Patents Examined by Iqbal Chowdhury
  • Patent number: 7435434
    Abstract: The invention relates to an S thermophilus bacterium which is resistant to attack by at least one bacteriophage, a method of production of the bacterium and a composition which comprises the bacterium. The bacterium comprises a modification of the Sfi21 prophage or the bacterial genome which disrupts expression of a gene which is essential to a bacteriophage, but not essential to the bacteria.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: October 14, 2008
    Assignee: Nestec S.A.
    Inventors: Harald Bruessow, Sacha Lucchini
  • Patent number: 7425434
    Abstract: The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to a new cyclododecanone monooxygenase and to a method of use of the cyclododecanone monooxygenase-encoding gene.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 16, 2008
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Patent number: 7419815
    Abstract: The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: September 2, 2008
    Assignee: University of Kentucky Research Foundation
    Inventors: Robert L. Houtz, Lynnette M. A. Dirk, Mark Alan Williams
  • Patent number: 7416723
    Abstract: In one embodiment, a therapeutic composition containing a pentavalent antimonial is provided. The pentavalent antimonial can be sodium stibogluconate, levamisole, ketoconazole, and pentamidine and biological equivalents of said compounds. Additionally, pentavalent antimonials that can be used in accordance with the present invention may be any such compounds which are anti-leishmaniasis agents. The therapeutic composition of this embodiment contains an effective amount of pentavalent antimonial that can be used in treating infectious diseases. The types of diseases that can be treated with the present invention include, but are not limited to, the following: diseases associated with PTPase activity, immune deficiency, cancer, infections (such as viral infections), hepatitis B, and hepatitis C. The types of cancers that the present embodiment can be used to treat include those such as lymphoma, multiple myeloma, leukemia, melanoma, prostate cancer, breast cancer, renal cancer, bladder cancer.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: August 26, 2008
    Assignee: The Cleveland Clinic Foundation
    Inventor: Taolin Yi
  • Patent number: 7413735
    Abstract: The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination technique, may be conjugated to an activated polymer to lower its immunogenecity and increase its life time. The pharmaceutical composition of the present invention exhibits an excellent inhibitory activity against angiogenesis.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 19, 2008
    Assignee: Angio Lab, Inc.
    Inventors: Bon-Hong Min, Myung-Ok Park, Min-Young Kim, Byung-Young Park, Boe-Gwun Chun, Sang-Wook Kang, Chang-Hee Moon
  • Patent number: 7410786
    Abstract: A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing polysaccharides and preparing degraded products of the polysaccharides; a genetic engineering process for producing the polypeptide; and the polypeptide obtained by the process.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: August 12, 2008
    Assignee: Takara Bio. Inc.
    Inventors: Harumi Ueno, Jun Tomono, Hiroaki Sagawa, Takeshi Sakai, Ikunoshin Kato
  • Patent number: 7393673
    Abstract: The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as Gux1. Gux1 has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified Gux1. Methods of making and using Gux1 polypeptides, including fusions, variants, and derivatives, are also disclosed.
    Type: Grant
    Filed: July 28, 2001
    Date of Patent: July 1, 2008
    Assignee: Midwest Research Institute
    Inventors: William S. Adney, Shi-You Ding, Todd B. Vinzant, Michael E. Himmel, Stephen R. Decker, Suzanne Lantz McCarter
  • Patent number: 7374921
    Abstract: Disclosed is a novel cellulase having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulase NCE5 are substituted. Further, a polynucleotide encoding the novel cellulase, an expression vector containing the polynucleotide, a host cell transformed with the expression vector, and a cellulase preparation and a washing composition containing the cellulase are disclosed. The cellulase of the present invention is resistant to surfactants, and maintains a high activity even under alkaline conditions.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: May 20, 2008
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kaoru Okakura, Koji Yanai
  • Patent number: 7371558
    Abstract: The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the cofactor requirements necessitates the use of a whole cell catalyst for an industrial process that utilizes this reaction sequence to produce 1,3-propanediol. The invention provides a microorganism with disruptions in specified genes and alterations in the expression levels of specified genes that is useful in a higher yielding process to produce 1,3-propanediol.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: May 13, 2008
    Assignees: E.I. du Pont de Nemours and Company, Genencor International
    Inventors: Marguerite A. Cervin, Phillipe Soucaille, Fernando Valle
  • Patent number: 7371554
    Abstract: It is an object of the present invention to provide isozymes of the lachrymatory factor producing enzyme, the amino acid sequences of these isozymes and a gene that codes for these amino acid sequences, and the present invention relates to three types of isozymes of the lachrymatory factor producing enzyme that contributes to the production of the lachrymatory factor that is present in onions and the like, amino acid sequences indicated by SEQ ID Nos. 1 to 3 which constitute the proteins or polypeptides of these isozymes, DNA indicated by SEQ ID Nos.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: May 13, 2008
    Assignee: House Foods Corporation
    Inventors: Shinsuke Imai, Nobuaki Tsuge, Muneaki Tomotake
  • Patent number: 7371555
    Abstract: The invention relates to isolated polypeptides having ?-H-?-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising the nucleic acids according to the invention. The invention also relates to methods of producing and using the polypeptides according to the invention. The invention also relates to a method for isolating polypeptides having ?-H-?-amino acid amide racemase activity, for isolating nucleic acids encoding the same and for isolating microorganisms comprising polypeptides having ?-H-?-amino acid amide racemase activity. The invention also relates to new microorganisms comprising polypeptides having ?-H-?-amino acid amide racemase activity.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: May 13, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Wilhelmus Hubertus Joseph Boesten, Petronella Catharina Raemakers-Franken, Theodorus Sonke, Gerrit Jan Willem Euverink, Pieter Grijpstra
  • Patent number: 7368237
    Abstract: An assay uses apoptotic nucleases to screen for apoptosis modulators, in a method of modulating apoptosis, and in a method of aiding in a diagnosis of a disease, among other methods. materials for use in the assay include isolated or recombinant polypeptides and polynucleotides, compositions comprising those isolated or recombinant polypeptides and polynucleotides, vectors, transgenic organisms, and integrated systems among other aspects.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: May 6, 2008
    Inventors: Jay Parrish, Ding Xue
  • Patent number: 7364883
    Abstract: The present invention is directed to a process of producing novel fatty acids in oleaginous yeast by producing oleaginous yeast by introducing into the yeast genes coding for enzymes selected from the group consisting of D5-desaturase, D6-desaturase, D12-desaturase, D15-desaturase and elongase; and culturing the yeast in the medium containing high levels of carbon sources. The present invention is further directed to a residue or fatty acid that is obtained from pressing the oleaginous yeast produced by the process of the invention.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: April 29, 2008
    Assignee: Yeastern BioTech Co., Ltd.
