Patents Examined by Holly Kipouros
  • Patent number: 12037574
    Abstract: A method includes placing a sample of cells, tissue, or an organ into an oxygen imaging system, circulating a humidified gas mixture around the tissue or organ, circulating conditioned air through the oxygen imaging system to maintain a temperature around the sample, and acquiring a three-dimensional oxygen map of the sample. The oxygen map provides a quantitative measure of cell viability and functionality.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: July 16, 2024
    Assignee: O2M Technologies, LLC
    Inventors: Mrignayani Kotecha, Boris Meerovich Epel, Eliyas Siddiqui, Safa Hameed
  • Patent number: 12037575
    Abstract: Provided are a method and an apparatus for isolating stromal cells from biological tissue without using an enzyme, in which spontaneous migration of the stromal cells of the biological tissue is induced to move the stromal cells to the outside of the biological tissue, wherein the induction of the spontaneous migration of the stromal cells is performed in a state in which the biological tissue is attached to an attachment member formed of a material to which biological tissue is attachable, and is performed in a culture medium in which the stromal cells can survive.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: July 16, 2024
    Inventor: Hee Young Lee
  • Patent number: 12022823
    Abstract: An automated bioreactor system for decellularizing an organ includes a main chamber for containing the organ. The system further includes a reagent chamber containing a liquid phase reagent. A reagent conduit delivers the liquid phase reagent to the main chamber, and a perfusion conduit delivers the reagent from the reagent outlet in the main chamber into the organ. A perfusion pump drives the flow of the reagent. A perfusion pressure sensor detects a pressure of the flowing reagent. A control system controls the perfusion pump to drive the flow of the reagent based on a received input representative of a desired pressure and a received input of the detected pressure. The control system may automatically perform all of the steps of a decellularization protocol based on sensor input. An automated waste decontamination system may also be provided.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: July 2, 2024
    Assignee: United Therapeutics Corporation
    Inventors: Ryan Bonvillain, John Cheadle, Thomas Petersen
  • Patent number: 12023626
    Abstract: The present invention provides a system for capturing and recycling carbon dioxide in an exhaust gas, which includes a CO2 capture unit into which an exhaust gas containing CO2 is input, and which captures the CO2 as a high concentration enriched gas and separates a first treatment gas; a mineralization process unit which mineralizes the CO2 after receiving the high concentration enriched gas captured in the CO2 capture unit and discharges a second treatment gas; a mixing tank which receives the first treatment gas and the second treatment gas and mixes them so that the contained CO2 has a predetermined concentration; a photo-culture process unit which receives the resulting third treatment gas from the mixing tank to perform a photo-culture process using microalgae; and a control unit which controls the flow rates and the CO2 contents of the gases supplied and discharged to/from the CO2 capture unit, the mineralization process unit, the mixing tank and the photo-culture process unit.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: July 2, 2024
    Assignee: Korea District Heating Corp.
    Inventors: Won Seok Chang, Yoon Soo Choi, Mun Sei Oh, Kyung Min Kim, Ji Hye Yu, Young Jae Lee
  • Patent number: 12016329
    Abstract: A technique is disclosed for preserving a shape of a fragile object in a liquid. The technique includes a device including a container that houses a fragile object and has a cylindrical shape including a bottom, a lid that seals the container, and a seal. The container includes a lower portion that houses the fragile object, an upper portion that includes an opening, and a stepped portion provided between the lower portion and the upper portion. The lid seals the opening of the upper portion. The seal is interposed between the lid and the stepped portion to seal an opening of the lower portion.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: June 25, 2024
    Inventors: Ryohei Takeuchi, Toshikazu Takeuchi
  • Patent number: 12011510
    Abstract: Disclosed herein is systems, methods, and apparatuses for treating biological fluids. In some embodiments, the biological fluid treatment system includes a treatment, a platform, an array of light sources, and a display. In some embodiments, the biological fluid treatment system includes a scanner.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: June 18, 2024
    Assignee: Cerus Corporation
    Inventors: Daniel Church, Lloyd Ison, Marc Stern
  • Patent number: 11999933
    Abstract: A biological sheet culture device includes a scaffold, a number of culture dishes for culturing biological sheets positioned on the scaffold and at least one fluid channel configured to traverse each culture dish.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: June 4, 2024
    Inventor: Shi Zhou
  • Patent number: 11999931
    Abstract: A microfluidic device for processing cells for the intracellular delivery of molecules or other cargo includes a plurality of microchannels disposed in a substrate or chip and fluidically coupled to an inlet configured to receive a solution containing the cells and the molecules or other cargo to be delivered intracellularly to the cells. Each of the plurality of microchannels has one or more constriction regions therein, wherein the constriction regions comprise an omniphobic, superhydrophilic, or superhydrophobic surface. In some embodiments, multiple microfluidic devices operating in parallel are used to process large numbers of cells. The device and method has particularly applicability to delivering gene-editing molecules intracellularly to cells.
