Patents Examined by Ginny Allen Portner
  • Two-step immunization procedure against Chlamydia infection
    Patent number: 6676949
    Abstract: A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a high level of protection to be achieved.
    Type: Grant
    Filed: December 3, 1999
    Date of Patent: January 13, 2004
    Assignees: University of Manitoba, Aventis Pasteur Limited
    Inventors: Robert C. Brunham, Andrew D. Murdin
  • Washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof
    Patent number: 6664070
    Abstract: A washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: December 16, 2003
    Assignee: Dade Behring Marburg GmbH
    Inventor: Hans-Detlef Dopatka
  • Attenuated live neospora vaccine
    Patent number: 6656479
    Abstract: The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: December 2, 2003
    Assignee: Pfizer Inc.
    Inventors: David A Brake, Byron L Blagburn, David S Lindsay
  • One-step lateral flow assays
    Patent number: 6656744
    Abstract: The efficiency and accuracy of one-step lateral flow assays can be improved by employing more efficient binding between participants in labeling and capture. Thus, in addition to analyte/anti-analyte interactions, specific binding is achieved through members of an irrelevant specific binding pair. Also included within the invention is a format wherein unlabeled competitor for analyte serves as a gatekeeper in the capture zone, competing with analyte for labeled anti-analyte, which analyte will be captured in a detecting portion of a capture zone.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: December 2, 2003
    Assignee: Quidel Corporation
    Inventors: Allan D. Pronovost, Hans Boehringer, Ya-Chen Hsu
  • Tyrosine-containing cyclophilin and related methods
    Patent number: 6649395
    Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as ‘tyrosine-containing’ cyclophilins, in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 18, 2003
    Assignee: New England Biolabs, Inc.
    Inventors: Clotilde K. S. Carlow, Xiqiang Hong, Dong Ma
  • Escherichia coli secreted protein B
    Patent number: 6635259
    Abstract: Several EHEC proteins which are secreted into the culture supernatant have been discovered. These proteins are not produced by non-pathogenic E. coli, and produce a strong serum antibody response in patients with HUS and bloody diarrhea.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: October 21, 2003
    Assignee: University of Maryland, Baltimore
    Inventors: James B. Kaper, Karen Jarvis
  • Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same
    Patent number: 6632431
    Abstract: The present invention relates to an anti-idiotypic antibody or antigen-binding fragment against FimH adhesin of uropathogenic Type I-fimbriated Escherichia coli and an immunizing composition containing such an anti-idiotypic antibody or antigen-binding fragment thereof as an active immunizing component. The present invention also relates to a method for stimulating and enhancing the production of antibodies which recognize and bind to FimH of uropathogenic Type-I-fimbriated Escherichia coli, but not to FimH of non-uropathogenic Type I-fimbriated Escherichia coli.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: October 14, 2003
    Assignee: New York University
    Inventor: Xue-Ru Wu
  • Treatment and prevention of helicobacter infection
    Patent number: 6630582
    Abstract: An antigenic preparation for use in the treatment or prevention of Helicobacter infection in a mammalian host, comprises the catalase enzyme of Helicobacter bacteria, particularly the catalase enzyme of H. pylori or H. felis, or an immunogenic fragment thereof.
    Type: Grant
    Filed: January 7, 1998
    Date of Patent: October 7, 2003
    Assignees: University of New South Wales, CSL Limited
    Inventors: Christopher V. Doidge, Adrian Lee, Flona J. Radcliff, Stuart L. Hazell
  • Solid-phase activity assay for biologically active substance
    Patent number: 6610494
    Abstract: A method of detecting via a solid-phase assay the amount of biological activity, identity and/or the quantity of a biologically active substance is disclosed. The method utilizes the biological activity of the substance itself to provide the method of detection. The method provides competitive and noncompetitive assays.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: August 26, 2003
    Inventors: Ronald R. Marquardt, Xiao Hao, Guojie Wang, Zhiqun Zhang, Zhibo Gan
  • Methods and means of detecting nitric oxide synthase
    Patent number: 6605447
    Abstract: Methods for identifying and monitoring increased or decreased levels of inducible nitric oxide synthase in biological samples are provided. A collection device for detecting inducible nitric oxide synthase in biological samples is also provided. Detection of inducible nitric oxide synthase is useful in the diagnosis of inflammatory responses such as infections mediated by bacteria, yeast or viruses, transplant rejection, rheumatoid arthritis, interstitial cystitis and cancer.
    Type: Grant
    Filed: September 14, 1998
    Date of Patent: August 12, 2003
    Assignee: Yale University
    Inventors: Robert M. Weiss, William C. Sessa, Marcia A. Wheeler, Shannon D. Smith
  • Adherence gene from Helicobacter pylori and polypeptide coded thereby
    Patent number: 6593461
    Abstract: The present invention concerns an adherence gene from Helicobacter pylori, a polypeptide coded thereby and antibodies against the polypeptide.
