Patents Examined by Howard E. Schain
  • Patent number: 5079337
    Abstract: The subject of the invention is a water-soluble macromolecular conjugate of hemoglobin characterized in that it is constitutedon the one hand, by hemoglobin,on the other, by a water-soluble polymer P containing polar groups, this macromolecular conjugate contains Z sites, bound to the polymer P and containing at least one negative charge carried for example by sulfate groups, the polymer P being bound to hemoglobinon the one hand, through the intermediary of at least one linkage established between at least one of the Z sites contained in the polymer and hemoglobin,and, on the other, through the intermediary of at least one covalent linkage established between the polymer and hemoglobin, or between at least one of the Z sites contained in the polymer and hemoglobin.The macromolecular conjugates according to the invention exhibit a lower affinity for oxygen than that of free hemoglobin.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: January 7, 1992
    Assignee: Pasteur Merieux Serums et Vaccins S.A.
    Inventors: Michele Leonard, Edith Dellacherie, Jean M. L. Neel, Claude Vigneron, Pierre Labrude
  • Patent number: 5077391
    Abstract: Immunoglobulin M is purified by absorption upon an insoluble matrix material having chemically bound thereon the protein C1q. The matrix is washed and purified immunoglobulin M is then released from the matrix.
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: December 31, 1991
    Inventors: Robert L. Raison, Simon B. Easterbrook-Smith, Andrew G. Nethery
  • Patent number: 5077387
    Abstract: The present invention relates to a process for preparing peptide synthons in which the optical purity of each of the peptides to be condensed is retained.According to this process, a silyl derivative of an amino acid or peptide, which is activated by a complex chloroimmonium salt, a complex coordinated phosphorus halide, oxyhalide salt or a complex oxalyl halide salt, is prepared. The activated peptide is then condensed with an N-silyl amino acid or peptide in which the acid group is protected.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: December 31, 1991
    Assignee: Rhone-Poulenc Chimie
    Inventors: Robert Jacquier, Jean Verducci, Michel Ibea
  • Patent number: 5077388
    Abstract: Active recombinant human IL-4 is purified from a crude fermentation broth of a secreted E. coli mutant by subjecting said solution to selective chromatogrphy on a zinc-chelating agarose column at pH 7.2 in a buffer containing a high concentration of sodium chloride, i.e., about 1M sodium chloride, washing first with a phosphate buffer at pH 7.2 containing 1.0M sodium chloride then with a buffer containing 10% glycerol and eluting at pH 5.0. The resulting purified active recombinant human IL-4 solution is further treated by cation exchange chromatography, concentration by diafiltration up to 20 mg/mL and size exclusion gel chromatography using a citrate buffer at pH 4.5.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: December 31, 1991
    Assignee: Schering Corporation
    Inventors: John C. T. Tang, David Naveh, Tattanahali L. Nagabhushan
  • Patent number: 5075424
    Abstract: A process for producing .kappa.-casein glycomacropeptides which comprises adjusting the pH of a solution of milk starting materials containing the .kappa.-casein glycomacropeptides to below 4, treating the solution by ultrafiltration with a membrane having a fraction molecular weight of 10,000-50,000, and concentrating the obtained filtrate with a membrane having a fraction molecular weight of 50,000 or less.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: December 24, 1991
    Inventors: Morimasa Tanimoto, Yoshihiro Kawasaki, Hiroshi Shinmoto, Shunichi Dosako, Akira Tomizawa
  • Patent number: 5075425
    Abstract: Process for the preparation of an immunoglobulin solution suitable for intravenous administration from a human blood protein fraction containing immunoglobulins IgG, IgA and IgM in partially concentrated from, with the process steps: addition of acetate buffer to the protein fraction, where appropriate removal of insoluble constituents by filtration, treatment with calcium phosphate and octanoic acid, centrifugation, removal of the supernatant and treatment thereof with an adsorbent, removal of the adsorbent and sterilization by filtration.
