Abstract: The present invention provides a method of inhibiting the formation of pseudorabies particles in a host cell. The method involves administering an effective amount of a poly-hydroxylated stilbene, particularly resveratrol, to a herpes virus infected host cell. The present invention also provides a method of reducing or inhibiting the growth of Neisseria gonorrhea and Neisseria meningiditis in vitro and in vivo. The method comprises administering a composition comprising a therapeutically effective amount of a tri-hydroxylated stilbene to a growth surface which has come into contact or could come into contact with the bacterium.
Type:
Grant
Filed:
December 11, 2001
Date of Patent:
May 2, 2006
Assignee:
Northeastern Ohio Universities College of Medicine
Abstract: The invention relates to a compound of the general formula (I) where R1, R2, R3, R4, R1?, R2?, R3? and R4? are independently of one another hydrogen, C1–C15-alkyl, C2–C15-alkenyl, C2–C15-alkinyl, C3–C16-cycloalkyl, C3–C16-cycloalkenyl, aryl or a heterocyclus which in each case can be substituted or unsubstituted, Y is a physiologically compatible anion, and n is 1 or 2, as well as its application to the prophylaxis and/or tretment of cancer illnesses.
Type:
Grant
Filed:
October 3, 2003
Date of Patent:
March 28, 2006
Assignee:
Faustus Forschungs Cie. Translational Cancer Research GmbH
Abstract: The invention provides compounds of formula I: wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, compositions, or salts to treat cancer. In embodiments, R4 and R5 taken together can be a 3, 4, or 5 membered saturated or unsaturated chain comprising members selected from the group consisting of non-peroxide oxygen, sulfur, N(X), and carbon, optionally substituted by oxo; wherein each X is independently absent or is H, O, (C1–C4)alkyl, phenyl or benzyl; and wherein at least one of the chain members is an N—H group.
Type:
Grant
Filed:
October 21, 2003
Date of Patent:
February 7, 2006
Assignee:
Rutgers, The State University of New Jersey
Inventors:
Edmond J. LaVoie, Jung Sun Kim, Leroy Fong Liu
Abstract: A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable reagent comprising a plurality of discrete particles, each of the particles comprising a plurality of layers of carbon and being capable of binding to fibrin; and detecting the presence of the particles in the source. The particles may also comprise a detectable marker encased in said plurality of layers of carbon, the presence of said marker being capable of detection in said source.
Type:
Grant
Filed:
July 23, 1998
Date of Patent:
December 20, 2005
Assignee:
The Australian National University
Inventors:
Chenicheri H. Nair, Elena A. Shats, William M. Burch, Rodney J. Browitt, Timothy J. Senden
Abstract: A high internal aqueous phase water-in-oil type emulsion cosmetic composition comprising a cross-linkable polyether-modified silicone in an amount of 0.1 to 10.0% by weight and a water-soluble polymer having a weight average molecular weight of 2000 to 300,000, an inorganic salt and an amino acid salt or a polyether-modified silicone, and having a content of an aqueous phase component of at least 50% by weight.