a preferable insertion of an intraocular lens without using viscoelastic material in an eyeball.

Abstract: A surgical clip applier includes a handle assembly and an elongated assembly configured to releasably engage the handle assembly. The handle assembly includes a trigger and a drive bar wherein pivoting of the trigger through a full actuation stroke translates the drive bar through a full drive distance. The drive bar has a magnetic distal end portion. The elongated assembly includes an inner drive assembly including a magnetic proximal end portion. Upon engagement of the elongated assembly with the handle assembly, the magnetic proximal end portion of the inner drive assembly is configured to attract the magnetic distal end portion of the drive bar to move the drive bar and pivot the trigger such that the trigger is pivotable through a reduced actuation stroke to translate the drive bar through a reduced drive distance.

Abstract: A device for manipulating an implant includes a handle coupled to a guide extending from the handle to a distal end. The device includes an engagement mechanism disposed at the distal end of the guide and configured to engage an implant. The device includes a first actuator disposed on the handle and coupled to the engagement mechanism. The first actuator causes the engagement mechanism to engage the implant. The device includes an air chamber disposed in an interior chamber of the handle and configured to hold air. The device includes a lumen coupled to the air chamber and extending along the guide to the distal end. The lumen includes an air channel extending through the lumen. The device includes a second actuator disposed on the handle. The second actuator causes the air chamber to deliver the air, via the air channel, to the distal end.

Abstract: Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Abstract: This disclosure concerns systems and methods for removal of material from the body of a patient, and particularly for percutaneous nephrolithotomy. Systems according to the various embodiments of the disclosure include one or more of nested first and second components, for instance a scope nested within a suction or irrigation catheter, guidewires with self-expanding distal tips, and wash-out elements to facilitate rapid removal of stones through an access sheath.

Abstract: Intravascular delivery system for deployment of a therapeutic device, such as a stent, in a controlled and robust manner is supported by a lockable balloon catheter equipped with a locking mechanism configured to lock in vivo to a delivery component, such as a guidewire. The lockable balloon catheter can be controllably transitioned between a locked and an unlocked modes of operation by inflation/deflation of the balloon of the lockable balloon catheter. Being in the locked mode of operation, the lockable balloon catheter facilitates delivery of the therapeutic element along the delivery component to a target site while enhancing the stability of the delivery component, especially near the target site.

Abstract: A surgical instrument such as for use in vitreoretinal surgeries is described. The surgical instrument may include a pair of pincers resiliently biased toward an opened configuration and being movable toward each other into a closed configuration to engage a membrane. Each pincer may include a rounded grasping edge. The grasping edges may include a textured surface operable to induce a capillary effect between a membrane and the forceps to promote adhesion therebetween.

Abstract: In order to provide a simple device for positioning sterile instruments, particularly puncture needles, injection needles or surgical probes, with respect to a patient (P), where said device comprises a sheath (3) at least the inside of which is sterile and which at least partially encompasses a sterile instrument (2), as well as at least one gas-tight feedthrough provided on said sheath (3), it is suggested that the sterile instrument (2) has at least one sterile instrument holder (2?) and that, by moving the instrument holder (2?) outside of the sheath (3), said instrument may be moved in a controlled manner in at least two spatial directions.

Abstract: Described here are devices, systems and methods for closing the left atrial appendage. Some of the methods described here utilize one or more guide members having alignment members to aid in positioning of a closure device. In general, these methods include advancing a first guide having a first alignment member into the left atrial appendage, advancing a second guide, having a second alignment member, into the pericardial space, aligning the first and second alignment members, advancing a left atrial appendage closure device into the pericardial space and adjacent to the left atrial appendage, and closing the left atrial appendage with the closure device. In these variations, the closure device typically has an elongate body having a proximal end and a distal end, and a closure element at least partially housed within the elongate body. The closure element comprises a loop defining a continuous aperture therethrough.

Abstract: Disclosed herein is a stent which includes stent ring structures made up of at least one wire and at least one tubular connector through which a portion of the wire is disposed. The tubular connector includes a side wall with an aperture formed therethrough. A portion of the wire extends therethrough and acts as a barb. A method of making such a stent is also disclosed.

Abstract: A surgical instrument comprising an end effector is disclosed. The end effector comprises a surgical dissector.