    Type: Grant
    Filed: August 1, 1990
    Date of Patent: December 24, 1991
    Assignee: Biotest Pharma GmbH
    Inventors: Ronald Kotitschke, Wolfgang Stephan, Wolfgang Moller, Detlef Piechaczek, Dieter Rudnick
  • Patent number: 5073628
    Abstract: A novel hyposensitization agent was prepared by covalently attaching a saccharide to a cedar pollen allergen having a partial amino acid sequence of Ala-Ile-Asn-Ile-Phe-Asn- beginning at its N-terminal. The hyposensitization agent, when compared with an intact cedar pollen allergen, extremely accelerates the production of immunoglobulin G and M antibodies which are specific to intact cedar pollen allergen, but extremely reduces the production of immunoglobulin E antibody which is specific to the allergen. Thus, the hyposensitization agent is administrable to cedar pollinosis patients with no anaphylaxis and allergy, and cuts hyposensitization period to about 1/3 to 1/200.
    Type: Grant
    Filed: August 29, 1990
    Date of Patent: December 17, 1991
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tyoku Matsuhashi, Mitsuko Usui, Masakazu Mitsuhashi, Shunsaku Ando
  • Patent number: 5073630
    Abstract: The invention relates to a polymeric anhydride of magnesium and proteic ammonium phospholinoleate having the following distribution of components expressed in percentage of magnesium (20.1.+-.0.9%), Ammonium (10.0.+-.3.3%), Phosphate (45.2.+-.2.7%), linoleic acid (11.6.+-.4.3%), total protein (0.49.+-.0.07%) with the presence in percentage of the following aminoacids: Aspartic Acid (7.19%), Threonine (3.56%), Serine (7.56%), Glutamic Acid (8.53%), Proline (0.5%), Glycine (9.69%), Alanine (7.46%), Valine (1.0%), Methionine (4.38%), Isoleucine (2.54%), Leucine (3.03%), Thyrosine (0.5%), Phenylanine (1.0%), Histidine (2.83%), Lysine (3.56%), Tryptofan (1.3%) and Arginine (35.2%).This compound is produced from a selected line of Aspergillus sp in culture of oat schaff and bouillon at the temperature of 30.degree./35.degree. C., pH 3-4 with low aeration (10 l/m) and agitation (40 rph) restricted to the first 48 hours of the producing process.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: December 17, 1991
    Assignee: Nunes & Duran Pesquisa Comercio e Desenvolvimento Ltda.
    Inventors: Odilon D. Nunes, Nelson E. C. Duran
  • Patent number: 5073367
    Abstract: The present invention relates to a new method for increasing the productivity of sows.In the method according to the invention, Bacillus IP 5832 and/or its spores is/are administered orally to breeding sows.
    Type: Grant
    Filed: May 4, 1989
    Date of Patent: December 17, 1991
    Assignee: Guyomarc'h Nutrition Animale
    Inventor: Tan H. Nguyen
  • Patent number: 5071756
    Abstract: A type II, proteinaceous, antigenic factor derived from a Group A streptococci which is a receptor for the Fc region of human Ig G3 and which exhibits a major diffuse protein band on polyacrylamide gel electrophoresis and which has a molecular weight of about 38,000 daltons.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: December 10, 1991
    Assignee: University of Florida
    Inventors: Michael D. P. Boyle, Michele Yarnall
  • Patent number: 5071834
    Abstract: A pharmaceutical composition and method are provided for erythropoietin therapy, such as treatment of an anemic disease, wherein an effective amount of activin with two beta.sub.B chains formulated in a pharmaceutically acceptable carrier is administered to a patient or animal in need of such therapy. Preferably the activin is human and the composition is administered parenterally.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: December 10, 1991
    Assignee: Genentech, Inc.
    Inventors: Louis E. Burton, Anthony J. Mason, Charles H. Schmelzer
  • Patent number: 5071960
    Abstract: High molecular weight protein/fatty acid condensation products obtained by reaction of one mole of a protein hydrolysate of average molecular mass 3,000 to 7,000 with 0.5 to 3, preferably 2 to 2.5, moles of a C.sub.12 -C.sub.18 -fatty acid chloride in aqueous medium at a pH of 7 to 12. These protein/fatty acid condensation products are distinguished by eliciting no mucosal irritation whatever. They are therefore outstandingly suitable as surfactants for mild washing and cleansing agents.
