Patents Examined by Gregg Polansky
  • Patent number: 10125150
    Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 13, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
  • Patent number: 10117882
    Abstract: Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: November 6, 2018
    Assignee: AKER BIOMARINE ANTARCTIC AS
    Inventors: Inge Bruheim, Mikko Griinari, Sebastiano Banni, Per Christian Saebo, Erik Fuglseth
  • Patent number: 10100309
    Abstract: The present invention relates to methods and compositions for treating and/or preventing allergic diseases or conditions by inhibiting one or more components of the steroidogenic pathway.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 16, 2018
    Assignee: National Jewish Health
    Inventors: Erwin W. Gelfand, Meiqin Wang, Yi Jia
  • Patent number: 10085971
    Abstract: A kit for treating psychosis by administering a pharmaceutically acceptable liquid composition of Asenapine to oral mucosa includes a formulation having Asenapine, or a pharmaceutically acceptable salt or hydrate thereof, ethanol, and water and a multidose pump filled with the formulation. The Asenapine compositions are stable for an extended period of time at normal storage conditions.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: October 2, 2018
    Assignee: Navinta III Inc
    Inventor: Mahendra R. Patel
  • Patent number: 10064836
    Abstract: Compositions and methods for treating parasitic infections are provided. The compositions can include two or more of alpha-pinene, linalyl acetate, para-cymene, and thymol octanoate. The compositions and methods can be effective against, for example, protozoan parasites, helminthic parasites, nematodes, trematodes, flukes, cestodes, and the like. Formulations made from the composition are also provided, including formulations in which the composition is combined with a carrier to form a food product and/or a drink. The formulation can be, for example, a suspension, a solution, or an emulsion in an oily or an aqueous carrier; likewise, the composition can be provided in an encapsulated or microencapsulated form.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: September 4, 2018
    Assignee: TyraTech, Inc.
    Inventors: Essam Enan, Ahmad Akashe, Anilkumar Gaonkar, Leslie West
  • Patent number: 10046054
    Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: August 14, 2018
    Assignee: Purdue Research Foundation
    Inventors: Philip S. Low, Sumith A. Kularatne
  • Patent number: 10039734
    Abstract: Provided herein are compositions comprising eicosapentaenoic acid (EPA) and polar lipids (e.g., glycolipids and phospholipids), and which do not contain any docosahexaenoic acid (DHA) or esterified fatty acids.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: August 7, 2018
    Assignee: Qualitas Health, Ltd.
    Inventors: Brian J. Waibel, Hans Schonemann, Val Krukonis, Michael Kagan
  • Patent number: 10034850
    Abstract: The present application relates to a pharmaceutical preparation comprising (a) from 0.15 to 3 weight percent of glyceryl trinitrate, (b) from 40 to 95 weight percent water, and (c1) from 2 to 10 weight percent of at least one water soluble polymer, or (c2) from 1 to 10 weight percent of at least one water soluble polymer and 5 to 20 weight percent of ethanol.
    Type: Grant
    Filed: November 28, 2014
    Date of Patent: July 31, 2018
    Assignee: G. POHL-BOSKAMP GMBH & CO. KG
    Inventors: Andreas Gerber, Michaela Gorath, Thomas Zimmeck
  • Patent number: 10028968
    Abstract: A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 24, 2018
    Assignee: AKER BIOMARINE ANTARCTIC AS
    Inventor: Fotini Sampalis
  • Patent number: 10016396
    Abstract: The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein the composition is formulated as a liquid for parenteral administration to a subject, and wherein the composition is disposed within a sealed container as a premixture. The pharmaceutical compositions can be used, for example, in perioperative care of a patient or for sedation.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 10, 2018
    Assignee: HOSPIRA, INC.