Abstract: The disclosed technology is directed to a medical instrument comprises a first pulley configured to be rotatable about a rotational shaft. A transmitting member having a first end portion and a second end portion. The first end portion is disposed along an outer circumferential surface of the first pulley and the second end portion extends tangentially to the first pulley and away from the first pulley. The transmitting member being capable of rotating the first pulley upon being actuated to move forwardly or rearwardly in longitudinal directions thereof. A dislodgement guard is disposed on at least one side of the first pulley along a direction in which the rotational shaft extends with respect to the second end portion of the transmitting member for preventing the transmitting member from being dislodged off the first pulley.

Abstract: A system and method used to deliver a therapeutic device to a target treatment site in the heart includes a cable percutaneously introduced a cable into a vasculature of a patient and positioned to run from a femoral vein, through the heart via a transseptal puncture, and to a femoral artery. The therapeutic device is passed over an end of the cable at the venous side and is secured to the cable. The therapeutic device is pushed in a distal direction while the second end of the cable is pulled in the proximal direction to advance the therapeutic device to the target treatment site. A left ventricle redirector aids in orienting the therapeutic device and preventing migration of the cable towards delicate mitral valve structures and chordae tendoneae during advancement of the therapeutic device.

Abstract: A knotless suture anchor construct for securing a tissue in a desired position relative to a bone hole. The construct includes an anchor body extending between first and second ends and having first and second sides. The construct also includes a filament having a first end and a second end. The filament is woven through a plurality of passing locations along the anchor body such that the first end of the filament extends from the first end of the anchor body and the second end of the filament extends from the second end of the anchor body. The construct additionally includes a first loop in the filament between a first adjacent pair of the plurality of passing locations and a second loop in the filament between a second adjacent pair of the plurality of passing locations. In a pre-deployment configuration, the second loop extends through the first loop.

Abstract: Medical devices for delivering compositions or medical articles to a patient are disclosed. The medical plug delivery devices can include a fluid delivery device (e.g., a syringe), a frame, and a rotatable magazine. The rotatable magazine can include a plurality of chambers that each hold a composition or a medical article (e.g., a medical plug). By rotating the rotatable magazine relative to the frame, material within the chambers of the rotatable magazine can be sequentially deployed to a patient.

Abstract: An ultrasonic surgical instrument includes a first modular assembly including at least one operator input feature an ultrasonic transducer supported by the first modular assembly, and a second modular assembly configured to be removably coupled with the first modular assembly. The second modular assembly includes at least a portion of an end effector extending distally from a distal end portion of the second modular assembly. The instrument includes a mechanical lockout assembly configured to switch between at least an unlocked configuration and a locked configuration. In the locked configuration, the first modular assembly and the second modular assembly are partially coupled together such that the operator is physically prevented from activating the instrument using the operator input feature. In the unlocked configuration, the first modular assembly and the second modular assembly are completely coupled together and the operator is able to activate the instrument using the operator input feature.

Abstract: A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Abstract: The problem of positioning one or more nerve ends inside a sheathing implant is solved by the use of a pulley and cinching systems that pull a nerve end into an implant and that can adjust the diameter of an implant to conform the implant to the diameter of the nerve, respectively. The pulley system utilizes a suture that traverses the wall of an implant leaving one end outside the implant wall and another end that can be attached to a nerve. Pulling the suture end outside the wall pulls the nerve attached to the other end of the suture into the bore of the implant. A cinching system utilizes specially arranged sutures within the wall of an implant to tighten or cinch up the wall after a nerve is placed therein, so as to conform at least part of the implant to the diameter of the nerve. Methods are also disclosed by which such pulley systems can be formed during an intraoperative procedure.

Abstract: A stent coupler for use with a medical device delivery system is disclosed. A stent delivery system includes a core member having a distal segment and a coupler positioned about the core member distal segment. the coupler is rotatably coupled to the core member and includes a rigid plate having a first end surface, a second end surface, and a side surface extending between the first and second end surfaces, the side surface comprising one or more projections separated by recesses. The delivery system further includes a stent extending along the core member distal segment such that an inner surface of the stent is engaged by the one or more projections of the engagement member.

Abstract: An anchorage device includes a substrate extending along a longitudinal axis between a first end having a first bonding area and an opposite second end having a second bonding area. The substrate has a third bonding area between the first and second bonding areas. Kits, systems and methods are disclosed.