Patents Examined by Ilia I Ouspenski
-
Patent number: 11976121Abstract: Disclosed are compositions and methods for targeted treatment of CD123-expressing cancers. In particular, chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill CD123-expressing cancers. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an anti-tumor immunity in a subject with a CD123-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.Type: GrantFiled: July 18, 2018Date of Patent: May 7, 2024Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.Inventor: Marco L. Davila
-
Patent number: 11970537Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.Type: GrantFiled: December 26, 2018Date of Patent: April 30, 2024Assignee: Nanjing GenScript Biotech Co., Ltd.Inventors: Zhongdao Li, Lixin Song, Wang Zhang, Yafeng Zhang, Dongliang Wang, Zhenyu Liu, Fangliang Zhang
-
Patent number: 11945871Abstract: The present invention relates to humanized antibodies that specifically bind to human BTN3A and their use in treating cancer and infectious disorders.Type: GrantFiled: June 1, 2023Date of Patent: April 2, 2024Assignees: IMCHECK THERAPEUTICS SAS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE AIX MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Alemseged Truneh, Daniel Olive, Christine Pasero, Aude De Gassart
-
Patent number: 11905327Abstract: Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TIGIT. Also provided are methods of making and using these constructs.Type: GrantFiled: December 28, 2018Date of Patent: February 20, 2024Assignee: Nanjing Legend Biotech Co., Ltd.Inventors: Wang Zhang, Shu Wu, Shuai Yang, Qi Pan, Chuan-Chu Chou
-
Patent number: 11903973Abstract: Genetically engineered hematopoietic cells such as hematopoietic stem cells having one or more genetically edited genes of lineage-specific cell-surface proteins and therapeutic uses thereof, either alone or in combination with immune therapy that targets the lineage-specific cell-surface proteins.Type: GrantFiled: February 16, 2021Date of Patent: February 20, 2024Assignee: VOR BIOPHARMA INC.Inventors: Joseph Bolen, Aleksandar Filip Radovic-Moreno, John Lydeard
-
Patent number: 11905334Abstract: It is to be understood that while the invention has been described in conjunction with the detailed description thereof, the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Other aspects, advantages, and modifications are within the scope of the following claims.Type: GrantFiled: February 5, 2021Date of Patent: February 20, 2024Inventors: Byoung S. Kwon, Hye Jeong Kim, Sunhee Hwang, Joongwon Lee, Seung Hyun Lee, Sun Woo Im, Jin Kyung Choi, Hyun Tae Son, Hyeok-Jun Park
-
Patent number: 11899019Abstract: Methods are provided for predicting a response to an anti-PD-1 antibody or anti-PD-L1 antibody therapy based on a new biomarker and for evaluating a malignancy of cancer. The method for predicting a response of a subject to an anti-PD-1 antibody or anti-PD-L1 antibody therapy includes measuring an expression level of LAT1 in a sample collected from a cancer tissue of the subject; and predicting a response of the subject to the anti-PD-1 antibody or anti-PD-L1 antibody therapy based on the expression level of LAT1. The method for evaluating a malignancy of cancer in a subject includes staining a sample collected from a cancer tissue of the subject with an anti-LAT1 antibody and an anti-PD-L1 antibody; and evaluating a malignancy of the cancer in the subject based on a presence or absence of a LAT1-positive and PD-L1-positive site.Type: GrantFiled: November 7, 2018Date of Patent: February 13, 2024Assignees: J-PHARMA CO., LTD., NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, OSAKA UNIVERSITYInventors: Hitoshi Endou, Goshi Ishihara, Kyoichi Kaira, Yoshikatsu Kanai
-
Patent number: 11899017Abstract: The present disclosure relates to the finding that the ratio of circulating (i.e., peripheral blood) central memory T cells to circulating effector T cells in a cancer patient can predict whether a tumor has an inflammatory milieu or not. In addition, since having an inflammatory milieu (“hot tumor”) is a positive factor for responding to checkpoint inhibitors, e.g., PD-1 antagonists, this assay on peripheral blood can also be used to predict a response to a checkpoint inhibitor, e.g., an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity or an antibody or an antigen binding portion thereof that binds specifically to PD-1 ligand 1 (PD-L1) and inhibits PD-L1 activity.Type: GrantFiled: July 27, 2018Date of Patent: February 13, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Nataly Manjarrez Orduño, Suzanne J. Suchard
-
Patent number: 11897955Abstract: A monoclonal antibody or a derivative thereof that binds to a human TIGIT antigen with high-affinity and antagonistically inhibits the binding of TIGIT to a ligand thereof such as CD155 is provided. Amino acid sequences of antigen complementarity-determining regions CDR-L1, CDR-L2 and CDR-L3 of an antibody light chain variable region, and amino acid sequences of antigen complementarity-determining regions CDR-H1, CDR-H2 and CDR-H3 of an antibody heavy chain variable region are specified. Further, a humanization preparation method for the antibody and amino acid sequences of the heavy chain variable region and light chain variable region of the humanized antibody are provided. The antibody or the derivative thereof can serve as an ingredient of a pharmaceutical composition or can be prepared into an appropriate drug preparation, and administered alone or in combination with other medications, such as an anti-PD-1 monoclonal antibody, or treatment means, for treating diseases such as tumors.Type: GrantFiled: July 15, 2020Date of Patent: February 13, 2024Assignee: ACROIMMUNE BIOTECH CO., LTD.Inventors: Qunmin Zhou, Weiwei Sun, Zui Chen, Xiaoxiao Ma, Jinling Fan, Hongqun Hu
