Patents Examined by Hieu Phan
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Patent number: 6626941Abstract: Prosthetic implants designed to be implanted in the cornea for modifying the cornea curvature and altering the corneal refractive power for correcting myopia, and myopia with astigmatism, such implants formed of a micro-porous hydrogel material.Type: GrantFiled: October 19, 2001Date of Patent: September 30, 2003Assignee: Anamed, Inc.Inventor: Alok Nigam
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Patent number: 6626945Abstract: A cartilage plug, which is made from a biocompatible, artificial material, that is used to fill a void in natural cartilage that has been resected due to traumatic injury or chronic disease. Alternatively, the plug may be relied upon to anchor a flowable polymer to subchondral bone. The plug is prefabricatable in any size, shape, and contour and may be utilized either singly or in a plurality to fill any size void for any application. The plug may be formed of a laminated structure to match the physiological requirements of the repair site. A plurality of anchoring elements may share a single upper layer.Type: GrantFiled: February 28, 2001Date of Patent: September 30, 2003Assignee: ChondroSite, LLCInventors: Timothy Simon, Harold M. Aberman, Douglas W. Jackson
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Patent number: 6623522Abstract: A bio-compatible corneal ring for myopic correction and accommodation for presbyopia. The corneal ring is made from a bio-compatible material with a lens body having an inner and outer circular edge. The inner circular edge forms an opening in the lens body. The posterior surface of the lens body has a uniform radii of curvature between the inner and outer circular edges. The anterior surface has two radii of curvatures providing for correction of myopia. The first radii of curvature extends from near the outer circular edge to a junction point before the inner circular edge. The second radii of curvature extends from the junction point and continues to the inner circular edge. The inner and outer circular edges have a thickness of less than about 0.020 mm, but preferably are about 0.010 mm or less.Type: GrantFiled: November 7, 2001Date of Patent: September 23, 2003Inventor: Alok Nigam
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Patent number: 6620203Abstract: The present invention provides a tissue engineered testicular prosthesis for implanting within a patient having a scaffold with a biodegradable polymer scaffold having a substantially elliptical body in longitudinal cross-section replicating the shape of a testicle and a substantially circular cross-section in transverse cross-section, the biodegradable scaffold defining an interior and an exterior of the prosthesis, and the scaffold being seeded with disassociated chondrocytes or Leydig cells, or both chondrocytes and Leydig cells. The interior of the prosthesis can be at least partially filled with testosterone.Type: GrantFiled: December 13, 2001Date of Patent: September 16, 2003Inventor: Anthony Atala
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Patent number: 6607556Abstract: Prosthetic implants designed to be implanted in the cornea for modifying the cornea curvature and altering the corneal refractive power for correcting myopia, hyperopia, astigmatism, and presbyopia, and, in addition, such implants formed of a micro-porous hydrogel material.Type: GrantFiled: September 6, 2000Date of Patent: August 19, 2003Assignee: Anamed, Inc.Inventor: Alok Nigam
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Patent number: 6602284Abstract: An expandable stent for implantation in a body lumen, such as an artery, is disclosed. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by one or more interconnecting members placed so that the stent is flexible in the longitudinal direction. The strength of the stent at a center section or at either end can be varied by increasing the mass of the struts forming each cylindrical element in that center section or end section relative to the lower mass struts in the remaining sections of the stent. Increasing the mass of the struts can be accomplished by, for a given strut thickness, increasing the width of the strut, or increasing the length of a cylindrical element.Type: GrantFiled: February 7, 2002Date of Patent: August 5, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Daniel L. Cox, Timothy A. Limon
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Patent number: 6592623Abstract: A muscle implant includes an extracellular matrix, tendon and muscle cells. The extracellular matrix is made of a matrix of electrospun polymer fibers. The tendon is made of extruded collagen fibers and the muscle cells are disposed on the extracellular matrix in such a manner that the combination of components will functionally and structurally act as normal muscle tissue. Cardiac and smooth muscles may be similarly formed without tendons but including the extracellular matrix and muscle cells.Type: GrantFiled: August 31, 1999Date of Patent: July 15, 2003Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: Gary L. Bowlin, Gary Wnek, David G. Simpson, Louis Terracio
