Patents Examined by Hope Robinson
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Patent number: 11965198Abstract: The present invention provides a method for producing a target substance, the biosynthetic pathway of which is ATP-dependent, for example, amino acids, nucleosides, nucleotides, isoprenoids, and peptides, by fermentation of a bacterium which has been modified to overexpress a gene encoding a protein having H+-translocating membrane-bound pyrophosphatase activity, for example, the hppA gene native to R. rubrum or a variant thereof.Type: GrantFiled: April 2, 2021Date of Patent: April 23, 2024Assignee: AJINOMOTO CO., INC.Inventors: Ekaterina Andrianova, Maria Kharchenko, Natalia Zakataeva, Elvira Voroshilova, Aleksander Krylov, Evgeniya Malykh, Sergei Mashko, Natalia Stoynova, Mikhail Baboshin, Lyubov Golubeva, Ekaterina Kovaleva, Mikhail Shupletsov
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Patent number: 11965191Abstract: The present disclosure relates to systems, methods and compositions provided herein that include a compound protease. The compound protease can contain a protease domain, a cut site for another enzyme and an association domain. In some embodiments, the compound protease is part of a protein circuit.Type: GrantFiled: January 25, 2021Date of Patent: April 23, 2024Assignee: California Institute of TechnologyInventors: Xiaojing Gao, Lucy S. Chong, Michael Elowitz, Mark William Budde, Matthew Sun-min Kim
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Patent number: 11959107Abstract: The present invention relates to variants of an alpha-amylase having improved stability to chelating agents relative to its parent enzyme, compositions comprising the variants, nucleic acids encoding the variants, methods of producing the variants, and methods for using the variants.Type: GrantFiled: August 22, 2022Date of Patent: April 16, 2024Assignee: Novozymes A/SInventors: Allan Svendsen, Annette Helle Johansen, Mads Bjoernvad, Frank W. Rasmussen, Michael Skjoet, Signe Eskildsen Larsen, Jens Oebro, Svend Kaasgaard, Lars Beier
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Patent number: 11958918Abstract: The present invention relates to chitin with a differential purity of more than 97.75% and to a process for producing chitin and/or chitosan by the enzymatic and chemical pathway.Type: GrantFiled: December 13, 2018Date of Patent: April 16, 2024Assignee: YNSECTInventors: Lorena Sanchez, Cecilia Socolsky, Valérie Alezra, Corentin Le Berre, Bénédicte Lorette, Sophie Laurent, Nathalie Berezina
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Patent number: 11958886Abstract: The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.Type: GrantFiled: December 7, 2017Date of Patent: April 16, 2024Assignee: University of Florida Research Foundation, IncorporatedInventor: Steven C. Ghivizzani
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Patent number: 11959891Abstract: Disclosed is a proteomics sample preparation device, comprising a pipette tip, an ion exchange resin filler and a solid-phase extraction membrane. The solid-phase extraction membrane is filled into the lower end of the pipette tip, and the ion exchange resin filler is filled into the lower end of the pipette tip and is located above the solid-phase extraction membrane. The ion exchange resin filler is a strong cation exchange resin filler or a strong anion exchange resin filler. Disclosed is a protein chromatographic separation platform comprising the proteomic reactor and a liquid chromatography-mass spectrometer. Disclosed is the use of the proteomics reactor and protein chromatographic separation platform in the protein identification and protein quantitative analysis of a cell, a tissue or a blood sample.Type: GrantFiled: January 5, 2017Date of Patent: April 16, 2024Assignee: Shenzhen SheenviOmics Biotechnology Co., Ltd.Inventors: Ruijun Tian, Wendong Chen
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Patent number: 11946081Abstract: Disclosed herein is one or more subtilisin variant. nucleic acid encoding same. and compositions and methods related to the production and use thereof. including one or more Bacillus gibsonii-clade subtilisin variant that has improved soil removal compared to one or more reference subtilisin.Type: GrantFiled: December 19, 2017Date of Patent: April 2, 2024Assignee: Danisco US Inc.Inventors: Lilia Maria Babe, Lydia Dankmeyer, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius
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Patent number: 11946090Abstract: According to the present invention, there is provided a treatment process system for biomass material and methods for such system. The system comprises a first dewatering stage arranged to receive biomass material, to remove liquid from the biomass material, and to feed the biomass material forward in the process. Further, the system includes a water treatment stage arranged to collect the removed liquid and an addition stage located downstream said dewatering stage and operatively coupled to the first dewatering stage. The addition stage is arranged to receive the de-watered biomass material, wherein the addition stage includes inlets for adding acid containing solution into the addition stage. A reactor stage arranged to receive the biomass material treated in the addition stage and to perform a pre-hydrolysis process to the biomass material. A filtrate feeding arrangement is arranged to feed liquid from the filtrate tank to the reactor stage.Type: GrantFiled: May 29, 2019Date of Patent: April 2, 2024Assignee: VALMET ABInventors: Örjan Ahlgren, Johan Carlsson, Anders Löfström, Patrik Pettersson
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Patent number: 11939608Abstract: Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.Type: GrantFiled: March 18, 2022Date of Patent: March 26, 2024Inventors: Michael Super, Alexander L. Watters, Philip T. Snell, Donald E. Ingber
