Abstract: Isolated DNAs which are DNAs having a base sequence represented by any of SEQ ID NOS: 1 to 6 in Sequence Listing or fragments thereof and showing a stationary phase-specific promoter activity in Gram-positive bacteria.

Abstract: The invention discloses the discovery of naturally occurring peptides that contain fatty acyl and prenyl moieties which permit the transfer of nucleotides, oligonucleotides, and polynucleotides into the cytoplasm and nucleus of cells. Their intrinsic properties cause them to tightly bind to nucleotides. This indicates that they might serve as nucleotide transporters. Experiments demonstrated that they permitted the transfer of nucleotides and polynucleotides into the cytoplasm and nucleus of cells. The peptides, due to their ability to transport ribonucleic acids into cells, can be employed in gene silencing by RNAi (ribonucleic acid interference) and antisense therapy. Among the ailments thought to benefit are: atherosclerosis by regulating cholesterol metabolism, cancer and similar diseases by delivering nucleic acids in chemotherapy. The peptides, due to their ability to transport ribonucleic acids into cells, can be employed in gene silencing.