Abstract: Apparatus and systems are disclosed that incorporate coupling mechanisms to enable coupling of two mating member such as medical devices such as introducers, sheaths, dilators. More specifically, the disclosure relates to releasable coupling mechanisms, to allow for releasable coupling of two medical devices such as a dilator and a sheath so the devices can be maneuvered and/or manipulated together for example during a part of a medical procedure.

Abstract: Method, device, system and associated processing logic for providing optimal perioperative nociception management to anesthetized patient, including monitoring a plurality of nociception-related physiological parameters of the patient using at least two non-invasive physiological sensors; combining the plurality of nociception-related physiological parameters into a nociception index value indicative of a level of nociception of the patient, by applying a machine learning algorithm on the plurality of nociception-related physiological parameters and/or features derived therefrom; comparing the nociception index value to a first threshold value indicative of an upper limit of nociceptive-anti-nociceptive balance (NANB) and to a second threshold value indicative of a lower limit of NANB; and providing a treatment or treatment recommendation based on the comparison and on a clinical concern.

Abstract: The present disclosure relates to drug-delivery apparatuses, and in particular, to a drug-delivery apparatus with a fluidic subsystem that can be used to deliver multiple injections to a patient from a drug container storing a drug fluid. The fluidic subsystem may include multiple injection-needle compartments and re-sealable septa to allow multiple accesses to the drug container, while also preserving the sterility of the drug fluid and of the fluid pathway through which the fluid is delivered to a patient. In some embodiments, the fluidic subsystem may be used to deliver drug fluids that do not contain any preservatives (e.g., non-preserved drugs).

Abstract: An extension set may include a tube having an outer surface. An instrument, such as a tubing or a probe, may be disposed within the tube and may include a proximal end and a distal end. A translation handle may be coupled to the outer surface of the tube and may move along the outer surface between a proximal position and a distal position to translate the distal end of the instrument between a retracted position and an advanced position. In the advanced position, the distal end of the instrument may extend beyond the distal end of the tube and into a catheter assembly and/or vasculature of a patient.

Abstract: A robotic surgical tool includes a handle and an elongate shaft extendable through the handle and including an outer proximal tube and an inner spline rotatably received within the outer proximal tube. A first actuation system is housed within the handle and operable to rotate the inner spline relative to the outer proximal tube and thereby transfer torque to a proximal or distal end of the shaft. A second actuation system is housed within the handle and operable to drive the outer proximal tube and thereby advance or retract the elongate shaft in z-axis translation through the handle.

Abstract: A device for delivering a medical fluid (4) comprising a body which houses: at least one containment tank (20) of a medical fluid, a fluid injection device (24) which interfaces with said containment tank (20) and is suitable to allow controlled delivery of a fluid through a cannula (32), an extraction device (40) of the cannula (32) from a retracted or rest configuration to an extracted or infusion configuration, activation means (44) which comprise a rotor (48), rotatable about a rotation axis (X-X) in an injection rotation direction (I) and in a control rotation direction (C), opposite each other.

Abstract: This disclosure describes microfabricated intravascular devices that are configured for high axial strength while also maintaining effective bending flexibility. A tube member includes a series of circumferentially extending rings connected to one another by a series of axially extending beams. Transverse cuts separate and define the rings. A series of axial cuts are aligned with the beams and extend from the beams partially into the adjoining rings so that the beam length is nested partially within the axial length of the adjoining rings. This increases the functional length of the beams to provide bending flexibility while still sufficient ring structure to provide effective axial stiffness.

Abstract: The present invention is related to the field of devices for introducing and extracting media from the body, more specifically to the devices for introducing media into the body by means of intravascular access, and in particular, provides a puncture device for accessing the vascular system comprised of: a needle having a tubular body, with said tubular body having a distal end and a proximal end, a cutting edge in the distal end of said tubular body, and an expansion of the external diameter having a bulb shape next, in distal-proximal direction, to said cutting edge. In this way, a puncture device is provided for accessing the vascular system that solves the problem of allowing the echograph monitoring of the needle, but whose fabrication implies a reduction in the technical difficulty for its obtention, while it avoids the accidental perforation of the distal wall of the vessel of interest.

Abstract: Disclosed herein is a catheter placement system with a stiffening system and associated methods thereof. The catheter placement system can include a needle, catheter (e.g. rapid insertion central catheter), one or more guidewires, and a stiffening system, configured to place the catheter while containing portions of the catheter placement system that contact the patient within a sterile environment. Advantageously, the catheter placement system can provide all tools necessary for accessing a vasculature, dilating the insertion site and placing the catheter within a single device, mitigating repeated insertion of multiple tools and reducing the risk of introducing pathogens or the like. Further, the overall time required to place the catheter is reduced, reducing patient down time and improving patient outcomes.

Abstract: A medical device may include: a shaft configured to be inserted into a body lumen of a subject; a handle at a proximal end of the shaft, the handle including an adjustment mechanism configured to be transitioned from a first configuration, in which the shaft has a first stiffness, to a second configuration, in which the shaft has a second stiffness. The first stiffness may be different from the second stiffness.

