Patents Examined by Irem Ycel
  • Senescence responsive transcriptional element
    Patent number: 5965543
    Abstract: Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: October 12, 1999
    Assignee: Geron Corporation
    Inventors: Judith Campisi, Alessandro Testori