Patents Examined by Henry R. Jiles
  • Patent number: 4726834
    Abstract: Herbicidally active novel benzodisultams of the formula ##STR1## in which R.sup.1 represents an optionally substituted radical from the series comprising alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aralkyl and aryl,R.sup.2 represents hydrogen, fluorine, chlorine, bromine, hydroxyl, cyclopropyl, C.sub.1 -C.sub.4 -alkyl (which is optionally substituted by fluorine and/or chlorine), C.sub.1 -C.sub.4 -alkoxy [which is optionally substituted by fluorine and/or chlorine], C.sub.1 -C.sub.4 -alkylthio (which is optionally substituted by fluorine and/or chlorine), amino, or C.sub.1 -C.sub.4 -alkyl- or di-(C.sub.1 -C.sub.4 -alkyl)-amino (which is optionally substituted by fluorine) andR.sup.3 represents hydrogen, fluorine, chlorine, bromine, hydroxyl, cyclopropyl, C.sub.1 -C.sub.4 -alkyl (which is optionally substituted by fluorine and/or chlorine), C.sub.1 -C.sub.4 -alkoxy (which is optionally substituted by fluorine and/or chlorine), C.sub.1 -C.sub.
    Type: Grant
    Filed: July 24, 1986
    Date of Patent: February 23, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Uwe Priesnitz, Hans-Jochem Riebel, Wolfgang Roy, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4727103
    Abstract: Isocyanurate esters of carboxyalkylthioalkanoesterphenols useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reacting an appropriate isocyanurate trithiol, which is a selected tris-mercapto alkanoic acid ester of tris-(2-hydroxyethyl) isocyanurate with an appropriate alkenyl compound, which is a selected 4-hydroxy-(mono- or di-alkyl)phenyl alkyl alkenoate. In a preferred embodiment, the ester is 1,3,5-tris [( 3,5-di-tert-butyl-4-hydroxyphenyl)-(3-propyl) oxycarbonylethylthiopropionyloxyethyl] isocyanurate.
    Type: Grant
    Filed: June 29, 1987
    Date of Patent: February 23, 1988
    Assignee: Mallinckrodt, Inc.
    Inventor: Neil Dunski
  • Patent number: 4727076
    Abstract: The invention provides tetrahydroquinolinylalkylamino pyrimidones, and ring homologues thereof, of the general formula (1): ##STR1## wherein R.sup.1 is hydrogen or an alkyl, alkoxy, halogen or amino-substituent, m and n are each 2, 3 or 4 and R.sup.2 is hydrogen, alkyl or variously substituted benzyl.The compounds are useful as histamine-H.sub.1 -receptor antagonists.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: February 23, 1988
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: David G. Cooper, George S. Sach
  • Patent number: 4727066
    Abstract: The preparation of esters of 1,4-dihydropyridine, useful in the prevention and treatment of cardiovascular disorders such as atheroma, of the formula ##STR1## wherein X is a phenyl moiety and Y is piperazine, piperidine or an amide of a benzenecarboxylic acid, is described.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: February 23, 1988
    Assignee: Cermol S.A.
    Inventors: Carlos E. Sunkel, Miguel Fau de Casa-Juana, Peter R. Statkow, Danielle Straumann
  • Patent number: 4723018
    Abstract: 2-phenylpyridine derivatives having the general formula: ##STR1## wherein Y is ##STR2## and Z is a straight chain alkyl group having from 1 to 16 carbon atoms, ##STR3## R' is a straight chain alkyl group having from 2 to 12 carbon atoms, R.sup.2 is a straight chain alkyl group having from 1 to 12 carbon atoms, n is an integer from 1 to 10 and * is an asymmetric carbon are provided. The derivatives are stable, have low viscosity, excellent electro-optical response properties and broaden the ferroelectric temperature range when added to ferroelectric liquid crystal compositions.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: February 2, 1988
    Assignee: Seiko Epson Corporation
    Inventors: Yoshio Shionozaki, Hiroshi Mukai, Tsuyoshi Obikawa, Shuhei Yamada, Rei Miyazaki
  • Patent number: 4722927
    Abstract: Certain disubstituted pyrimidineamides of oleic and linoleic acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: February 2, 1988
    Assignee: Warner-Lambert Company
    Inventor: Ann Holmes
  • Patent number: 4722931
    Abstract: The invention concerns a compound of the formula ##STR1## and salts thereof resulting from addition with pharmaceutically acceptable mineral or organic acid, wherein R is an alkylenedioxy group substituted at the 2',3'-position, and R.sub.1 and R.sub.2 are selected from the group consisting of a linear or branched alkyl having 1-4 carbon atoms, a methoxyethyl, or a 2-pyridyl methyl group. The compounds of the present invention are useful in relaxing cardiac or smooth muscle.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: February 2, 1988
    Assignee: Laboratorios Delagrange
    Inventors: Maria J. Verde Casanova, Joaquin A. Galiano Ramos
  • Patent number: 4722749
    Abstract: Substituted 2-pyridinesulfonamide 1-oxides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.