    Inventors: Priyanka Roychowdhury, Robert A. Cedergren
  • Patent number: 10010071
    Abstract: A liquid concentrate which includes: a) from 20 to 70% by weight of 3-phenylpropan-1-ol, b) from 10 to 50% by weight of 1,2-octanediol, c) from 15 to 60% by weight of 1,3-propanediol, and d) where necessary up to 2000 ppm of one or more antioxidants; and a composition for topical application, including such liquid concentrate.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: July 3, 2018
    Assignee: L'AIR LIQUIDE SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE
    Inventors: Carsten Bungenstock, Sarah Erichsen, Sabine Herweg, Sonja Luthje, Klaus Weber
  • Patent number: 9994515
    Abstract: The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: June 12, 2018
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sabyasachi Sanyal, Atul Kumar, Naibedya Chattopadhyay, Jawahar Lal, Arun Kumar Trivedi, Dipak Datta, Srikanta Kumar Rath, Tahseen Akhtar, Shailendra Kumar Dhar Dwivedi, Manisha Yadav, Bandana Chakravarti, Abhishek Kumar Singh, Jay Sharan Mishra, Nidhi Singh, Anil Kumar Tripathi
  • Patent number: 9988401
    Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino) ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: June 5, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
  • Patent number: 9974301
    Abstract: This invention relates to a fungicidal composition for controlling phytopathogenic diseases, comprising a mixture of volatile compounds: 14-17% v/v ethanol, 28-33% v/v 3-methylbutanol, 18-21% v/v isobutyl acetate, 17-20% v/v isoamyl acetate, and 13-16% v/v alpha-bisabolol, relative to the total volume of the composition. The invention also relates to the use of the fungicidal composition in order to inhibit the growth of the pathogenic fungus Botrytis cinerea.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: May 22, 2018
    Assignee: UNIVERSIDAD DE LA FRONTERA
    Inventors: Andres Quiroz, Heidi Schalchli, Emilio Hormazabal
  • Patent number: 9974768
    Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: May 22, 2018
    Assignee: Meiji Seika Pharma Co., Ltd.
    Inventors: Koichi Kitamura, Maho Kondo, Kiyoshi Shimoyama, Toru Kurosawa
  • Patent number: 9968571
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 15, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Robert D. Allen, III, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
  • Patent number: 9962343
    Abstract: A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously over a prolonged time period is disclosed. In certain embodiments, the dose is intravenously administered in a time period from about 10 minutes to about 3 hours, preferably from about 10 minutes to about 30 minutes. In other embodiments, intravenous doses are administered at suitable time intervals over a time period from about 3 hours to 48 hours.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: May 8, 2018
    Assignee: Revogenex Ireland Inc.
    Inventors: S. George Kottayil, Jeffrey H. Ping
  • Patent number: 9943499
    Abstract: The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor. It is based, at least in part, on the discoveries that lipotoxicity contributes to inflammation, multisystem organ failure, necrotic pancreatic acinar cell death and in acute pancreatitis, and that inhibition of lipolysis was able to reduce indices associated with these conditions. Accordingly, in various embodiments, the present invention provides for methods and compositions for limiting lipotoxicity and thereby reducing the likelihood of poor outcomes associated with acute pancreatitis and other severe systemic conditions, especially in obese individuals.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: April 17, 2018
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventor: Vijay Prem Singh
  • Patent number: 9896464
    Abstract: Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: February 20, 2018
    Assignee: Retrophin, Inc.
    Inventors: Andrew Vaino, Marek Biestek, Martin Shkreli
  • Patent number: 9867375
    Abstract: The present invention provides methods comprising applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein —B1—B2—B3— is —C?N—O—, —C?N—CH2—, —N—CH2—CH2—, or —C?C—O—; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group (X) wherein X2 is C—X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X6 is not hydrogen; A is selected from group (A1) to (A4) and Y1, Y2, Y3, R5 and R8 are as defined in claim 1. The methods are preferably for the control of stinkbugs, in particular Euschistus.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: January 16, 2018
    Assignee: Syngenta Participations AG
    Inventors: Myriem El Qacemi, Jerome Yves Cassayre