Patents Examined by Gollamudi S. Kishore
  • Oral formulations for anti-tumor compounds
    Patent number: 7201913
    Abstract: The present invention relates to a semi-solid filling medium which comprises a camptothecin derivative; a pharmaceutically acceptable carrier matrix which is a polyglycolized glyceride; and an effective thickening-reducing and stabilizing-promoting amount of one or more pharmaceutically acceptable excipients.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: April 10, 2007
    Assignee: Pfizer Inc.
    Inventors: Lorena Muggetti, Alessandro Martini, Paola Civaroli, Christopher James
  • Peptide/lipid complex formation by co-lyophilization
    Patent number: 7189411
    Abstract: The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the peptides and lipids or two separate solutions may be lyophilized.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: March 13, 2007
    Assignee: Jean-Louis Dasseux
    Inventor: Jean-Louis Dasseux
  • Self forming, thermodynamically stable liposomes and their applications
    Patent number: 7150883
    Abstract: A lipid composition forms liposomes spontaneously upon mixing with an aqueous solution. The lipid composition includes diacylglycerol-PEG compounds. Such lipid compositions are useful for forming liposomes, which in turn are useful for a variety of purposes, including the delivery of therapeutic agents.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: December 19, 2006
    Assignee: BioZone Laboratories, Inc.
    Inventors: Brian Charles Keller, Alenka Lasic, legal representative, Dan D. Lasic, deceased
  • Rapidly disintegrating tablet comprising an acid-labile active ingredient
    Patent number: 7147869
    Abstract: A rapidly disintegrating tablet for oral administration of acid-labile active ingredients is described. The rapidly disintegrating tablet for oral administration of an acid-labile active ingredient comprises a plurality of individual active ingredient units together with pharmaceutical excipients, where the acid-labile active ingredient is present in the individual active ingredient units in a matrix composed of a mixture comprising at least one solid paraffin and one or more substances from the group of fatty alcohol, triglyceride and fatty acid ester, and where excipients which, on oral intake of the tablet, bring about rapid disintegration of the tablet are present.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: December 12, 2006
    Assignee: Altana Pharma AG
    Inventors: Rango Dietrich, Hartmut Ney, Rudolf Linder
  • Methods of producing intraocular lenses
    Patent number: 7141248
    Abstract: Methods of producing an intraocular lens include introducing a solution into a lens forming enclosure, wherein the solution comprises discrete crosslinkable units of a size small enough to provide an optically clear solution while contributing to a high refractive index of at least 1.3, performing crosslinking between the units of the solution, and thereby forming a solid lens in the enclosure, optionally under a forming pressure.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: November 28, 2006
    Assignee: AMO Groningen BV
    Inventors: Kenneth A. Hodd, Keith Alfred Dillingham, Jacqueline de Groot
  • Dispersible macromolecule compositions and methods for their preparation and use
    Patent number: 7138141
    Abstract: A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: November 21, 2006
    Assignee: Nektar Therapeutics
    Inventors: Robert Platz, Thomas Brewer, Terrence Boardman
  • Liposome compositions of porphyrin photosensitizers
    Patent number: 7135193
    Abstract: Liposomal pharmaceutical formulations incorporating porphyrin photosensitizers useful for photodynamic therapy or diagnosis of malignant cells. The liposomal formulations comprise a porphyrin photosensitizer, particularly the hydro-mono benzoporphyrins (BPD) having light absorption maxima in the range of 670–780 nanometers, a disaccharide or polysaccharide and one or more phospholipids.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: November 14, 2006
    Assignee: QLT, Inc.
    Inventors: Narendra R. Desai, Bushra J. Agha, Kalidas Madhavrao Kale, James R. Lawter
  • Cationic lipid compositions targeting angiogenic endothelial cells
    Patent number: 7135192
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: November 14, 2006
    Assignee: The Regents of the University of California
    Inventors: Donald M. McDonald, John McLean, O. Gavin Thurston, Peter Baulk
  • Odorless formulation for treating mucosal discontinuities
    Patent number: 7132111
    Abstract: The present invention includes a method for making a formulation for treating mucosal discontinuities, comprising: providing phenolic compounds and treating the purified phenolic compounds with sulfuric acid to make sulfonic acids and sulfonate salts. The present invention also includes formulations prepared by the method.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: November 7, 2006
    Assignee: Epien Medical, Inc.
