Abstract: A method for modifying the cell wall of single-cell microorganisms comprises treating the whole cells with a dilute solution of a source of perhalate ions to oxidize the structural polysaccharides in the cell wall without damaging the internal cellular components. If the treated cells are further treated with a dilute basic solution, the cells can be totally dissolved. The protein materials in this solution can then be recovered to obtain a variety of protein products that are whippable, coagulable, and soluble, etc.