Patents Examined by H. Sarah Park
  • Patent number: 10500300
    Abstract: A multi-layered wound care product includes an upper liquid-absorbing layer, an intermediate occlusive layer; and an active agent-releasing bottom layer. The latter two layers have common pores or perforations that enable the passage of wound exudate through the two layers to reach the liquid-absorbing layer. A use of the multi-layered wound care product for treatment of acute and chronic wounds and a method of producing the multi-layered wound care product are also provided.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 10, 2019
    Assignee: BSN Medical GmbH
    Inventors: Verena Dybe, Sascha Casu
  • Patent number: 10493027
    Abstract: A kit for mucosally administering a metastable supersaturated solution of a pharmaceutical active agent to a human patient includes a first compartment comprising a first composition comprising a pharmaceutical active agent in solution at or below equilibrium solubility, and a second composition comprising an acidic buffer. The first and second compartments maintain separation of the first and second compositions during storage, and allow for mixing of the first and second compositions to form a supersaturated solution above equilibrium solubility of the pharmaceutical active agent for immediate mucosal administration to a human patient. In one embodiment, the second composition comprises an acidic buffer and the supersaturated solution has an acidic pH. Alternatively, the second composition comprises a basic buffer and the supersaturated solution has a basic pH.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: December 3, 2019
    Inventor: Madhu Hariharan
  • Patent number: 10492947
    Abstract: A design for dynamically adjusting parameters applied to a surgical instrument, such as an ocular surgical instrument, is presented. The method includes detecting surgical events from image data collected by a surgical microscope focused on an ocular surgical procedure, establishing a desired response for each detected surgical event, delivering the desired response to the ocular surgical instrument as a set of software instructions, and altering the surgical procedure based on the desired response received as the set of software instructions.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: December 3, 2019
    Assignee: Johnson & Johnson Surgical Vision, Inc.
    Inventor: Michael J. Claus
  • Patent number: 10493099
    Abstract: A pharmaceutical composition is provided comprising a highly soluble arsenic carbonate and/or bicarbonate compound and which is useful in the treatment of a variety of cancers, including acute promyelocytic leukaemia. The arsenic carbonate and/or bicarbonate salt acts as a solid, and so orally deliverable, improved bioequivalent delivery form of arsenic trioxide IV solutions.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: December 3, 2019
    Assignee: EUPHARMA PTY LTD
    Inventor: Malvin Eutick
  • Patent number: 10441548
    Abstract: The present invention is a surface treated drug-loaded solid (e.g., non-porous) microparticle that aggregates in vivo to form a consolidated larger particle for medical therapy. In one embodiment, the particles are used for ocular therapy. Processes for producing the surface treated microparticle and injectable formulations which include the surface treated microparticle are also provided. When used in the eye, long-term consistent intraocular delivery can be achieved without disrupting vision and minimizing undesirable inflammatory responses.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: October 15, 2019
    Assignee: Graybug Vision, Inc.
    Inventors: Yun Yu, Joshua Kays, Ming Yang, Jeffrey L. Cleland
  • Patent number: 10413565
    Abstract: Nanostructures, compositions and methods for treating vesicle-related or exosome-related conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers, neurological disorders, rheumatologic disorders, viral disorders or other diseases or conditions at least in part by regulating vesicle uptake. Methods of analyzing, imaging and modulating vesicles and cellular vesicles processes are also provided.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: September 17, 2019
    Assignee: Northwestern University
    Inventors: Michael P. Plebanek, C. Shad Thaxton, Raja Kannan Mutharasan, Nicholas L. Angeloni, Kaylin M. McMahon
  • Patent number: 10391041
    Abstract: A sheet-like hair care product including (A) a substrate sheet containing cellulosic fibers and having a bending resistance of 10 to 70 mm measured by the 45° cantilever method in accordance with JIS L1096:2010 and (B) a liquid cosmetic composition. The substrate sheet (A) is impregnated with 1 to 50 g of the liquid cosmetic composition (B). The substrate sheet impregnated with the liquid cosmetic composition is preferably packaged in a packaging container having an access opening with an area of 25 to 4000 mm2 and an openable and closable lid sealing the contents.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: August 27, 2019
    Assignee: Kao Corporation
    Inventors: Eiichi Nishizawa, Azusa Kasuga, Keiko Ishii, Rina Iikubo, Kaori Kojima
  • Patent number: 10384046
    Abstract: Microstructure arrays and methods for using and manufacturing the arrays are described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Danir Bayramov, Guohua Chen, Zhongli Ding, Esi Ghartey-Tagoe, Parminder Singh, Doug Bourne
  • Patent number: 10383826
