Patents Examined by Harry J. Guttam
  • Vivo induction for enhanced function of isolated hepatocytes
    Patent number: 6394812
    Abstract: The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: May 28, 2002
    Assignee: Organogenesis Inc.
    Inventors: Susan J. Sullivan, Paul G. Gregory, Paul A. DiMilla