Patents Examined by Irina Neagu
  • 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]--ethyl-hept-5-enamide (bimatoprost) in crystalline form II, methods for preparation, and methods for use thereof
    Patent number: 9181176
    Abstract: The present invention provides a new crystalline form of bimatoprost, designated as crystalline form II. This new crystalline form is the most stable form known to date of bimatoprost. Moreover, it has been found that bimatoprost crystalline form II is readily prepared from crystalline form I.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: November 10, 2015
    Assignee: Allergan, Inc.
    Inventors: Gyorgy F. Ambrus, Thomas K. Karami, Ke Wu
  • Inhibitors of PDE4 enzyme and antagonists of muscarinic M3 receptor
    Patent number: 9169245
    Abstract: Compounds of formula (I) described herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: October 27, 2015
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Mauro Riccaboni, Charles Baker-Glenn
  • Oxazoline and isoxazoline derivatives as CRAC modulators
    Patent number: 9169242
    Abstract: The present invention relates to compounds that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC and to processes for preparing these compounds. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC by these compounds.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: October 27, 2015
    Assignee: LUPIN LIMITED
    Inventors: Nageswara Rao Irlapati, Gokul Keruji Deshmukh, Vijay Pandurang Karche, Santosh Madhukar Jachak, Neelima Sinha, Venkata P. Palle, Rajender Kumar Kamboj
  • Coelenterazine analogs and manufacturing method thereof
    Patent number: 9151739
    Abstract: There has been a need for coelenterazine analogs that exhibit luminescence properties different from those of known coelenterazine analogs. The present invention provides the compound represented by general formula (1).
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: October 6, 2015
    Assignees: JNC CORPORATION, TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Satoshi Inouye, Yuiko Sahara, Rie Iimori, Takamitsu Hosoya
  • Compositions and methods for stimulating hair growth
    Patent number: 9149484
    Abstract: Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: October 6, 2015
    Assignee: Allergan, Inc.
    Inventors: Kevin S. Warner, Kristin B. Prinn, Chetan P. Pujara, Pramod Sarpotdar, John T. Trogden, Adnan K. Salameh, Guang Wei Lu
  • Compositions and methods for stimulating hair growth
    Patent number: 9138480
    Abstract: Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R1 and R2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: September 22, 2015
    Assignee: Allergan, Inc.
    Inventors: John T. Trogden, Adnan K. Salameh, Chetan P. Pujara
  • Pyrimidine substituted purine compounds as kinase (S) inhibitors
    Patent number: 9138437
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: September 22, 2015
    Assignee: Verastem, Inc.
    Inventors: DiZhong Chen, Meredith Williams
  • Treatment of prostate carcinoma
    Patent number: 9132105
    Abstract: Disclosed herein are naphthoquinone analogs, such as plumbagin, pharmaceutical compositions that include naphthoquinone analogs, such as plumbagin, and methods of treating diseases and/or conditions such as cancer with naphthoquinone analogs, such as plumbagin. Also included are combination therapies wherein a naphthoquinone analog, such as plumbagin, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: September 15, 2015
    Assignee: Pellficure Pharmaceuticals, Inc.
    Inventor: Per Borgström
  • Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
    Patent number: 9131680
    Abstract: Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: September 15, 2015
    Assignee: NanoBio Corporation
    Inventors: Theodore C. Annis, James R. Baker, Tarek Hamouda
  • Compositions and methods relating to resveratrol
    Patent number: 9125858
    Abstract: The present invention relates to compositions and methods comprising resveratrol and uses thereof. Some embodiments include compositions and methods with increased bioavailability of resveratrol. Certain embodiments include compositions comprising resveratrol and a solubilizer. Particular embodiments include transmucosal delivery of resveratrol from the composition.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: September 8, 2015
    Assignee: WILMORE LABS L.L.C.
    Inventors: Otis L. Blanchard, Tina C. Blanchard
  • Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase
    Patent number: 9115127
    Abstract: Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: August 25, 2015
    Assignee: AMGEN INC.
    Inventors: Christiane M. Boezio, Alan C. Cheng, Deborah Choquette, Richard T. Lewis, Michele H. Potashman, Karina Romero, John C. Stellwagen, Douglas A. Whittington
  • Aryl sultam derivatives as RORc modulators
    Patent number: 9115101
    Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: August 25, 2015
    Assignee: Genentech, Inc.