    Type: Grant
    Filed: September 6, 1990
    Date of Patent: December 10, 1991
    Assignees: Hoechst Aktiengesellschaft, Deutsche Gelatine-Fabriken Stoess AG
    Inventors: Angelika Turowski, Jochen M. Quack, Alwin Reng, Arno Holst
  • Patent number: 5071955
    Abstract: A novel peptide possessing excellent antihypertensive activity is disclosed. The peptide has the formula:Pro-Thr-His-Ile-Lys-Trp-Gly-Asp (I)and can be prepared by purifying a fluid extracted from fish tissues or by combining constituting amino acids by a peptide synthesis method. It exhibits excellent ACE inhibitory activity, low toxicity, and good stability, and is thus an extremely useful and effective antihypertensive substance.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: December 10, 1991
    Assignees: Nippon Suisan Kaisha, Ltd., Mochida Pharmaceutical Co., Ltd.
    Inventors: Tsutomu Mimura, Yasuhiro Kohama, Mikio Satake, Yasukazu Nagase
  • Patent number: 5070188
    Abstract: The present invention provides acylated epidermal growth factor derivatives, methods of making the derivatives and pharmaceutical compositions containing the derivatives.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: December 3, 1991
    Assignee: Ethicon, Inc.
    Inventors: Francois K. Njieha, Shalaby W. Shalaby
  • Patent number: 5070186
    Abstract: Insulin preparations with improved properties for parenteral administration can be prepared at pH values of about 3 to 8.5 by presence of magnesium ions in concentration of about 0.005 to 0.5M, a preferred range is 0.02M to 0.5M.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: December 3, 1991
    Assignee: Novo Industri A/S
    Inventor: Klaus Joergensen
  • Patent number: 5066489
    Abstract: Therapeutic treatment of malignant melanoma in humans is disclosed wherein a synergistically effective amount of DTIC in combination with IL-2 is administered to an individual having such cancer.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: November 19, 1991
    Assignee: Cetus Corporation
    Inventors: Carolyn M. Paradise, Edward C. Bradley
  • Patent number: 5066491
    Abstract: Whey derived from ordinary milk includes a bottom fraction including lactose and minerals, a middle fraction including lower molecular weight proteins, and a top fraction including higher molecular weight proteins. The top whey fraction includes a measurable but low level concentration of immunologically active immunoglobulin plus other pathogen specific antibodies. The whey is ultrafiltered through one or more different process steps to yield a filtered product having a concentration of immunologically active immunoglobulin of at least about seven percent of total solids. The filtered product is periodically tested to verify its activity to a specified microbe. The filtered product is orally administered in a therapeutically effective dose to an animal to treat a disease.
    Type: Grant
    Filed: February 3, 1989
    Date of Patent: November 19, 1991
    Assignee: Protein Technology, Inc.
    Inventors: Gerald H. Stott, David O. Lucas
  • Patent number: 5066785
    Abstract: Methodology is described for the carboxyl-terminal sequencing of proteins and peptides using novel coupling reagents.
    Type: Grant
    Filed: February 17, 1989
    Date of Patent: November 19, 1991
    Assignee: City of Hope
    Inventor: Chad G. Miller
  • Patent number: 5064940
    Abstract: A novel and convenient process is described for providing protected amino acids and activating agents for solid phase synthesis which drastically reduces the capital costs of equipment required for the preparation of peptides. The two normally very reactive reagents, when mixed as anhydrous powders are shelf stable and yet form an active compound rapidly when mixed together in solution. This invention presents a method for combining these highly reactive dry solids in a manner which makes them unreactive and shelf stable at room temperature for extended periods of time. Once the solids are dissolved in solvent, a highly reactive amino acid ester that can readily be used in solid phase peptide synthesis is formed. This method of delivery of reagents to an automated peptide synthesizer allowers a very simplified instrument to be constructed using fewer and less expensive components and significantly reducing the associated software required.
    Type: Grant
    Filed: September 14, 1990
    Date of Patent: November 12, 1991
    Assignee: Protein Technologies, Inc.
    Inventors: Leon E. Barstow, Glen D. Ward
  • Patent number: 5063206
    Abstract: The present invention relates to methods of treating mental disorders and memory deficits not caused by HIV infection. The methods involve administration of a thymoleptic effective amount of defined linear peptides to patients. The peptides can be administered for example, as a powder or a solution obtained by dissolving a powder in a pharmaceutically acceptable solvent.
    Type: Grant
    Filed: May 16, 1989
    Date of Patent: November 5, 1991
    Assignee: The United States of Americas as represented by the Department of Health and Human Services
    Inventors: Peter Bridge, Frederick K. Goodwin