Patents Examined by Helen S. Sneed
  • Patent number: 5023252
    Abstract: The rate of absorption of drugs across skin and other body membranes such as mucous membranes and the blood brain barrier is enhanced by adding to the drug composition a compound which enhances the rate. This compound may be macrocyclic ester, diester, amide, diamide, amidine, diamidine, thioester, dithioester, thioamide, ketone or lactone. The macrocyclic ketone contains at least 12 carbon atoms.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: June 11, 1991
    Assignee: Conrex Pharmaceutical Corporation
    Inventor: Dean Hseih
  • Patent number: 4595753
    Abstract: Compositions of matter are disclosed which are highly useful in hydroformylation processes. The compositions are non-charged, non-chelated bis- and tris-(alkyl diaryl phosphine) rhodium carbonyl hydrides. The substituents of the alkyl group include heteroorganic radicals containing silane, silicone, ether, ester, keto and hydroxy oxygen, phosphine oxide and phosphorus ester phosphorus, amine, amide, amine oxide and heterocyclic nitrogen groups.These compositions are highly stable and selective catalysts for the hydroformylation of olefins under certain conditions. The disclosed catalyst systems contain a large excess of phosphine ligand and employ alpha-olefin plus synthesis gas reactant mixtures having a high H.sub.2 /CO ratio at relatively low pressures. They produce mostly aldehydes derived from terminal attack on the alpha-olefin reactant.
    Type: Grant
    Filed: November 30, 1983
    Date of Patent: June 17, 1986
    Assignee: Exxon Research and Engineering Co.
    Inventors: Alexis A. Oswald, Torris G. Jermasen, Andrew A. Westner, I-der Huang