Abstract: Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
Type:
Grant
Filed:
December 5, 1996
Date of Patent:
July 14, 1998
Assignee:
Atrix Laboratories, Inc.
Inventors:
Gerald L. Yewey, Nancy L. Krinick, Richard L. Dunn, Michael L. Radomsky, Gerbrand Brouwer, Arthur J. Tipton
Abstract: A bilayer comprising a morphine layer of morphine, poly(alkylene oxide) and poly(vinylpyrrolidone); and an expandable contacting layer of coated granules of a higher molecular weight poly(alkylene oxide) and a hydroxyalkylcellulose, which bilayer is disclosed for morphine therapy. A method is disclosed for using the bilayer composition.
Type:
Grant
Filed:
June 27, 1994
Date of Patent:
October 24, 1995
Assignee:
Alza Corporation
Inventors:
Sonya Merrill, Atul D. Ayer, Paul Hwang, Anthony L. Kuczynski