    Abstract: The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channel guides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: August 20, 2019
    Assignee: PROCAPS SA
    Inventors: Carlos Salazar Altamar, Gustavo Anaya, Braulio Teran, Newman Aguas Navarro, Wilmer Herrera
  • Patent number: 10285953
    Abstract: The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson's disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: May 14, 2019
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Nathan John Bryson, Anthony John Giovinazzo, Scott David Barnhart, Michael Clinton Koons
  • Patent number: 10278928
    Abstract: The present invention relates to a pharmaceutical composition for forming a film directly on a wound to accelerate wound healing, a use for the same, a treatment method using the same, and a method for preparing the same. The film-forming composition according to the present invention forms a film directly on the wound to increase the adhesion to the wound. The formed thin hydrophilic film protects the wound surface to prevent infection of the wound surface, retains the physiologically active substance useful for wound healing on the wound surface to promote the wound healing, and allow drugs to be continuously delivered to the wound surface. Therefore, the composition according to the present invention has excellent wound healing effect and has excellent usability as it is not absorbed into clothing, bandage, etc., thus effectively replacing conventional gel or ointment formations for delivering physiologically active substances.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 7, 2019
    Assignee: Dong-A Pharmaceutical Co., Ltd
    Inventors: Soon Hoe Kim, Mi Won Son, Sun Woo Jang, Joon Ho Jun, Sang Dug Han, Sung Rak Choi, Dae Hwan Kim, Yong Sung Sohn, Yong Sam Kwon
  • Patent number: 10258578
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 16, 2019
    Inventors: Frantz Le Dévédec, Christine Jane Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Patent number: 10231977
    Abstract: Described are transdermal drug delivery systems for the transdermal administration of levonorgestrel and ethinyl estradiol, comprising an acrylic polymer matrix. Methods of making and using such systems also are described.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: March 19, 2019
    Inventors: Prashant Patel, Viet Nguyen, Jun Liao
  • Patent number: 10206972
    Abstract: An anti-vascular diseases and antitumor pharmaceutical composition is provided in the present invention, and it includes effective ingredients including bleomycin antitumor antibiotic, adrenal glucocorticoid, epinephrine or pharmaceutically acceptable salts thereof in a weight ratio of (1-8):(2-5):(0.00005-0.001). The pharmaceutical composition provided can be used for treatment of vascular diseases and tumors.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: February 19, 2019
    Inventors: Hua Wang, Huanchun Liang
  • Patent number: 10201528
    Abstract: The invention provides methods for treating multiple sclerosis by administering biotin. The invention also provides methods for treating sequelae after multiple sclerosis attacks by administering biotin.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: February 12, 2019
    Assignee: Assistance Publique Hopitaux De Paris
    Inventor: Frédéric Sedel
  • Patent number: 10195308
    Abstract: Methods of preparing bioactive composites are described. Also described are methods of molding such composites. Shaped bodies comprising bioactive composites are further described.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: February 5, 2019
    Assignee: Orthovita, Inc.
    Inventors: James P. Murphy, Erik M. Erbe, Charanpreet S. Bagga, Marissa M. Conrad
  • Patent number: 10183077
    Abstract: An iron-based composition is described. The composition can be used in conditions of total or relative iron deficiency. In particular, a solid composition is described, preferably in the form of powder or granules, for use in the treatment of disorders or diseases related to or derived from an iron deficiency. The composition is suitable for pediatric subjects, adolescents, athletes, men, women, pregnant women and elderly. Finally, a process for preparing the solid composition is also described.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: January 22, 2019
    Assignee: ALESCO S.R.L.
    Inventors: Andrea Lacorte, Germano Tarantino
  • Patent number: 10159749
    Abstract: Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: December 25, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Jeremiah A. Johnson, Longyan Liao
  • Patent number: 10154972
    Abstract: Provided herein are methods for treating certain conditions, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a biguanide or related heterocyclic compound, e.g., metformin. Also provided herein are biguanide or related heterocyclic compound compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: December 18, 2018
    Inventors: Alain D. Baron, Mark S. Fineman, Nigel R. A. Beeley
  • Patent number: 10137128
    Abstract: The present invention relates generally to the field of using udenafil or a pharmaceutically acceptable salt thereof in patients who have undergone the Fontan operation.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: November 27, 2018
    Assignees: Mezzion Pharma Co., Ltd., The Children's Hospital of Philadelphia
    Inventors: James L. Yeager, David J. Goldberg, Stephen M. Paridon