    Inventor: Michael Basara
  • Immunstimulating lipid formulation
    Patent number: 7128909
    Abstract: A pharmaceutical formulation for parenteral or mucosal administration of antigens and/or vaccines to humans and animals, comprising monoglyceride preparations having at least 80% monoglyceride content and where the acyl group contains from 6 to 24 carbon atoms, together with fatty acids where the number of carbon atoms may be varied between 4 and 22.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: October 31, 2006
    Assignee: Eurocine AB
    Inventor: Ulf Schröder
  • Compositions and methods for treating sexual dysfunction
    Patent number: 7128930
    Abstract: Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to the genitals of the patient. The methods allow for localized NO delivery through topical application of the present compounds, while minimizing, if not preventing, damage associated with peroxynitrite formation. Compositions comprising L-arginine, or a derivative thereof and an antioxidant in a pharmaceutical carrier suitable for application to the genitals is also disclosed.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: October 31, 2006
    Inventors: Meir S. Sacks, Knox Van Dyke
  • Lipophilic drug compositions
    Patent number: 7125568
    Abstract: The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active agent is both covalently attached to a lipid and encapsulated within a lipid composition. Preferred lipid components include triglycerides and fatty acids. The resulting composition is preferably adapted for oral administration.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: October 24, 2006
    Inventor: Michael T. Sung
  • Particulate drug-containing products and method of manufacture
    Patent number: 7125566
    Abstract: Provided is a compressed anti-solvent technique for manufacture of drug-containing powders for pulmonary delivery. The drug is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the manufacture method, including powders of substantially pure drug and powders including a biocompatible polymer for pulmonary sustained drug release applications. Also provided are packaged products including drug-containing powder in a container that is receivable by and operable with a dry powder inhaler to produce an aerosol including dispersed drug-containing particles when the inhaler is actuated.
    Type: Grant
    Filed: November 19, 2003
    Date of Patent: October 24, 2006
    Assignee: RxKinetix, Inc.
    Inventor: Jeffrey B. Etter
  • Therapeutic liposome composition and method of preparation
    Patent number: 7122202
    Abstract: Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: October 17, 2006
    Assignee: Alza Corporation
    Inventors: Theresa M. Allen, Paul Uster, Francis J. Martin, Samuel Zalipsky
  • Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
    Patent number: 7122203
    Abstract: The present invention is directed to pharmaceutical formulations containing 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxypheny)benzo[b]thiophene or a salt thereof; stabilized to oxidation or other forms of decomposition by incorporation of a stabilizing agent selected from methionine, acetylcysteine, cysteine or salts thereof.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: October 17, 2006
    Assignee: Eli Lilly and Company
    Inventors: Fadia Najjar Bashore, Kerry John Hartauer, Michael Dean Minnett, Eugene Clark Rickard, Cheryl Ann Tingle
  • Cationic liposome delivery of taxanes to angiogenic blood vessels
    Patent number: 7112338
    Abstract: Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: September 26, 2006
    Assignee: The Regents of the University of California
    Inventors: Donald M. McDonald, John W. McLean, O. Gavin Thurston
  • Liposome composition for delivery of nucleic acid
    Patent number: 7112337
    Abstract: A liposome composition for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a lipid that is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH and (ii) a lipid joined to a hydrophilic polymer by a dithiobenzyl linkage. The liposomes are associated with a nucleic acid for delivery to a cell.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: September 26, 2006
    Assignee: ALZA Corporation
    Inventors: Shi-Kun Huang, Samuel Zalipsky, Wei-Ming Zhang
  • Liposome compositions and methods for the treatment of atherosclerosis
    Patent number: 7101570
    Abstract: The present invention provides compositions and methods for treating atherosclerosis. The compositions comprise unilamellar liposomes having an average diameter of 100-150 nanometers. Methods for treating atherosclerosis employing the compositions of the present invention are also provided.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: September 5, 2006
    Assignee: The University of British Columbia
    Inventors: Michael J. Hope, Wendi Rodrigueza
  • Nanoparticulate megestrol formulations
    Patent number: 7101576
    Abstract: The present invention is directed to nanoparticulate compositions comprising megestrol. The megestrol particles of the composition have an effective average particle size of less than about 2000 nm.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: September 5, 2006
    Assignee: Elan Pharma International Limited
    Inventors: Douglas Hovey, John Pruitt, Tuula Ryde
  • Controlled release preparations having multi-layer structure
    Patent number: 7101567
    Abstract: Preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs can be precisely controlled, which consist of an outer layer wherein a water-soluble drug is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and one or more inner layers wherein a water-soluble drug, differing in kind or concentration from the one contained in the outer layer, is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and in which the outer and inner layers are concentrically located in diametral direction of rod-like preparations and both or one of the ends in the axial direction are opened so as to directly come into contact with the environment.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: September 5, 2006
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Akihiko Sano, Masako Kajihara, Toshihiko Sugie