Abstract: The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at least one inverted terminal repeat (ITR) Sequence from AAV and a heterologous DNA Sequence.
Type:
Grant
Filed:
September 12, 1996
Date of Patent:
March 7, 2000
Assignee:
Rhone-Poulenc Rorer S.A.
Inventors:
Martine Latta, Patrice Denefle, Emmanuelle Vigne, Michel Perricaudet