    Type: Grant
    Filed: August 19, 2017
    Date of Patent: June 4, 2024
    Inventors: Steven J. Jonas, Paul S. Weiss, Xu Hou, Joanna Aizenberg, Alireza Khademhosseini
  • Patent number: 11993765
    Abstract: A container for use in growing, culturing and/or modifying cells has a primary container (10) and defines an internal lumen in which a wall element (8) of the primary container (10) is compressible, and wherein the container has an auxiliary container (16) in fluid communication with the primary container (10). The fact that the device has an auxiliary container 16 allows a number of separate reactions to be carried out within a single container.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 28, 2024
    Assignee: Silicon Valley Bank UK Limited
    Inventors: Farlan Veraitch, Christopher Mason
  • Patent number: 11987781
    Abstract: The present invention relates to a gas collection device and is directed to a gas collection device for collecting a gas which is generated while microorganisms are cultured in a super absorbent polymer product. The gas collection device may comprise a constant temperature chamber having an interior that is configured to be maintained at a set temperature; a culture flask unit located inside the constant temperature chamber and configured to culture a bacteria therein; an adsorption unit located outside the constant temperature chamber and configured to receive a gas inside the culture flask unit; a pump unit connected to a rear end of the adsorption unit and configured to suck the gas inside the culture flask unit into the adsorption unit; and a mass flow controller located outside the constant temperature chamber and configured to control a flow rate of the gas sucked into the adsorption unit.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: May 21, 2024
    Assignee: LG Chem, Ltd.
    Inventors: Eun Byeol Ko, Jung Hye Won, Nak Hee Choi, Ji Seok Lee, Eun Yeong Jin, Hae Sung Yun
  • Patent number: 11975319
    Abstract: The invention relates to a dispensing device having a dispenser for dispensing a liquid containing at least one cell and/or at least one particle and an optical detection device for optically detecting at least a region of the dispenser, which has a light source for emitting an illuminating light for illuminating the region and a deflection device for deflecting a detection light emanating from the region. The dispensing device is characterised in that the deflection device deflects the detection light at least twice, in particular exactly twice.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: May 7, 2024
    Assignee: CYTENA GMBH
    Inventors: Jonas Schöndube, Lena Lautscham
  • Patent number: 11965876
    Abstract: The present disclosure generally pertains to a biomimetic apparatus configured to simulate physiological conditions by, in part, providing for both barrier and transport interfaces. The presently disclosed apparatus may be used to: test therapeutics for different diseases; to study transport; form a substrate for any organ tissue with a barrier and/or transport function; provide a closed loop assembly for fluid flow; mimic underlying and enveloped tissue; and model external environmental conditions.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: April 23, 2024
    Inventor: Karim I. Budhwani
  • Patent number: 11959059
    Abstract: It is described an orbital incubator shaker, which comprises an incubator housing (1) defining an incubation chamber (2), and an orbital shaker (3) configured to shake a shaking table (4). The orbital shaker (3) comprises a rotary direct drive motor (7, 8, 9, 10) comprising a stator (7, 8) and a rotor (9, 10) comprising a rotor shaft (9), and an eccentric bearing unit (11, 12, 14) mounted on the rotor shaft (9). The stator (7, 8) is located outside the incubation chamber (2) and the rotor shaft (9) extends from a space (22) outside the incubation chamber (2) towards the incubation chamber (2).