    Inventor: Tzu-Chih Chen
  • Patent number: 7364889
    Abstract: A catalytically active peptide comprising an imidazole function in position i flanked by at least one functional group to be amidated in position i+3+4k, where k is an integer equal to or higher than ?1 or in position i?4?4n, wherein n is an integer equal to or higher than 0, characterized in that it also comprises at least one activating group in position i+4+4n or i?3?4n, respectively, wherein n is as above.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: April 29, 2008
    Assignee: Modpro AB
    Inventor: Lars Baltzer
  • Patent number: 7354741
    Abstract: A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human chondroitin synthase, it is possible to produce a saccharide chain having a repeating disaccharide unit of chondroitin. The DNA or part thereof may be used as a probe for hybridization for the human chondroitin synthase.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: April 8, 2008
    Assignee: Otsuka Chemical Co., Ltd.
    Inventors: Kazuyuki Sugahara, Hiroshi Kitagawa
  • Patent number: 7351542
    Abstract: The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: April 1, 2008
    Assignee: The Regents of the University of California
    Inventors: Eric M. Verdin, Brian J. North, Scott M. Ulrich
  • Patent number: 7348172
    Abstract: The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a catalytic module (CAT) and a carbohydrate binding module (CBM) separated by a linker region. The DNA construct comprising a truncated actinomycetes, preferably Nonomuraea flexuosa (NJ) derived DNA sequence encoding a truncated form of the CD enzyme, for example Nf Xyn11A, Nf Xyn10A, and is introduced into a filamentous fungal host. Said CD enzyme contains the catalytically active region of CAT but lacks part or all of the CBM, or all of the CBM and part or all of the linker region and is expressed and secreted under the control of regulatory sequences comprising at least a signal sequence, but also promoters, terminators and DNA sequences encoding a secretable carrier protein or domains thereof, preferably originating from filamentous fungi are included.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: March 25, 2008
    Assignee: AB Enzymes Oy
    Inventors: Marja Paloheimo, Arja Mantyla, Sanna Leskinen, Richard Fagerstrom, Jarno Kallio, Terhi Puranen, Raija Lantto, Pirkko Suominen
  • Patent number: 7348168
    Abstract: The present invention relates to polypeptides having cellobiohydrolase II activity and polynucleotides having a nucleotide sequence, which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: March 25, 2008
    Assignee: Novozymes A/S
    Inventors: Wenping Wu, Lene Lange, Dominique Aubert Skovlund, Ye Liu
  • Patent number: 7341859
    Abstract: The present invention relates to an alcohol dehydrogenase from Rhodococcus erythropolis. By means of such cofactor-dependent ADHs, chiral alcohols, which can be of use for use in organic syntheses, can advantageously be obtained with a cofactor-regenerating enzyme in a coupled enzymatic system. A nucleotide sequence, vehicles containing this, a polypeptide sequence and processes for mutation and use of the sequences are claimed.
    Type: Grant
    Filed: April 1, 2003
    Date of Patent: March 11, 2008
    Assignee: Degussa AG
    Inventors: Werner Hummel, Kofi Abokitse, Harald Groeger
  • Patent number: 7338776
    Abstract: A purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its productions of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination of UDPG in a sample. The one-way enzyme protein catalyses hydrolysis of UDP-glucose, the precursor molecule of glycogen, into glucose-1-phosphate (G1P) and uridine 5?-monophosphate (UMP).
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: March 4, 2008
    Assignees: JCR Pharmaceuticals Co., Ltd., Universidad Publica De Navarra Campus Arrosadia
    Inventors: Javier Pozueta Romero, Edurne Baroja Fernandez, Francisco Jose Munoz, Imbak Shu, Ryuji Yamamoto