Patents Examined by GiGi Huang
  • Polymeric quaternium compounds
    Patent number: 8349303
    Abstract: A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II wherein Ck is a saturated or unsaturated, five, six or seven-membered ring; R is a C1-C3alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: January 8, 2013
    Assignee: Bausch & Lomb Incorporated
    Inventors: Eric Phillips, Jay F. Kunzler, Alok Kumar Awasthi
  • Skin sanitizing antimicrobial alcoholic compositions
    Patent number: 8329758
    Abstract: This invention relates to an antimicrobial skin sanitizing composition for disinfecting skin, and particularly, hands. The composition contains at least 60 percent of an aliphatic alcohol having from 1 to 4 carbon atoms, from about 0.1 to about 5 weight percent of a thickening agent, and an effective amount of a GRAS or amino acid neutralizer to neutralize the thickening agent.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: December 11, 2012
    Assignee: GOJO Industries, Inc.
    Inventors: Yusuf Ali, Ronald A. Barnhart, Mojgan Cline
  • Methods for the treatment and prevention of age-related retinal dysfunction
    Patent number: 8324270
    Abstract: A method of treating or preventing age-related retinal dysfunction involves administering to a patient a pharmaceutically effective amount of a synthetic retinal derivative repeatedly over a duration of at least about 3 months. Effective synthetic retinal derivatives include 9-cis-retinyl esters, 11-cis-retinyl esters, derivatives and congeners thereof, and combinations thereof. Suitable ester substituents include carboxylates of C1-C10 monocarboxylic acids and C2-C22 polycarboxylic acids.
    Type: Grant
    Filed: February 10, 2009
    Date of Patent: December 4, 2012
    Assignee: University of Washington
    Inventors: Tadao Maeda, David Saperstein, Krzysztof Palczewski
  • Therapeutic compositions and methods
    Patent number: 8318741
    Abstract: The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: November 27, 2012
    Assignee: The Texas A & M University System
    Inventor: George C. Chiou
  • Aqueous intraocular penetration-promoting eye drop
    Patent number: 8299124
    Abstract: An aqueous eye drop comprising 2-amino-3-(4-bromobenzoyl)phenylacetic acid or its pharmacologically acceptable salt or a hydrate thereof and an organic amine (for example, aminoethylsulfonic acid or trometamol) or a salt thereof is useful as an eye drop for once a day administration for treating inflammatory diseases of the external segment or the anterior segment of the eyes, since such aqueous eye drop can maintain a therapeutically effective concentration of 2-amino-3-(4-bromobenzoyl)phenylacetic acid in anterior aqueous humor for at least 24 hours by once a day administration.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: October 30, 2012
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Shirou Sawa, Tomoko Fujimoto
  • Intraocular implants and methods for improving vision
    Patent number: 8293741
    Abstract: Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, among others or to improve vision in a normal eye.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: October 23, 2012
    Assignee: Allergan, Inc.
    Inventors: James A. Burke, Patrick M. Hughes, Kai-Ming Zhang, Ton Lin, Glenn Huang, Brittany A. Jackson, Larry A. Wheeler, Rosy S. Donn
  • Saline solutions for clinical or cosmetic use
    Patent number: 8236863
    Abstract: A saline solution for a clinical or cosmetic use which consists essentially of a solution in water of sodium ions in major amount and potassium ions in minor amount, together with physiologically acceptable counter ions, being isotonic or optionally slightly hypertonic or hypotonic with respect to blood plasma or tears or an otherwise relevant biological fluid, and being substantially free of calcium ions, magnesium ions, phosphate ions, bicarbonate ions and also glucose, sucrose, food starch or other glucose-releasing saccharides, for use as a more cell-friendly alternative to normal saline.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: August 7, 2012
    Assignee: Pharma Sol International Limited
    Inventors: Ryszard Jan Schmidt, James Martin Biggs
  • Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection
    Patent number: 8211880
    Abstract: Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-guage needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: July 3, 2012
    Assignee: Alcon Research, Ltd.
    Inventors: Bhagwati P. Kabra, Ruma Sarkar
  • Ophthalmic composition
    Patent number: 8211450
    Abstract: The present invention provides an ophthalmic composition comprising a hyperbranched polymer. The ophthalmic compositions may also comprise carbonic anhydrase inhibitors, wherein the hyperbranched polymer increases the aqueous solubility of the carbonic anhydrase inhibitor, and increases corneal permeation of the active agent. The ophthalmic compositions may also comprise non-ionic surfactants, such as polysorbate, hydroxypropyl methyl cellulose or hydroxyethyl cellulose, and beta-blockers, such as carteolol, levobunolol, betaxolol, metipranolol, timolol or propranolol.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: July 3, 2012
    Assignee: Senju USA, Inc.