    Type: Grant
    Filed: December 5, 1986
    Date of Patent: February 2, 1988
    Assignee: Sandoz Ltd.
    Inventor: Shy-Fuh Lee
  • Patent number: 4723011
    Abstract: Pyridine-2,3-dicarboxylates of Formula I ##STR1## are prepared by reacting an alpha halo-beta keto ester of formula II ##STR2## with an alpha, beta-unsaturated aldehyde or ketone of formula III ##STR3## in the presence of a minimum of 2 molar equivalents of ammonium salt.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: February 2, 1988
    Assignee: American Cyanamid Company
    Inventor: Robert F. Doehner, Jr.
  • Patent number: 4723017
    Abstract: 3-Hydroxy-3-(2-methyl-5-pyridyl)-propionic acid alkyl esters which, as intermediate products that can be industrially produced in a simple manner, can be used for the production of 2-methylpyridine-5-propionic acid alkyl ester.
    Type: Grant
    Filed: December 24, 1986
    Date of Patent: February 2, 1988
    Assignee: Lonza Ltd.
    Inventor: James I. Grayson
  • Patent number: 4723022
    Abstract: A new class of substituted 2,3-naphthalenedicarboxaldehydes (NDA) is disclosed. Such compounds are of the formula: ##STR1## wherein one or more of R.sub.1 -R.sub.8 are various substituting groups. The above compounds react, in the presence of cyanide ion, with compounds containing primary amino groups to form adducts which exhibit a high fluorescent yield and thus are readily detected and measured by fluorometric assaying techniques.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: February 2, 1988
    Assignee: Oread Laboratories, Inc.
    Inventors: Richard S. Givens, Robert G. Carlson, Kasturi Srinivasachar, Takeru Higuchi, Osborne S. Wong, Takeru Higuchi
  • Patent number: 4721785
    Abstract: A compound of the formula ##STR1## in which Q is N or CH,M.sup.1 is hydrogen, C.sub.1 -C.sub.6 -alkyl (which is optionally substituted by fluorine, chlorine or cyano), C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkinyl or benzyl in particular hydrogen,R.sup.37 is hydrogen or C.sub.1 -C.sub.4 -alkoxy, andR.sup.39 is C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy.The compounds are intermediates in the preparation of new herbicides.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: January 26, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Koichi Moriya, Theodor Pfister, Hans-Jochem Riebel, Ludwig Eue, Robert R. Schmidt, Klaus Lurssen
  • Patent number: 4721718
    Abstract: This invention relates to 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.