Abstract: A device having a bone screw with a body, an outer thread and a proximal screw head. A fluid-permeable conduit is disposed in the body, begins at the head and opens out into a fluid outlet opening that is spaced apart from the head in the distal direction. An axial groove extends from the fluid outlet opening to the screw head. The base of the groove is deeper than the base of the outer thread. A cap detachably connects with the screw head, in which a fluid-permeable conduit is disposed, which opens out into the conduit of the bone screw. A hose for feeding fluid is connected or connectable in a fluid-permeable manner with the inlet opening on the cap so that a pharmaceutical fluid is pressable out of the fluid outlet opening through the hose, through the conduit of the cap and through the conduit of the bone screw.

Abstract: A communication device arranged for transmitting information from a medicament delivery device is presented. The communication device includes at least one translation detection arrangement, configured to detect a translation of at least one physical part of the medicament delivery device by utilization of a resilience and an electrical conductivity for at least one spring of the medicament delivery device. The communication device also includes at least one change of state detection unit, configured to detect at least one change of state for the medicament delivery device based on the detected translation. The communication device further includes at least one activation unit, configured to activate the at least one change of state detection unit based on the at least one detected translation. The communication device also includes at least one transmission unit configured to provide a wireless transmission of information related to the at least one change of state to an external receiving device.

Abstract: The invention provides a medical instrument with angle adjustment device, including a guidewire output portion, a guidewire guide portion, an adjustment control portion and traction wires. The guidewire output portion is bendable relative to the guidewire guide portion. The guidewire output portion is provided with a guidewire output hole. One end of each traction wire is connected to a proximal end of the guidewire output portion, and the other end of the traction wire is connected to a bending control member of the adjustment control portion. The adjustment control portion controls a bending angle of the guidewire output portion through the traction wire. The ends of the plurality of traction wires are evenly distributed along the guidewire output portion. The positions and quantity of traction wires are set to enable a medical instrument having a distal end with an adjustable bending degree to adjust angles in various directions as required.

Abstract: An injector comprising an outer housing, a generally longitudinally extending keyway formed in the outer housing, an inner housing located interiorly of the outer housing, a guide member mounted at one end of the inner housing, the guide member having at least one protrusion adapted to engage the keyway, a spring member, the spring member having a first end abutting the outer housing, a second end of the spring member abutting the guide member, a syringe mounted interiorly of the inner housing, a needle mounted on one end of the syringe, the syringe having a plunger and a plunger rod, a finger rest member mounted over the outer housing, the finger rest member being opaque to thereby prevent visual access to the keyway.

Abstract: The present disclosure relates to a drive subassembly for a drug delivery device, the drive subassembly comprising a housing and a plunger, wherein the plunger is adapted to be rotated between a locked position, in which the plunger is prevented from advancing, and a released position, in which the plunger is advancable, wherein at least one restraining component is provided to restrain rotation of the plunger from the locked position towards the released position.

Abstract: A system for delivery of molecular hydrogen (H2) into a bodily orifice of a subject, such as the vagina or anus/rectum, to provide therapeutic effect.

Abstract: A drug supply device includes: a tube body; a first expansion member configured to be expanded to a first outer diameter and a second expansion member configured to be expanded to a second outer diameter that is greater than the first outer diameter, the first expansion member and the second expansion member being positioned on a distal-end side of the tube body; and a masking member that extends between the expansion members and that is connected to outer surfaces of the expansion members at two ends thereof. The tube body includes an outlet that opens between the expansion members and a channel that is in communication with the outlet, the masking member is formed in an arc shape in a lateral cross-section that is orthogonal to the longitudinal axis, and the masking member stretches between the expansion members in a state in which the expansion members are expanded.

Abstract: The present invention is directed to an apparatus suitable for separating and collecting gas bubbles entrained in a liquid, wherein the apparatus comprises a housing defining at least one chamber, the chamber having an inlet port and an outlet port; a diverter positioned between the inlet port and the outlet port; and, an elongated exit tube with an intake end and an export end; wherein the intake end of the elongated exit tube is centrally located within the chamber and the export end of the elongated exit tube is connected to the outlet port of the chamber.

Abstract: A safety mechanism is disclosed configured for shielding a distal tip of an elongate medical device. The safety mechanism includes a sheath having a body defining a lumen extending axially and including a shroud extending axially and having one or more sheath apertures disposed therethrough. The safety mechanism further includes a clip, comprising one or more arms, each including a tab, a plate, and a grip, the tab including a keyhole aperture. The first arm and the second arm configured to transition between a first configuration and a second configuration, and an elongate biasing member extending from the first arm to the second arm and configured to bias the first arm and the second arm towards the second configuration. Transitioning from the first configuration to the second configuration disengages the sheath from a needle hub and engages the sheath with a tip of the elongate medical device.

Abstract: An apparatus for use with an access port implanted in a living body includes a locator assembly. The locator assembly includes at least one port sensor configured to sense an aspect of the access port, at least one skin sensor configured to sense a proximity of the apparatus to a skin of the living body, and a controller configured to determine a location of the access port based on the aspect sensed by the at least one port sensor, where the controller instructs the at least one port sensor to sense the aspect based on the proximity of the apparatus to the skin as sensed by the at least one skin sensor. The locator assembly also includes an output device configured to provide user feedback, and the controller is further configured to instruct the output device to provide the feedback based on the determined location of the access port.