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: April 16, 2024
    Inventor: Winfried Merk
  • Patent number: 11957817
    Abstract: A method for degrading an organism includes steps as follows. A composite structure is provided, wherein the composite structure includes a degradation activity donor and a supporter. The degradation activity donor has a piezoelectric property. The supporter carries the degradation activity donor, wherein the degradation activity donor is completely or partially covered by the supporter. A contacting step is conducted, wherein the composite structure is contacted with a medium. The medium includes at least one organism and water. A degrading step is conducted, wherein a mechanical perturbation is generated in the medium to polarize the degradation activity donor, and a separation of an electron-hole pair is generated for degrading the organism.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: April 16, 2024
    Inventors: Jyh-Ming Wu, Srinivaas Masimukku
  • Patent number: 11959056
    Abstract: The disclosure relates generally to a cell culture apparatus and a cell culture method. One aspect of the disclosure provides a perfusion cell culture bag comprising one or more polymer films, having edges bonded together to form edges around an undivided interior compartment of the bag; first and second ports each formed in an exterior surface of the bag; first and second liquid-permeable tubes each extending into and in fluid communication with the interior compartment of the bag and operatively coupled to a respective port; and a third port formed in an exterior surface of the bag, the third port being in fluid communication with the interior compartment of the bag; wherein the first tube comprises a first inner support structure defining a central lumen of the tube and a first outer filter layer surrounding the first inner support structure.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: April 16, 2024
    Assignee: Saint-Gobain Performance Plastics Corporation
    Inventors: Robert G. Pleydon, Natasha Anna Boghosian, Jacob Andrews, Phillippe Jean Broussard
  • Patent number: 11951223
    Abstract: A method and an apparatus are provided for cleaning, disinfecting, and/or sterilizing a device. The method comprises contacting an object with an obstructing substance such that the object is infiltrated with at least a portion of the obstructing substance. An absorptive and/or adsorptive capacity of the object is reduced by the obstructing substance. The object is contacted with a treatment agent after the capacity of the object is reduced. Infiltration of the object with the treatment agent is limited by the reduction of the capacity of the object.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: April 9, 2024
    Assignee: ASP Global Manufacturing GMBH
    Inventor: Roger Vu
  • Patent number: 11946027
    Abstract: Systems and methods for monitoring and tracking the behavior of cells and tissues in a culturing medium, for example, in a cell culture medium or an in vivo tissue environment, using a tissue scaffold system having one or more sensor arrays. Such monitoring systems include a tissue scaffold system and one or more sensor arrays on the tissue scaffold system in vertically stackable configurations. The sensor array(s) are configured to monitor electrical impedance and/or electrophysiological activities of cells or tissues which may be provided to an external data acquisition system for production of a three-dimensional (3D) map.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: April 2, 2024
    Assignee: Purdue Research Foundation
    Inventor: Chi-Hwan Lee
  • Patent number: 11926814
    Abstract: Provided herein are systems comprising multiple fluidically-coupled chamber volumes. In particular, provided herein are cell culture systems that incorporate fluid flow between multiple cell culture volumes, and method of use thereof for the culture of multiple related cell/tissue types.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: March 12, 2024
    Assignee: Northwestern University
    Inventors: Hunter B. Rogers, Teresa K. Woodruff
  • Patent number: 11912972
    Abstract: A system for culturing cells includes a bioreactor including a scaffold on which the cells tend to adhere. The system further includes a circulatory system that intermittently flows fluid over the scaffold.
    Type: Grant
    Filed: March 30, 2023
    Date of Patent: February 27, 2024
    Assignee: Ark Biotech Inc.
    Inventors: Zheng Huang, Natalie Rose Rubio, Orianna Elysse Kane
  • Patent number: 11905504
    Abstract: A body cube for culturing tissue that includes: an organ chip holder; and a body barrier chip and a first body organ chip disposed in the organ chip holder, the first body organ chip including a first cell culture chamber that receives cell culture medium and produces a first tissue in the first cell culture chamber, such that the organ chip holder receives cell culture medium and communicates the cell culture medium to the first cell culture chamber of the first body organ chip in response to rotation of the organ chip holder.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: February 20, 2024
    Inventors: Mandy Brigitte Esch, Longyi Chen