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Patent number: 6585771Abstract: A protective cap for prosthetic joints having one element in the form of a ball head, especially in the case of hip end-prosthetic joints, protects the ball head when it is positioned and fixed on the cone of the shank by the surgeon by hand. A crown is arranged on the pole of the protective cap. The crown is in the form of a plate for, the shape of the plate and its extent relative to the protective cap being such that it is possible to grip behind the plate on the side that faces the protective cap.Type: GrantFiled: November 28, 2000Date of Patent: July 1, 2003Assignee: Ceramtec AG Innovative Ceramic EngineeringInventors: Manek Buttermilch, Ernst Hoch, Hartmut Kalberer, Paul Silberer
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Patent number: 6582471Abstract: The composition as described serves for in vivo cartilage repair. It basically consists of a naturally derived osteoinductive and/or chondroinductive mixture of factors (e.g. derived from bone) or of a synthetic mimic of such a mixture combined with a nanosphere delivery system. A preferred mixture of factors is the combination of factors isolated from bone, known as BP and described by Poser and Benedict (WO 95/13767). The nanosphere delivery system consists of nanospheres defined as polymer particles of less than 1000 nm in diameter (whereby the majority of particles preferably ranges between 200-400 nm) in which nanospheres the combination of factors is encapsulated. The nanospheres are loaded with the mixture of factors in a weight ratio of 0.001 to 17% (w/w), preferably of 1 to 4% (w/w) and have a release profile with an initial burst of 10 to 20% of the total load over the first 24 hours and a long time release of at least 0.1 per day during at least seven following days.Type: GrantFiled: September 13, 2000Date of Patent: June 24, 2003Assignee: Sulzer Innotec AGInventors: Pedro Bittmann, Brent Atkinson, James J. Benedict, John Ranieri, Marsha L. Whitney, Donald Chickering
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Patent number: 6576019Abstract: The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural polymeric matrix shaped to conform to at least a part of the luminal organ or tissue structure with a first cell population on or in a first area and a second cell population such as a smooth muscle cell population in a second area of the polymeric matrix. The method involves grafting the device to an area in a patient in need of treatment. The polymeric matrix comprises a biocompatible and biodegradable material.Type: GrantFiled: July 17, 2000Date of Patent: June 10, 2003Assignee: Children's Medical Center CorporationInventor: Anthony Atala
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Patent number: 6576012Abstract: An binocular lens system for improving the vision of a patient including first and second ophthalmic lenses. Each of these lenses is adapted for implantation in an eye or to be disposed on or in the cornea. The first lens has a first baseline diopter power for distance vision correction and the second ophthalmic lens has a second baseline diopter power for other than distance vision correction. The ophthalmic lenses may be intraocular lenses which are implanted in the eyes of a patient or has natural lenses or following removal of the natural lenses.Type: GrantFiled: March 28, 2001Date of Patent: June 10, 2003Assignee: Advanced Medical Optics, Inc.Inventor: Alan J. Lang
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Patent number: 6572650Abstract: The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.Type: GrantFiled: June 11, 2001Date of Patent: June 3, 2003Assignees: Organogenesis Inc., Duke University School of MedicineInventors: Ginger A. Abraham, Robert M. Carr, Jr., Tam Huynh, Otto Per Hagen, Mark Davies
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Patent number: 6569199Abstract: An intraocular lens implant including a telescope body defining an optical path for light to pass therethrough, at least one lens attached to the telescope body, mounting structure connected to the telescope body for mounting the implant in an eye, and an optical blocker disposed in the implant outside of the optical path which minimizes a transmission of light outside the optical path but does not impede transmission of light through the optical path.Type: GrantFiled: October 3, 2000Date of Patent: May 27, 2003Inventors: Gideon Dotan, Eli Aharoni, Isaac Lipshitz, David Klein
