Abstract: Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 ?m. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
Type:
Grant
Filed:
March 29, 2010
Date of Patent:
August 12, 2014
Assignee:
Insmed Incorporated
Inventors:
Lawrence T. Boni, Brian S. Miller, Vladimir Malinin, Xingong Li
Abstract: The present invention provides compositions and methods for the treatment of a human patient. The methods and compositions of the present invention include composition for the efficient loading of curcumin, comprising: an amount of a curcuminoid:liposome complex effective to load curcumin into the liposome, wherein the curcuminoids has between 2 to 9 weight percent of the total composition and the curcuminoids are natural or synthetic.
Type:
Grant
Filed:
December 1, 2007
Date of Patent:
July 22, 2014
Assignees:
Board of Regents, The University of Texas System, SignPath Pharma Inc.
Inventors:
Razelle Kurzrock, Lan Li, Kapil Mehta, Bharat Bhushan Aggarawal, Lawrence Helson
Abstract: The combination of pentraxin PTX3 with antifungal agents is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus. Thanks to the synergistic effect of the two drugs, the combination allows the administration of suboptimal doses of antifungal agent.
Abstract: The present invention provides a nano-micellar preparation containing vinca alkaloids antitumor agent for intravenous injection, which cincludes a therapeutically effective amount of vinca alkaloids antitumor agent (vinblastine, vincristine, vindesine and vinorelbine), a phosphatide derivatized with polyethylene glycol, together with pharmaceutically acceptable adjuvants. The preparation is prepared by encapsulating the medicament with a nano-micelle to obtain the nano-micellar preparation containing vinca alkaloids antitumor agent for injection. The vinca alkaloids antitumor agent and the phosphatide derivatized with polyethylene glycol form a nano-micelle with a highly uniform particle size.
Type:
Grant
Filed:
September 8, 2006
Date of Patent:
July 1, 2014
Assignee:
Beijing Diacrid Medical Technology Co., Ltd
Abstract: A therapeutic method is described in which copper is delivered into the skin as a complex with sodium chlorophyllin. Sodium copper chlorophyllin is encapsulated in suitable lecithin-type liposomes, containing a high concentration of linoleic acid and having diameters in the range 150-350 nanometers. The method provides therapeutic benefits in the treatment of environmentally-induce premature skin aging, excessively oily skin, acne and acne-related skin disorders, acne-rosacea, and also stimulates the natural tanning response of skin to sunlight and other ultraviolet-containing radiation.
Type:
Grant
Filed:
June 11, 2010
Date of Patent:
June 24, 2014
Assignee:
CHL Industries, LLC
Inventors:
Peter Ladislaus Dorogi, David Bruce Vasily, John Patrick McCook
Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
Type:
Grant
Filed:
July 25, 2013
Date of Patent:
June 10, 2014
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
Abstract: Compositions and methods for treating systemic diseases by intravenous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly a calcium channel blocker to human subjects with neoplastic and neurodegenerative diseases are disclosed herein. The diseases are treated by prolonged administration of sub-optimal doses of liposomal curcumin or polymeric nanocurcumin or the sustained release curcumin from PLGA nanocurcumin at dosages below systemic hemolytic thresholds concomitantly with or without calcium channel blockers.
Abstract: This invention relates to the targeted delivery of hydrophobic drugs or combinations of hydrophobic drugs with photodynamic therapy agents to vascular lesions by complexation of the drugs to blood serum lipoproteins, which have an affinity for and accumulate in such vascular lesions.
Type:
Grant
Filed:
January 28, 2009
Date of Patent:
April 29, 2014
Assignee:
Abbott Cardiovascular Systems Inc.
Inventors:
Dariush Davalian, John Stankus, Yuet Mei Khong, O. Mikael Trollsas, Syed F. A. Hossainy
Abstract: A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.
Type:
Grant
Filed:
May 1, 2007
Date of Patent:
April 15, 2014
Assignees:
Johns Hopkins University, The Board of Trustees of the Leland Stanford Junior University
Inventors:
Corinne Bright, Rachel Bright, Eric Churchill, Kam W. Leong, Daria Mochly-Rosen
Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.
Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
Type:
Grant
Filed:
July 23, 2013
Date of Patent:
April 1, 2014
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
Abstract: The invention proposes the sure of reduced glutathione in a liposome (liposomal reduced glutathione) for the oral administration of a therapeutically effective amount to ameliorate the progression of vascular disease, including atherosclerosis, diabetes, hypertension, narrowing of arteries leading to decreased blood flow, ischemic events, and the formation of blood clots, abnormal platelet aggregation, and thrombotic events, by reducing the amount and effect of oxidized cholesterol, oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with statin drugs to improve the effect of lowering not only cholesterol but also the oxidized cholesterol as well as oxidized HDL and oxidized LDL. The invention also proposes combining liposomal encapsulated glutathione with CoQ10 as a therapy for vascular disease and management of side effects of statin therapy.
Type:
Grant
Filed:
October 26, 2006
Date of Patent:
March 25, 2014
Assignee:
Your Energy Systems, LLC
Inventors:
F. Timothy Guilford, Brooke Schumm, III
Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention. The present invention also provides for the methods and kits for the delivery of liposomal compositions to the brain.
Abstract: The invention relates generally to methods of making formulations for delivering biological agents to a patient. In one aspect, proliposomal drug-delivery systems for medicaments are provided. In another aspect, coated proliposomal formulations for poorly water soluble drugs, and methods for making the same, are provided. Certain embodiments of the present invention provide enhanced stability and bioavailability for pharmaceutical formulations.
Abstract: The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.
Type:
Grant
Filed:
August 1, 2011
Date of Patent:
February 25, 2014
Assignee:
Lantheus Medical Imaging, Inc.
Inventors:
Poh K. Hui, John E. Bishop, Eleodoro S. Madrigal, Jr.
Abstract: Provided herein are methods for preparing liposomes comprising docetaxel and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.
Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
Type:
Grant
Filed:
September 10, 2012
Date of Patent:
September 17, 2013
Assignees:
Varian Medical Systems, Inc., Arizona Board of Regents on Behalf of the University of Arizona
Inventors:
David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
Abstract: Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to a non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.
Type:
Grant
Filed:
November 13, 2002
Date of Patent:
August 27, 2013
Assignee:
Celator Pharmaceuticals, Inc.
Inventors:
Paul Tardi, Murray Webb, Lawrence D. Mayer, Ludger M. Ickenstein
Abstract: Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.
Type:
Grant
Filed:
November 25, 2009
Date of Patent:
August 27, 2013
Assignees:
Albany College of Pharmacy and Health Services, Orway Research Institute, Inc.
Inventors:
Shaker A. Mousa, Faith B. Davis, Paul J. Davis
Abstract: The invention provides a formulation of water insoluble or poorly water soluble drugs encapsulated in lipidated glycosaminoglycan particles for targeted drug delivery.
Type:
Grant
Filed:
March 14, 2012
Date of Patent:
August 6, 2013
Assignee:
Tel-Aviv University Future Technology Development L.P.
Inventors:
Rimona Margalit, Noga Yerushalmi, Dan Peer, Ilia Rivkin