Patents Examined by Gillian C. Reglas
  • Patent number: 11987808
    Abstract: The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells. Specifically described are methods to direct the lineage specific differentiation of hiPSC to sensitive neurons or neuronal fibers innervating the human skin, such as neural crest stem cells (NCPCs) and here called peripheral sensory neurons (PSNs) using novel culture conditions. It is also described a method for screening a biological agent in vitro. The PSNs obtained using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro tests or disease modelling, such as drug discovery assays, cell therapy on a higher scale, detecting a range of skin irritants and other compounds of interest, for studying skin aging mechanism, and for producing a dermocosmetic product.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 21, 2024
    Assignee: L'OREAL
    Inventors: Rodrigo De Vecchi, Stevens Kastrup Rehen, Marilia Zaluar, Lionel Breton