Abstract: Pipe coupling usable for piping in pneumatic conditioning systems which has male and female assemblies each given in the form of a single united or single body and each provided with a valve assembly which can be incorporated into the associated assembly from the front side opening and set in prescribed position and posture without need for the conventionally employed swaging operations, and a valve closure body incorporated in the male assembly whose both fringes encroach upon corresponding surfaces formed on the male and female assemblies, respectively, in order to assure simplified preparation of the male and female assemblies, enhanced reliable fluid sealing effect even after a long use and release of assembly plants from the problem of chemical pollution of the environment.