    Inventors: Jun Inoue, Tapan Shah
  • Pharmaceutical composition
    Patent number: 8178518
    Abstract: A pharmaceutical composition comprising: (A) an androgen; (B) a cyclic enhancer of the type used in the compositions and methods claimed by U.S. Pat. No. 5,023,252 to Hsieh; and (C) a thickening agent; including, for example, a composition in which the cyclic enhancer is a macrocyclic ester or a macrocyclic ketone; the use of the composition to treat a condition, for example, male hypogonadism, in a patient by applying the composition to the membrane of the patient; and a method for making the composition.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 15, 2012
    Assignee: FCB I LLC
    Inventor: Robert J. Gyurik
  • Compositions and methods for treatment of eye disorders
    Patent number: 8168655
    Abstract: The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: May 1, 2012
    Assignee: SARcode Bioscience Inc.
    Inventors: Thomas Gadek, John Burnier
  • Medicinal preparation particularly for the treatment of slipped discs hernias
    Patent number: 8153696
    Abstract: The invention concerns a product consisting in an injection medicinal formulations comprising at least one compound to provide a viscous formulation, ethanol and at least one compound making said formulation opaque to X rays so as to control its delivery and its action. Said formulation is in particular useful for treating herniated invertebral discs but also in intervention having demonstrated the efficacy of pure ethanol: treatment of hepatocellular tumours or osteoid osteomas, renal cysts and arterial-veinous angiomas.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 10, 2012
    Inventors: Jacques Theron, Marc d'Aboville, Christine Marie Joseph D'Aboville, legal representative, Soline Alix Marie D'Aboville, legal representative, Côme Philippe Guy D'Aboville, legal representative, Quentin Bruno Pierre D'Aboville, legal representative, Grégoire Michel Séverin D'Aboville, legal representative
  • Medicament-containing particle and a solid preparation containing the particle
    Patent number: 8153161
    Abstract: The invention provides a medicament-containing particle wherein an unpleasant taste of the medicament is alleviated, which is obtainable by mixing and granulating the following ingredients: (1) the medicament with an unpleasant taste, (2) methylcellulose and (3) mannitol; and a solid preparation including the particle. The invention can make an unpleasant taste of the medicament alleviated and furthermore when the formulation including the particle is administered, the unpleasant taste can be masked and the formulation has a good dissolvability in gastrointestinal tract.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: April 10, 2012
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Keiichi Fujiwara, Kiyomi Sogo, Shizuo Okamoto, Koichiro Shibamori, Norihito Shimono
  • Low viscosity, highly flocculated triamcinolone acetonide suspensions for intravitreal injection
    Patent number: 8128960
    Abstract: Triamcinolone acetonide suspension compositions are disclosed. The suspension compositions have a relatively low viscosity and are easy to extrude through a 27- or 30-gauge needle but are highly flocculated and easily redispersed. The compositions are particularly suitable for intravitreal injection.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: March 6, 2012
    Assignee: Alcon Research, Ltd.
    Inventors: Bhagwati P. Kabra, Ruma Sarkar
  • Sunscreen formula vanishing cream
    Patent number: 8119698
    Abstract: A cosmetic composition is provided which is a vanishing cream structured with 0.5 to 50% by weight of C12-C20 fatty acid, 0.1 to 20% by weight of C12-C20 fatty acid salt and hydrophilic composite particles with organic sunscreen agent. The hydrophilic composite particles are formed as a composite of sunscreen agent and a binder in a relative weight ratio of about 5:1 to about 1:10. The composition exhibits relatively high SPF photoprotection while maintaining excellent skinfeel aesthetics.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: February 21, 2012
    Assignee: Conopco, Inc.
    Inventors: Jack Polonka, Xiaoling Wei, John Brian Bartolone
  • Composition for treating dry eye and related methods of manufacture and methods of use
    Patent number: 8114420
    Abstract: The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: February 14, 2012
    Assignee: Bausch & Lomb Incorporated
    Inventors: Erning Xia, Joseph Salamone, X. Michael Liu
  • Dosage unit comprising a prostaglandin analog for treating constipation
    Patent number: 8097653
    Abstract: A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention comprises a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: January 17, 2012
    Assignee: Sucampo AG
    Inventors: Ryuji Ueno, Myra L. Patchen
  • Therapeutic compositions and methods
    Patent number: 8088773
    Abstract: The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by administering compounds disclosed herein. In some embodiments, the invention relates to compositions and methods of improving vision.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: January 3, 2012
    Assignee: The Texas A&M University System
    Inventor: George C. Chiou
  • Compositions and methods for treatment of eye disorders
    Patent number: 8084047
    Abstract: The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: December 27, 2011
    Assignee: Sarcode Bioscience Inc.
    Inventors: Wang Shen, Johan D. Oslob, Kenneth Barr, Min Zhong
  • Triple-action remedy for removing toxic oils from skin with simultaneous soothing and healing
    Patent number: 8067358
    Abstract: Disclosed are formulae and methods for the simultaneous relief of a variety of unpleasant symptoms of poison ivy on the skin. The compositions of the present invention remove toxic urushiol, relieve itching of the skin from urushiol, and heal the dermatitis caused by urushiol. A preferred embodiment of the invention is a topical dosage form which can be applied as often as desired, may be scrubbed onto the skin, and leaves a soothing effect on the skin after rinsing with warm water.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: November 29, 2011
    Assignee: Tec Laboratories, Inc.
    Inventors: Robert Lee Smith, John Mark Christiansen, Wendy S Langley, Vernon W. Smith, Brian Chipman