Abstract: Constructs consisting of antigen-based heteropolymers (AHP's) are provided. The antigen-based heteropolymers comprise at least one monoclonal antibody specific for binding to complement receptor (CR1) site on a human or non-human primate erythrocyte, and the anti-CR1 monoclonal antibody is crosslinked to an antigen specific for a target pathogenic autoantibody. Further provided is a method for treating autoimmune diseases in human or non-human primates using the AHP.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
March 9, 1999
Assignee:
University of Virginia Alumni Patents Foundation
Inventors:
Ronald P. Taylor, Polly J. Ferguson, Edward N. Martin, Jr., William M. Sutherland, Craig J. Reist, Kirsten Greene, Cyd Johnson