    Inventors: Monique Bodil van Niel, Benjamin Fauber, Simon Gaines, Alberto Gobbi, Olivier Rene, David Vesey, Stuart Ward
  • Nicotinamides as JAK kinase modulators
    Patent number: 9102625
    Abstract: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: August 11, 2015
    Assignee: PORTOLA PHARMACEUTICALS, INC.
    Inventors: Shawn M. Bauer, Yonghong Song, Qing Xu, Jack W. Rose, Zhaozhong J. Jia, Brian Kane, Wolin Huang, Anjali Pandey, Mukund Mehrotra
  • Methods and compositions for treating metabolic syndrome
    Patent number: 9089579
    Abstract: Provided are methods, compositions, systems, and kits for treating metabolic syndrome or a disorder associated with metabolic syndrome, e.g., obesity, dyslipidemia, and/or a diabetic condition, comprising administering systemically to a subject one or more compounds of the Formula (I) and/or (II): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein, L, R1; R2, Z, X, A and B are defined herein.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: July 28, 2015
    Assignee: Topokine Therapeutics, Inc.
    Inventor: Murat V. Kalayoglu
  • Process for the preparation of a pharmaceutical composition comprising ezetimibe
    Patent number: 9089486
    Abstract: The present invention belongs to the field of pharmaceutical industry and relates to a process for preparing dosage forms containing ezetimibe, comprising the steps of: a) providing a composition comprising ezetimibe, b) sieving a composition comprising a composition of step (a), c) shear mixing of the composition after step (b), preferably the mixing of the composition is carried out by high shear mixing, d) formulation into a dosage form. The present invention also relates to dosage forms containing ezetimibe and ezetimibe and simvastatin, which have been prepared according to the process according to the invention.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: July 28, 2015
    Assignee: LEK PHARMACEUTICALS D.D.
    Inventors: Janez Kerc, Miha Homar, Polona Jurkovic
  • Hydroxylated tricyclic compounds
    Patent number: 9090535
    Abstract: The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the small molecule drug not attached to the water-soluble oligomer.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: July 28, 2015
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Bo-Liang Deng, Hema Gursahani
  • Pest control agent
    Patent number: 9073866
    Abstract: Specific amine derivatives have been found to possess excellent activities as pest control agents.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: July 7, 2015
    Assignee: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shinzo Kagabu, Masaaki Mitomi, Shigeki Kitsuda, Ryo Horikoshi, Masahiro Nomura, Yasumichi Onozaki
  • Phenicol antibacterials
    Patent number: 9073894
    Abstract: The present invention provides novel phenicol derivatives of formula I their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: July 7, 2015
    Assignee: Zoetis Services LLC
    Inventors: Richard A. Ewin, Timothy Allan Johnson, Susan M. K. Sheehan
  • Alprostadil and dyclonine for treatment of premature ejaculation
    Patent number: 9066854
    Abstract: Compositions and methods for the treatment of premature ejaculation are provided wherein a composition comprising a topical anesthetic, a shear-thinning polymeric thickener, a lipophilic component that is selected from the group consisting of an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, a liquid polyol and a mixture thereof, water and a buffer system that provides a buffered pH value for the composition in the range of about 3 to about 7.4 is administered to the penile meatus.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: June 30, 2015
    Assignee: NEXMED HOLDINGS, INC.
    Inventors: Mingqi Lu, Qin Wang, James L. Yeager, Y. Joseph Mo
  • Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone
    Patent number: 9060967
    Abstract: An aqueous pharmaceutical solution composition comprising between about 20 mg/ml to about 100 mg/ml of a radioprotective ?,?-unsaturated aryl sulfone, a cosolvent comprising polyethylene glycol (PEG), polypropylene glycol, polyglycerol, DMA, propylene glycol, glycerol, ethanol, sorbitol, isopropyl alcohol, or a combination thereof in an amount between about 25% and about 90% w/v, and a water soluble Vitamin E derivative, wherein the composition has a pH within the range of about 7.0 to about 9.5.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: June 23, 2015
    Assignee: ONCONOVA THERAPEUTICS, INC
    Inventor: Manoj Maniar