Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
Type:
Grant
Filed:
May 15, 2018
Date of Patent:
November 13, 2018
Assignee:
Incyte Corporation
Inventors:
Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
Abstract: Novel marine lipid compositions comprising triglycerides and omega-3 rich phospholipids are described. The compositions are characterized by providing highly bioavailable omega-3, increased tissue incorporation of omega-3 and reduced concentration of pro-inflammatory cytokines.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
November 6, 2018
Assignee:
AKER BIOMARINE ANTARCTIC AS
Inventors:
Inge Bruheim, Mikko Griinari, Sebastiano Banni, Per Christian Saebo, Erik Fuglseth
Abstract: The present invention relates to methods and compositions for treating and/or preventing allergic diseases or conditions by inhibiting one or more components of the steroidogenic pathway.
Abstract: A kit for treating psychosis by administering a pharmaceutically acceptable liquid composition of Asenapine to oral mucosa includes a formulation having Asenapine, or a pharmaceutically acceptable salt or hydrate thereof, ethanol, and water and a multidose pump filled with the formulation. The Asenapine compositions are stable for an extended period of time at normal storage conditions.
Abstract: Compositions and methods for treating parasitic infections are provided. The compositions can include two or more of alpha-pinene, linalyl acetate, para-cymene, and thymol octanoate. The compositions and methods can be effective against, for example, protozoan parasites, helminthic parasites, nematodes, trematodes, flukes, cestodes, and the like. Formulations made from the composition are also provided, including formulations in which the composition is combined with a carrier to form a food product and/or a drink. The formulation can be, for example, a suspension, a solution, or an emulsion in an oily or an aqueous carrier; likewise, the composition can be provided in an encapsulated or microencapsulated form.
Type:
Grant
Filed:
August 5, 2013
Date of Patent:
September 4, 2018
Assignee:
TyraTech, Inc.
Inventors:
Essam Enan, Ahmad Akashe, Anilkumar Gaonkar, Leslie West
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Abstract: Provided herein are compositions comprising eicosapentaenoic acid (EPA) and polar lipids (e.g., glycolipids and phospholipids), and which do not contain any docosahexaenoic acid (DHA) or esterified fatty acids.
Type:
Grant
Filed:
April 21, 2017
Date of Patent:
August 7, 2018
Assignee:
Qualitas Health, Ltd.
Inventors:
Brian J. Waibel, Hans Schonemann, Val Krukonis, Michael Kagan
Abstract: The present application relates to a pharmaceutical preparation comprising (a) from 0.15 to 3 weight percent of glyceryl trinitrate, (b) from 40 to 95 weight percent water, and (c1) from 2 to 10 weight percent of at least one water soluble polymer, or (c2) from 1 to 10 weight percent of at least one water soluble polymer and 5 to 20 weight percent of ethanol.
Type:
Grant
Filed:
November 28, 2014
Date of Patent:
July 31, 2018
Assignee:
G. POHL-BOSKAMP GMBH & CO. KG
Inventors:
Andreas Gerber, Michaela Gorath, Thomas Zimmeck
Abstract: A phospholipid extract from a marine or aquatic biomass possesses therapeutic properties. The phospholipid extract comprises a variety of phospholipids, fatty acid, metals and a novel flavonoid.
Abstract: The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein the composition is formulated as a liquid for parenteral administration to a subject, and wherein the composition is disposed within a sealed container as a premixture. The pharmaceutical compositions can be used, for example, in perioperative care of a patient or for sedation.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
July 10, 2018
Assignee:
HOSPIRA, INC.
Inventors:
Priyanka Roychowdhury, Robert A. Cedergren
Abstract: A liquid concentrate which includes: a) from 20 to 70% by weight of 3-phenylpropan-1-ol, b) from 10 to 50% by weight of 1,2-octanediol, c) from 15 to 60% by weight of 1,3-propanediol, and d) where necessary up to 2000 ppm of one or more antioxidants; and a composition for topical application, including such liquid concentrate.
Type:
Grant
Filed:
September 22, 2014
Date of Patent:
July 3, 2018
Assignee:
L'AIR LIQUIDE SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE
Inventors:
Carsten Bungenstock, Sarah Erichsen, Sabine Herweg, Sonja Luthje, Klaus Weber
Abstract: The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.
Type:
Grant
Filed:
August 29, 2014
Date of Patent:
June 12, 2018
Assignee:
Council of Scientific & Industrial Research
Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino) ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
Type:
Grant
Filed:
May 10, 2016
Date of Patent:
June 5, 2018
Assignee:
Incyte Corporation
Inventors:
Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
Abstract: This invention relates to a fungicidal composition for controlling phytopathogenic diseases, comprising a mixture of volatile compounds: 14-17% v/v ethanol, 28-33% v/v 3-methylbutanol, 18-21% v/v isobutyl acetate, 17-20% v/v isoamyl acetate, and 13-16% v/v alpha-bisabolol, relative to the total volume of the composition. The invention also relates to the use of the fungicidal composition in order to inhibit the growth of the pathogenic fungus Botrytis cinerea.
Type:
Grant
Filed:
December 31, 2013
Date of Patent:
May 22, 2018
Assignee:
UNIVERSIDAD DE LA FRONTERA
Inventors:
Andres Quiroz, Heidi Schalchli, Emilio Hormazabal
Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.
Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
Type:
Grant
Filed:
December 22, 2016
Date of Patent:
May 15, 2018
Assignee:
SIGA TECHNOLOGIES, INC.
Inventors:
Robert D. Allen, III, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
Abstract: A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously over a prolonged time period is disclosed. In certain embodiments, the dose is intravenously administered in a time period from about 10 minutes to about 3 hours, preferably from about 10 minutes to about 30 minutes. In other embodiments, intravenous doses are administered at suitable time intervals over a time period from about 3 hours to 48 hours.
Abstract: The present invention relates to methods for treating pancreatitis and/or organ failure comprising administering, to a subject in need of such treatment, an effective amount of a lipase inhibitor. It is based, at least in part, on the discoveries that lipotoxicity contributes to inflammation, multisystem organ failure, necrotic pancreatic acinar cell death and in acute pancreatitis, and that inhibition of lipolysis was able to reduce indices associated with these conditions. Accordingly, in various embodiments, the present invention provides for methods and compositions for limiting lipotoxicity and thereby reducing the likelihood of poor outcomes associated with acute pancreatitis and other severe systemic conditions, especially in obese individuals.
Type:
Grant
Filed:
April 2, 2015
Date of Patent:
April 17, 2018
Assignee:
University of Pittsburgh—of the Commonwealth System of Higher Education
Abstract: Compounds having the following formula (E): Formula E or a pharmaceutically acceptable salt thereof, wherein R, R?, R?, X and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided.
Type:
Grant
Filed:
October 27, 2014
Date of Patent:
February 20, 2018
Assignee:
Retrophin, Inc.
Inventors:
Andrew Vaino, Marek Biestek, Martin Shkreli
Abstract: The present invention provides methods comprising applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein —B1—B2—B3— is —C?N—O—, —C?N—CH2—, —N—CH2—CH2—, or —C?C—O—; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group (X) wherein X2 is C—X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X6 is not hydrogen; A is selected from group (A1) to (A4) and Y1, Y2, Y3, R5 and R8 are as defined in claim 1. The methods are preferably for the control of stinkbugs, in particular Euschistus.