Abstract: Long chain fatty acid amides of styryl hexahydroindolinols in which the amido portions have ethyleneically unsaturated positions or cyclopropanyl rings, eg 1-(1-oxo-9-cis-octadecenyl)-(3aRS, 4RS, 7aRS)-4-(Z)-(3,4-dimethoxy)-styryl-hexahydro-4-indolinol, are useful as cholesterol ester-reducing agents and are obtainable by reacting corresponding long chain carboxylic acids (or derivatives thereof) with appropriate 4-styryl-4-hexahydroindolinols.
Abstract: Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 2-indanamine compounds having 4 and/or 5 substituents.
Type:
Grant
Filed:
April 10, 1978
Date of Patent:
March 11, 1980
Assignee:
SmithKline Corporation
Inventors:
William E. Bondinell, Robert G. Pendleton
Abstract: An instillation composition, comprising an effective amount of at least one sparingly soluble active material suspended or partly dissolved in an aqueous emulsion containing a swelling agent. Advantageously the active substance is nitrofurantoin or a quinolone or pyridazine derivative, the active material has a particle size less than about 10 .mu.m and the swelling agent is a polysaccharide derivative present in about 0.3 to 3% by weight of the composition, the composition further containing at least one local anesthetic, antiphlogistic substance, emulsifier, buffer or stabilizer. With the invention, unit doses of only 50 ml. will contain sufficient active material.
Type:
Grant
Filed:
February 24, 1978
Date of Patent:
March 4, 1980
Assignee:
Boehringer Mannheim GmbH
Inventors:
Heinrich Woog, Werner Rothe, Werner Gruber
Abstract: Bromhexine derivatives corresponding to the following general formula ##STR1## and antitussive compositions therefrom, as well as a process for making same are described.
Abstract: A method of making a water-in-oil waterproof makeup comprising (a) a cosmetic emulsion oil, (b) a cosmetic pigment, and (c) an emulsifier combination comprising (i) a stearate and (ii) a polyhydric alcohol ester of a liquid fatty acid, and compositions therefrom.
Abstract: There is disclosed a pharmaceutical composition useful in stimulating blood circulation and healing of wounds. This composition comprises (a) albumin-freed calf blood extract, and (b) from about 0.001 to about 2.5 micrograms of at least one kinin per milligram of dry extracted substance. A method for treating patients in order to stimulate their blood circulation is also disclosed. This method comprises treating these patients with an effective amount of the pharmaceutical composition described above.
Type:
Grant
Filed:
December 30, 1977
Date of Patent:
December 4, 1979
Assignee:
Thera Gesellschaft fur Patentverwertung mbH
Abstract: A method of controlling mosquitos by adsorbing onto the surface of a body of water suitable for breeding mosquitos a monomolcular or duplex film of an organic material which reduces the surface tension of the body of water to 30 dynes/cm or less.
Type:
Grant
Filed:
January 31, 1977
Date of Patent:
July 3, 1979
Assignee:
The United States of America as represented by the Secretary of the Navy
Abstract: The present invention provides novel fungicidal compositions for agricultural use which comprise an effective amount of a 1-(alkoxyphenyl)-5-(phenyl)biguanide compound having the formula: ##STR1## where R is alkyl, linear or branched, having from 1-14 carbon atoms; and also acid addition salts thereof, in a suitable inert carrier material.The invention further relates to a method for controlling or protecting pathogenic fungi with a fungicidally effective amount of said compound. Fruit trees, especially apple trees, are controlled against the fungi which causes apple scab.
Type:
Grant
Filed:
May 1, 1978
Date of Patent:
January 30, 1979
Assignee:
GAF Corporation
Inventors:
Michael J. Brown, Bruce M. Resnick, James H. R. Woodland
Abstract: A composition of matter is described herein which has insecticidal and miticidal activity and methods of use. The composition may be defined by the following generic formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently methyl or halogen, preferably methyl or chlorine.