Patent number: 6673804
Abstract: A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:
R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6.
A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6 is a group (II), (III), (IV)
X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7 and R8 is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12 is H, alkyl, etc. Each of m and n is 0 to 2. R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4 is optionally substituted (hetero)arylene. R5 is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
Type:
Grant
Filed:
October 2, 2000
Date of Patent:
January 6, 2004
Assignee:
Sankyo Company, Limited
Inventors:
Tomio Kimura, Shoujiro Miyazaki, Keiji Ueda, Kazuhiko Tanzawa, Shigeru Ushiyama, Wataru Takasaki
Patent number: 6620812
Abstract: A sulfamoyl compound of the general formulae (1):
wherein
R1 and R2 are each independently C1-4 alkyl, or R1 and R2 together are C4-6 alkylene or C4-6 alkyleneoxy,
Y is H, halogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C1-8 haloalkyl, C1-8 haloalkoxy or C1-8 haloalkylthio,
A is a predetermined heterocyclic group,
B is a predetermined heterocyclic group which is identical with or different from A,
W is a chemical bond or O,
V is O or S,
D, E, F and G are each independently N, CR7, CR8, CR9 or CR10, and
R3, R4, R5, R6, R7, R8, R9, R10 and R11 are each independently predetermined group such as H, or an unsubstituted or substituted aliphatic, aromatic or heterocyclic group. The sulfamoyl compound is useful as an agricultural and horticultural fungicide.
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
September 16, 2003
Assignee:
Nissan Chemical Industries, Ltd.
Inventors:
Toshiaki Takeyama, Toshimasa Hamada, Hiroaki Takahashi, Junichi Watanabe, Kazuhiro Yamagishi, Masanori Nishioka, Hiroyuki Suzuki