    Type: Grant
    Filed: December 10, 1997
    Date of Patent: July 15, 2003
    Assignee: Max-Planck-Gesellschaft zur Föderung der Wissenscaften e.v.
    Inventors: Rainer Haas, Stefan Odenbreit, Thomas F. Meyer, André Blum, Irène Corthésy-Theulaz
  • Protein rib, a cell surface protein that confers immunity to many strains of the group B Streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition
    Patent number: 6586580
    Abstract: This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: July 1, 2003
    Inventors: Gunnar Lindahl, Margaretha Stalhammar-Carlemalm, Lars Stenberg
  • Use of Salmonella vectors for vaccination against helicobacter infection
    Patent number: 6585975
    Abstract: The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: July 1, 2003
    Assignee: Acambis, Inc.
    Inventors: Harold Kleanthous, Patricia Londono-Arcila, Donna Freeman, Cynthia K. Lee, Thomas P. Monath
  • Flagellin gene, FlaC of Campylobacter
    Patent number: 6585980
    Abstract: Purified and isolated nucleic acid molecules are provided which encode a FlaC flagellin protein of a strain of Campylobacter, particularly C. jejuni, or a fragment or an analog of the FlaC flagellin protein. The nucleic acid molecules may be used to produce proteins free of contaminants derived from bacteria normally containing the FlaA or FlaB proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules, proteins encoded thereby and antibodies raised against the proteins, may be used in the diagnosis of infection.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: July 1, 2003
    Assignee: The University of Toronto
    Inventors: Voon Loong Chan, Helena Louie
  • Simple immunochemical semi-quantitative assay method and apparatus
    Patent number: 6582970
    Abstract: The present invention relates to a simple immunochemical semi-quantitative assay method according to chromatography, which comprises trapping a certain amount of an analyte in a sample with a predetermined amount of a fixed antibody for the analyte before qualitative analysis of the analyte, the certain amount corresponding to the amount of the fixed antibody, and thereby decreasing a concentration of the analyte to be subjected to subsequent immunochemical qualitative determination, and an apparatus therefor.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: June 24, 2003
    Assignee: Teikoku Hormone MFG. Co, Ltd.
    Inventor: Hideaki Manita
  • LT and CT in parenteral immunization methods against helicobacter infection
    Patent number: 6576244
    Abstract: This invention provides methods of inducing a protective or therapeutic immune response to Helicobacter infection in a mammal by parenterally administering to the mammal one or more Helicobacter antigens and an adjuvant selected from one or more of LT, CT, LTB, and CTB.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: June 10, 2003
    Assignee: Acambis, Inc.
    Inventors: Richard A. Weltzin, Bruno Guy
  • Adjuvants for use in vaccines
    Patent number: 6572861
    Abstract: The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: June 3, 2003
    Inventors: David S. Roberts, Leroy A. Swearingin, Don A. Dearwester
  • Determination of recombinant glycosylated proteins and peptides in biological fluids
    Patent number: 6573055
    Abstract: Polyclonal antibodies can be produced that reacts with recombinant EPO and its degradation products but not with native EPO. This antibody precipitation can be used to identify those glycopeptides that are uniquely reactive. These glycopeptides can be produced on preparative scale and used in the production of monoclonal antibodies which are screened against the original EPO and glycopeptides to select antibodies reactive to the specific glycopeptides an recombinant EPO but not to native human EPO. The monoclonal antibodies so selected are incorporated in a conventional ELISA and used to monitor urine and other bodily samples taken from athletes, either human or animal, and patients for presence and level of recombinant peptides or proteins. Alternatively, the polyclonal antibody can be used directly to produce ELISA tests.
    Type: Grant
    Filed: April 21, 1998
    Date of Patent: June 3, 2003
    Assignee: Glycozyme, Inc.
    Inventor: Allen K. Murray
  • Dihydroxypropyl cysteine peptide and agent containing this peptide
    Patent number: 6573242
    Abstract: The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following sequence: Dhc GN NDE SNI SFK EK (SEQ ID No 1)     1    5     10 The invention relates also to a composition comprising the mentioned peptide.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: June 3, 2003
    Assignee: Gesellschaft fuer Biotechnologische
    Inventor: Peter F. Muehlradt
  • dapE gene on Helicobacter pylori and dapE? mutant strains of Helicobacter pylori
    Patent number: 6570004
    Abstract: The invention provides the dapE gene of Helicobacter pylori and H. pylori dapE− mutants and to methods of using the mutants to express foreign genes and immunize against foreign agents. The dapE gene can consist of the nucleotide sequence defined in SEQ ID NO:3. Nucleic acids of the gidA gene and ORF 2 of H. pylori are provided. Examples of these nucleic acids can be found in SEQ ID NO:1 and SEQ ID NO:5, respectively. Having provided these nucleic acids, hybridizing nucleic acids in accord with the description of hybridizing nucleic acids of dapE are also provided.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: May 27, 2003
    Assignee: Vanderbilt University
    Inventors: Martin J. Blaser, Mikio Karita