    Type: Grant
    Filed: August 18, 1986
    Date of Patent: January 26, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Gilbert W. Adelstein, Alan E. Moormann, Chung-Hwai Yen
  • Patent number: 4721782
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: January 26, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventor: Fritz Maurer
  • Patent number: 4721719
    Abstract: Reducing blood sugar with the novel dihydropyridinelactols, or salts thereof, of the formula ##STR1## in which R.sup.1 represents a phenyl, naphthyl, thienyl, pyridyl, chromonyl, thiochromonyl or thiochromenyl radical, the stated radicals optionally containing 1 or 2 identical or different substituents from the group consisting of fluorine, chlorine and bromine, alkyl, alkoxy and alkylthio, each having 1 to 6 carbon atoms, and fluoroalkyl or fluoroalkoxy, each having up to 3 carbon atoms and 3 fluorine atoms, and nitro and cyano,R.sup.2 represents a straight-chain, branched or cyclic alkyl having up to 12 carbon atoms which is optionally interrupted by 1 or 2 oxygen or sulphur atoms and which is optionally substituted by fluorine, chlorine, phenyl, cyano, hydroxyl, amino, C.sub.1 -C.sub.3 -alkylamino, di-C.sub.1 -C.sub.3 -alkylamino or N-benzylmethylamino,R.sup.3 represents cyano or straight-chain or branched alkyl which has up to 4 carbon atoms and is optionally interrupted in the chain by N-C.sub.1 -C.sub.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: January 26, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Siegfried Goldmann, Friedrich Bossert, Hans J. Ahr, Hilmar Bischoff, Walter Puls, Dieter Petzinna, Klaus Schlossmann, Joachim Bender
  • Patent number: 4721717
    Abstract: The present invention provides aminoalcohols of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be same or different, are hydrogen atoms, hydroxyl groups, C.sub.1 -C.sub.4 -alkoxy, benzyloxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.1 -C.sub.4 -alkanesulphonylamino, C.sub.1 -C.sub.4 -alkanesulphinyl or C.sub.1 -C.sub.4 -alkanesulphonyl radicals, m is 2, 3 or 4, X and Y, which can be the same or different, are hydrogen atoms or benzyl radicals and R.sub.3 is a phenyl radical substituted twice by C.sub.1 -C.sub.6 -alkyl radicals, a nitrophenyl radical, an aminophenyl radical, a 1,3,5-tri-C.sub.1 -C.sub.6 -alkyl-2,4-dioxo-1H,3H-pyrimidin-6-yl radical, an indolyl radical, an indazolyl radical, a benzimidazolyl radical, a 1,4-di-C.sub.1 -C.sub.6 -alkylpyrazol-5-yl radical or a radical of the general formula: ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different, are C.sub.1 -C.sub.4 -alkyl radicals and R.sub.6 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: January 26, 1988
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Wolfgang Kampe, Erwin Bohm, Klaus Strein
  • Patent number: 4721789
    Abstract: A process for making 3-cyanopyridine by the vapor phase catalytic reaction of 2-methylglutaronitrile with molecular oxygen.
    Type: Grant
    Filed: December 5, 1984
    Date of Patent: January 26, 1988
    Assignee: The Standard Oil Company
    Inventors: Robert DiCosimo, James D. Burrington, Robert K. Grasselli
  • Patent number: 4721708
    Abstract: Novel N-substituted tetrahydropyridine compounds are disclosed. The compounds have the property of inhibiting calcium induced contraction of smooth muscle and are adaptable to being employed in the chemotherapeutic treatment of cardiovascular diseases.
    Type: Grant
    Filed: November 26, 1985
    Date of Patent: January 26, 1988
    Assignee: Merck & Co., Inc.
    Inventors: George D. Hartman, Brian T. Phillips
  • Patent number: 4721794
    Abstract: Thiophene-2-sulfonamides with a 5-alkyl-S(O).sub.n -substituent are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: January 26, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, Samuel L. Graham
  • Patent number: 4721522
    Abstract: Novel pyridine compounds of formula I below have good selective herbicidal properties pre- and postemergence and also influence or inhibit plant growth. The compounds are of formula I ##STR1## wherein each of X, Y and Z independently of one another is hydrogen or a C.sub.1 -C.sub.4 alkyl group, or two adjacent substituents together also form a saturated or unsaturated 3- or 4-membered alkylene chain or alkenyl chain, each of which chains may in turn by substituted by one to four C.sub.1 -C.sub.4 alkyl groups, R is the hydroxyamino group, a C.sub.1 -C.sub.4 alkoxyamino, C.sub.3 -C.sub.4 alkenyloxyamino or C.sub.3 -C.sub.4 alkynyloxyamino group, a --PO(C.sub.1 -C.sub.4 alkyl).sub.2 or --PO(CH.sub.3)OC.sub.1 -C.sub.4 alkyl radical or an unsubstituted or substituted hydrazino radical.
    Type: Grant
    Filed: November 3, 1986
    Date of Patent: January 26, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Dieter Durr, Hans-Georg Brunner, Henry Szczepanski