Abstract: Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
Type:
Grant
Filed:
January 27, 2006
Date of Patent:
August 21, 2007
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N Beatch, Bertrand M C Plouvier, Tao Sheng, Michael J A Walker, Richard A Wall, Sandro L Yong, Jeff Jiqun Zhu, Alexander B Zolotoy
Abstract: The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.
Type:
Grant
Filed:
June 29, 2004
Date of Patent:
August 7, 2007
Assignee:
President and Fellows of Harvard College
Inventors:
Junying Yuan, Alexei Degterev, Timothy J. Mitchison
Abstract: The present invention is directed to the field of substituted tetrazole synthesis and manufacture. More particularly, the present invention is directed to processes for preparing substituted tetrazoles and tetrazolate salts, such as sodium nitrotetrazolate and sodium cyanotetrazolate, using small scale and/or microreactor techniques. The use of the present techniques result in less hazardous and more efficient manufacturing processes.
Type:
Grant
Filed:
September 8, 2005
Date of Patent:
August 7, 2007
Assignee:
Pacific Scientific Energetic Materials Company
Inventors:
Robert N. Renz, Michael D. Williams, John W. Fronabarger
Abstract: The present invention describes a process for preparing N-substituted phthalimides of Formula I which are widely useful as intermediates in the preparation of organic compounds such as pharmaceuticals
Abstract: This invention relates to the provision of novel aminomethyl-substituted thiazolobenzimidazole derivatives represented by the following general formula (I) or a salt thereof. The aforementioned derivative or a salt thereof has a metabotropic glutamate receptor action and excellent oral activity and is therefore useful as a medicament. (In the formula, R1: an oxygen-containing saturated hetero ring or the like, Alk1: a lower alkylene, m: 0 or 1, Alk2: a lower alkylene which may be substituted with oxo group, n: 0 or 1, X: a bond, O, S or NR5, R3: H or the like, and R2, R4, R5, R6 and R7: the same or different from one another and each represents H or the like. Provided that R3 does not represent a lower alkyl or a halogeno-lower alkyl when X is a bond and n is 1. Also, R4 represents a group other than Me when m is 1, R1 is OH or OMe and Alk1 is a C1-3 alkylene, and further 1) when X is a bond, n is 1 and R3 is H, or 2) when X is a bond, n is 0 and R3 is cyclohexane.
Abstract: A process for preparing alkoxypyrazine derivatives of the general formula:
These alkoxypyrazine derivatives are obtained by reacting a glyoxal derivative of the general formula:
and an aminoimidate of the general formula:
Abstract: This invention provides novel compounds and pharmaceutical compositions and methods of using the compounds in the treatment of central nervous system disorders, such as anxiety and depression, the compounds having the formula I:
wherein:
X is N—R, O, S(O)m; m is 0 to 2; n is 0 to 4; Ar is an aryl group of 6 to 12 carbon atoms optionally substituted with 1 to 3 R3 groups, or a heteroaryl group of 4 to 10 carbon atoms optionally substituted with 1 to 3 R3 groups;
R and R2 are independently H, straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, alkoxycarbonyl of 1 to 6 carbon atoms, alkylcarbonyl of 1 to 6 carbon atoms, aminocarbonyl, or alkylaminocarbonyl of 1 to 4 carbon atoms;
R1 and R3 are independently H, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, halo, alkoxy group of 1 to 4 carbon atoms, haloalkyl of 1 to 4 carbon atoms, OH, nitro, amino,
Type:
Grant
Filed:
November 6, 2000
Date of Patent:
June 12, 2001
Assignee:
American Home Products Corp
Inventors:
Magda Asselin, John W. Ellingboe, Richard E. Mewshaw