-
Patent number: 11884737Abstract: The present invention relates to a method of treating an autoimmune or inflammatory disease or a neurodegenerative disease with an antibody to CD154.Type: GrantFiled: June 29, 2021Date of Patent: January 30, 2024Assignees: UCB BIOPHARMA SRL, BIOGEN MA INC.Inventors: Ruth Oliver, Miren Zamacona
-
Patent number: 11884724Abstract: The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.Type: GrantFiled: August 4, 2020Date of Patent: January 30, 2024Assignee: Merck Patent GmbHInventors: Horacio G. Nastri, Christel Iffland, Olivier Leger, Qi An, Mark Cartwright, Sean D. McKenna
-
Patent number: 11884727Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session.Type: GrantFiled: February 26, 2021Date of Patent: January 30, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Michal Eisenbach-Schwartz, Kuti Baruch, Neta Rosenzweig
-
Patent number: 11884728Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.Type: GrantFiled: February 26, 2021Date of Patent: January 30, 2024Assignee: Yeda Research and Development Co. Ltd.Inventors: Michal Eisenbach-Schwartz, Kuti Baruch, Neta Rosenzweig
-
Patent number: 11878058Abstract: There is disclosed compositions and methods relating to or derived from anti-PD-L1 antibodies. More specifically, there is disclosed fully human antibodies that bind PD-L1, PD-L1-binding fragments and derivatives of such antibodies, and PD-L1-binding polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PD-L1 related disorders or conditions, including various inflammatory disorders and various cancers.Type: GrantFiled: May 3, 2021Date of Patent: January 23, 2024Assignee: Sorrento Therapeutics, Inc.Inventors: Heyue Zhou, Randy Gastwirt, Barbara A. Swanson, John Dixon Gray, Gunnar F. Kaufmann
-
Patent number: 11866494Abstract: The present disclosure relates to compositions and methods for enhancing CAR T therapy through uses of co-stimulation. Some embodiments relate to an isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR) and an agent associated with a co-stimulatory molecule, the CAR comprising an intracellular domain of a costimulatory molecule.Type: GrantFiled: August 27, 2019Date of Patent: January 9, 2024Assignee: Innovative Cellular Therapeutics Holdings, Ltd.Inventors: Zhiyuan Cao, Chengfei Pu, Lei Xiao, Zhao Wu
-
Patent number: 11866510Abstract: The invention relates to chimeric antigen receptors (CAR) that comprise one or more single human variable domain antibody and cells that express such CAR. In particular, the invention relates to CARs that include multiple single human variable domain antibodies. In a particular embodiment, the one or more single human variable domain antibody binds to prostate membrane antigen.Type: GrantFiled: May 8, 2017Date of Patent: January 9, 2024Assignee: CRESCENDO BIOLOGICS LIMITEDInventors: Brian McGuinness, Colette Johnston
-
Patent number: 11860161Abstract: Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.Type: GrantFiled: August 5, 2019Date of Patent: January 2, 2024Assignee: Seattle Children's HospitalInventors: Neelufar Mozaffarian, Anne M. Stevens
-
Patent number: 11858997Abstract: The present invention relates to amino acid sequences that block the interaction between (a target on) an antigen presenting cell (APC) and (a target on) a T-cell. More particularly, the present invention relates to amino acid sequences that are directed against (as defined herein) a target on an APC (also referred to herein as “APC target”) or a target on a T-cell (also referred to herein as “T-cell target”). The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences.Type: GrantFiled: October 13, 2020Date of Patent: January 2, 2024Assignee: Ablynx N.V.Inventors: Guy Hermans, Peter Verheesen, Edward Dolk, Hendricus Renerus Jacobus Mattheus Hoogenboom, Michael John Scott Saunders, Hans De Haard, Renee de Bruin
-
Patent number: 11858996Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.Type: GrantFiled: August 9, 2017Date of Patent: January 2, 2024Assignee: KYMAB LIMITEDInventors: Richard Charles Alfred Sainson, Stephen John Arkinstall, Jamie Iain Campbell, Mohammed Hanif Ali, E-Chiang Lee, Matthew John McCourt, Volker Germaschewski, Ian Kirby, Miha Kosmac, Nahida Parveen, Robert Rowlands, Gwenoline Borhis
-
Patent number: 11834505Abstract: The present disclosure relates generally to antibodies and functional binding fragments thereof that bind to programmed death-ligand 1 (PD-L1). In particular, the disclosed antibodies and fragments bind to human PD-L1 and comprise novel complementary determining regions (CDRs) also disclosed herein. Finally, the present disclosure relates to administering the disclosed antibodies and fragments to subjects with cancer, thereby treating or slowing the progression or proliferation of the cancer.Type: GrantFiled: March 13, 2020Date of Patent: December 5, 2023Assignee: Checkpoint Therapeutics, Inc.Inventors: Jonathan Belk, Nathan J. Sharkey, Leonid Gorelik