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Patent number: 11939602Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.Type: GrantFiled: November 30, 2022Date of Patent: March 26, 2024Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
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Patent number: 11932896Abstract: The present invention provides for a composition comprising: (a) a first host cell capable of producing L-DOPA; and (b) a modified host cell is capable of converting L-DOPA into hydroxytyrosol (HTy); wherein any one or both of the first host cell and second host cell is a genetically modified host cell.Type: GrantFiled: December 26, 2018Date of Patent: March 19, 2024Assignee: The Regents of the University of CaliforniaInventors: Erika Yoshida, Taek Soon Lee
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Patent number: 11932887Abstract: The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as Mirabilis. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.Type: GrantFiled: July 28, 2020Date of Patent: March 19, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Guy Polturak
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Patent number: 11919928Abstract: An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.Type: GrantFiled: October 12, 2021Date of Patent: March 5, 2024Assignee: KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Takashi Kubo, Masayuki Machida, Tomonori Fujioka, Shigenari Yamaguchi, Kiyoshi Kawai
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Patent number: 11913043Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.Type: GrantFiled: November 4, 2021Date of Patent: February 27, 2024Assignee: Research Development FoundationInventors: Xinjian Lin, Xiying Shang, Stephen B. Howell
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Patent number: 11913039Abstract: A method of producing recombinant alkaline phosphatase comprising control of production parameters, particularly harvest clarified culture fluid (HCCF) and filtration pool (UFDF), to provide a defined total sialic acid content.Type: GrantFiled: March 13, 2019Date of Patent: February 27, 2024Assignee: Alexion Pharmaceuticals, Inc.Inventors: Rahul Godawat, Meghan Dewitt, Siguang Sui, Saravanamoorthy Rajendran
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Patent number: 11898180Abstract: Compositions and methods for the preparation of high purity arginase and high efficiency preparation of monosubstituted polyethylene glycol conjugation of arginase are provided, as are methods for using arginase in combination with asparaginase to inhibit cancer cells. High purity arginase is provided by applying an initial high temperature precipitation step, followed by ion exchange to provide arginase at a purity of 90% or greater. Conjugation with either linear or branched polyethylene glycol is performed using a maleimide-derivatized polyethylene glycol at low molar excess relative to arginase and at reduced temperature. Such polyethylene glycol-derivatized arginase is useful in combination with asparaginase in inhibiting the growth of cancer cells, particularly cells that have low endogenous asparaginase expression.Type: GrantFiled: August 16, 2018Date of Patent: February 13, 2024Assignee: Avalon Polytom (HK) LimitedInventors: Johnson Yiu-Nam Lau, Yun Chung Leung, Kuo-Ming Yu, Yuk-Keung Yeung, Pui Shi Pang, Qui-Lim Choo
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Patent number: 11896024Abstract: The present invention relates to compositions, particularly liquid compositions, comprising enzymes, methods of making the compositions, and uses of the same for making, e.g., dairy products.Type: GrantFiled: March 7, 2022Date of Patent: February 13, 2024Assignee: Novozymes A/SInventor: Jeppe Wegener Tams
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Patent number: 11897924Abstract: Disclosed is a fusion protein including an Ixodes ricinus salivary gland polypeptide. In particular, it relates to a fusion protein including at least one Ixodes ricinus salivary gland polypeptide, at least one serum albumin polypeptide and at least one linker peptide. Also disclosed is the use of such a fusion protein for preventing or treating thrombus formation and/or thrombus growth, as well as pharmaceutical compositions, medicaments and methods including such a fusion protein.Type: GrantFiled: March 28, 2019Date of Patent: February 13, 2024Assignee: BIOXODESInventors: Stéphanie Demoulin, Edmond Godfroid, Michel Guyaux, Joël Tassignon
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Patent number: 11891418Abstract: The present invention relates to a yeast cell of the Komagataella genus comprising an orthologous promoter of a methylotrophic yeast cell or a variant thereof inducible by derepression, wherein the orthologous promoter is an orthologous formate dehydrogenase (FMD) promoter of a methylotrophic yeast cell.Type: GrantFiled: December 22, 2016Date of Patent: February 6, 2024Assignee: BISY E.U.Inventors: Thomas Vogl, Anton Glieder
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Patent number: 11840714Abstract: The present invention provides a method of producing a composition containing docosahexaenoic acid as a constituent fatty acid of glycerides. The method includes hydrolyzing a feedstock oil containing glycerides, the glycerides including docosahexaenoic acid as a constituent fatty acid, by action of a first lipase and a second lipase, to increase the proportion of docosahexaenoic acid in glyceride fractions. The first lipase is at least one lipase selected from the group consisting of a lipase obtained from a microorganism of the genus Thermomyces, a lipase obtained from a microorganism of the genus Pseudomonas, a lipase obtained from a microorganism of the genus Burkholderia, and a lipase obtained from a microorganism of the genus Alcaligenes. The second lipase is a partial glyceride lipase.Type: GrantFiled: September 4, 2019Date of Patent: December 12, 2023Assignee: Nissui CorporationInventors: Yuuji Hirouchi, Isao Yamazaki, Natsuko Watanabe, Kiyomi Furihata