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Patent number: 6569194Abstract: A radiopaque nitinol stent for implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element including tungsten. The added tungsten in specified amounts improve the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same strut pattern coated with a thin layer of gold. Furthermore, the nitinol stent has improved radiopacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.Type: GrantFiled: December 28, 2000Date of Patent: May 27, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Brian Lee Pelton
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Patent number: 6569204Abstract: A composition for use in bone tissue regeneration and a method for its preparation, for application principally, but not exclusively, in the practice of oral surgery. The composition makes use of a gel of plasma rich in growth factors (P.R.G.F.) obtained from blood extracts from the patient undergoing the treatment, facilitating a regeneration of the graft site which is more rapid and effective than the results given by currently known materials and techniques.Type: GrantFiled: December 12, 2000Date of Patent: May 27, 2003Inventor: Eduardo Anitua Aldecoa
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Patent number: 6565599Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as a coronary artery. The stent consists of radially expandable cylindrical rings generally aligned on a common axis and interconnected by one or more links. At least some of the links are formed of a polymer material providing longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the rings along the longitudinal axis.Type: GrantFiled: December 28, 2000Date of Patent: May 20, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventors: James Hong, Timothy A. Limon
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Patent number: 6562070Abstract: An anterior chamber phakic lens made from an elastomeric, foldable, highly biocompatible material. The lens has a generally circular optic and integrally formed plate-style haptics, the haptics containing an opening into which project a pair of pincer arms. the pincer arms are sized and shaped so as to pull away from each other when the lens is folded, and are draw back toward each other when the folded lens is released and allowed to return to its unfolded state. Such movement allows the pincers to gather a small section of the iris so as to hold the lens in place.Type: GrantFiled: January 9, 2002Date of Patent: May 13, 2003Assignee: Alcon, Inc.Inventors: Son Trung Tran, Stephen J. Van Noy
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Patent number: 6554857Abstract: A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of proteinaceous and synthetic layers or gradients. Each layer within the matrix is designed to achieve a specific function, such as facilitation of ingrowth of a particular cell type or release of a particular growth factor. The well-defined porosity is in the form of either helically oriented, interconnected transmural ingrowth channels, or a porous wall structure containing uniformly shaped pores (i.e. voids) in a very narrow size range, or a combination of channels and pores. This invention allows for uninterrupted ingrowth of connective tissue into walls of a synthetic graft prosthesis made from the prosthetic material. Furthermore, this invention can produce small diameter prostheses having an internal diameter of 6 mm or less.Type: GrantFiled: November 5, 1999Date of Patent: April 29, 2003Assignee: Medtronic, INCInventors: Peter Paul Zilla, Deon Bezuidenhout, Theresa Yvonne Dower
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Patent number: 6547812Abstract: A method and apparatus for inhibiting vascular restenosis using a radioactive implantable medical device and a radiosensitizer agent. In one embodiment, the method of the invention includes implanting a medical device at a blood vessel site that has undergone a procedure to open a stenosed region within a blood vessel. The medical device contains a radioisotope to emit a radioactivity to a tissue mass at the blood vessel site. The method further includes delivering a radiosensitizer agent to the tissue mass at the blood vessel site. The radiosensitizer agent increases a therapeutic response of the tissue mass to the radioactivity emitted by the radioisotope.Type: GrantFiled: December 29, 2000Date of Patent: April 15, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventor: Ty T. Hu
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Patent number: 6547822Abstract: An ophthalmic lens system for improving the vision of a patient including first and second ophthalmic lenses. Each of these lenses is adapted for implantation in an eye or to be disposed on or in the cornea. The first ophthalmic lens is biased for distance vision and the second ophthalmic lens is biased for intermediate vision. The ophthalmic lenses may be intraocular lenses which are implanted in the eyes of a patient without removal of the natural lens.Type: GrantFiled: May 3, 2000Date of Patent: April 15, 2003Assignee: Advanced Medical Optics, Inc.Inventor: Alan J. Lang