Patents Examined by Gerald Ewoldt
  • Methods of activating NKT cells
    Patent number: 7998739
    Abstract: Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: August 16, 2011
    Assignees: The Scipps Research Institute, Brigham Young University, The University of Chicago
    Inventors: Albert Bendelac, Dapeng Zhou, Luc Teyton, Paul Savage
  • Human binding molecule against CD1a
    Patent number: 7968092
    Abstract: The present invention provides human binding molecules that specifically bind to CD1a, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used in the diagnosis, prevention and treatment of neoplastic disorders and diseases.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: June 28, 2011
    Assignees: Crucell Holland B.V., The Johns Hopkins University
    Inventors: Mark Throsby, Marja van Meijer, Wilfred T. V. Germeraad, Robert J. Arceci, Ada M. Kruisbeek