Abstract: Micelles are produced having a membrane wherein the outer surface is hydrophilic and the interior of said micelle contains at least one lipophilic group. If a lipophilic material will not form strong micelles, it is possible, using methods of the invention, to provide stronger micelles by use of two lipophilic materials. These micelles have a glycoprotein layer on the outside with a double layer of lipid wherein the first lipid forms a membrane with the glycoprotein and the second lipid is within the membrane.
Abstract: An improved liposome and related methods for using the liposome to facilitate the delivery of an extracellular agent to the cytoplasm of a target cell are provided. The improved liposomes include a phagosomal membrane permeabilizer, such as a hemolysin.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
July 1, 1997
Assignees:
President and Fellows of Harvard College, University of Pennsylvania
Inventors:
Kyung-Dall Lee, Daniel A. Portnoy, Joel A. Swanson
Abstract: The instant invention is directed to the use of a pharmaceutical composition containing an effective amount of adenosine or an adenosine analog or derivative as an agent useful in the treatment of hormone-independent cancers, such as prostate cancer. The invention is also directed to diagnostic uses of these compounds to determine effective treatment regimes for specific tumors, a process for screening for new, therapeutically useful analogs of these compounds, and the use of these compounds in facilitating the extraction of intracellular components.
Type:
Grant
Filed:
May 15, 1995
Date of Patent:
June 24, 1997
Assignee:
The United States of America as represented by the Department of Health and Human Services
Inventors:
Jane B. Trepel, Wei-Gang Fang, Farzaneh Pirnia, Charles E. Myers, Jr.
Abstract: Disclosed herein is a method for treating autoimmune diseases in mammals by administration of one or more agents selected from the group consisting of autoantigens specific for the autoimmune disease, disease-suppressive fragments and analogs of said autoantigen in aerosol form.
Abstract: Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.
Type:
Grant
Filed:
March 16, 1995
Date of Patent:
December 3, 1996
Assignee:
Alcon Laboratories, Inc.
Inventors:
Stella M. Robertson, Herman M. Kunkle, Jr.
Abstract: Disclosed are heterovesicular liposomes containing substances of different biologically active compositions each encapsulated in separate chambers of the liposomes, having defined size distribution, adjustable average size, adjustable internal chamber size and number, methods of making them, and treatment of patients with them.