Patents Examined by Isaac Shomer
  • Patent number: 12005132
    Abstract: This invention proposes a multifunctional topical composition that integrates halogen-functionalized fullerenes and metallic nanoparticles (NPs) to provide comprehensive skin protection and sanitizing, cosmetic enhancement, and in some embodiments, treatment for various conditions. Leveraging the atomic scale and physical characteristics of halogenated fullerenes for deeper tissue dispersion, the composition can provide antioxidant, antimicrobial, and UV protective benefits to foster cellular integrity, proliferation, and differentiation as healthy tissue. The proposed formulation can deliver active ingredients through the pores of sweat glands; the lipid matrix of the stratum corneum; and hair follicles, sebaceous glands, and pilosebaceous pores to then penetrate underlying dermal layers. This composition also uses stable, inorganic antibacterial agents with a robust safety profile.
    Type: Grant
    Filed: August 11, 2023
    Date of Patent: June 11, 2024
    Inventors: Terry Earl Brady, Anthony Lee Dellinger, Lowell Hughes, Lori Bush, Melinda K. M. Goddard, Abed Algader Ibrahim
  • Patent number: 11998520
    Abstract: The present disclosures provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: June 4, 2024
    Assignee: The United States Government as Represented by the Department of Veterans Affairs
    Inventor: Guy Weinberg
  • Patent number: 11998616
    Abstract: The present application discloses nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands suitable for delivering these therapeutic agents through the blood brain barrier and methods of using these patients on those patients in need of such treatment.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: June 4, 2024
    Assignee: California Institute of Technology
    Inventors: Mark E. Davis, Emily A. Wyent
  • Patent number: 11986551
    Abstract: A toothpaste product that is laced with, or infused with, a sedative such as the active ingredients in cannabis. The act of brushing one's teeth using the present invention transfers the sedative into the bloodstream through contact with the gums, leading to a more restful sleep.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: May 21, 2024
    Inventors: Daniel S. Nam, Eugene Kwon
  • Patent number: 11981571
    Abstract: In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (┬ĚC) density.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: May 14, 2024
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NORTHWESTERN UNIVERSITY
    Inventors: Andre E. Nel, Tian Xia, Ruibin Li, Mark C. Hersam, Nikhita D. Mansukhani, Linda Guiney
  • Patent number: 11980673
    Abstract: Lipid-based vesicles, typically herein called transfection competent vesicles (TCVs), configured to safely and efficiently deliver DNA, RNA, other nucleic acid and protein cargoes into target cells. The safety and efficiency are each, and both, achieved in part by eliminating organic solvents such as ethanol and detergents such as sodium dodecyl sulfate from the TCV loading processes (i.e., inserting a cargo into the TCV), TCV storage processes, and/or TCV delivery processes. The cargoes can also comprise nucleic acids complexed with a protein, such as a ribonucleoprotein (RNP). The systems, compositions, devices and methods, etc., herein, in some embodiments, can provide empty TCVs that can if desired be loaded at the bench without use of specialized equipment.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: May 14, 2024
    Assignee: The University of British Columbia
    Inventors: Blair Leavitt, Pieter Cullis, Terri Petkau, Austin Hill, Pamela Wagner, Jayesh Kulkarni
  • Patent number: 11980688
    Abstract: Provided are a nanoliposome-microbubble conjugate in which a drug for hair loss treatment such as finasteride, minoxidil, dutasteride, etc. is encapsulated in a nanoliposome and a composition for alleviating or treating hair loss containing the same. Since an orally administered agent such as finasteride, currently useful as a drug for hair loss treatment, causes side effects, drug delivery through scalp application is most desirable, but the drug is not delivered to hair follicle cells through scalp application alone. Since a drug for hair loss treatment useful as an external preparation for skin causes various side effects, the concentration thereof that is used needs to be further lowered. The above nanoliposome-microbubble conjugate is capable of increasing the delivery efficiency of a drug for hair loss treatment at a low concentration, and is thus very effective at treating androgenic alopecia.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: May 14, 2024
    Assignee: MOOGENE MEDI CO., LTD.
    Inventor: Kyeong Nam Yu
  • Patent number: 11975077
    Abstract: A cell-penetrating peptide (CPP) comprising a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: May 7, 2024
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventor: Joong Ho Moon
  • Patent number: 11964051
    Abstract: Disclosed are cationic lipids which are compounds of Formula (I?). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: April 23, 2024
    Assignee: TRANSLATE BIO, INC.
    Inventors: Frank DeRosa, Shrirang Karve, Yi Zhang, Michael Heartlein
  • Patent number: 11964058
    Abstract: A process can be used for preparing nanoparticles containing at least one bio-resorbable polyester. The nanoparticles are in the form of a powder with a Z-Average particle size Dz in the range of 1 to 450 nm, and with a polydispersity index PDI in the range of 0.01 to 0.5. The process involves emulsion-solvent extraction or emulsion-solvent evaporation, and application of ultrasonic sound.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: April 23, 2024
    Assignee: Evonik Corporation
    Inventors: David Fecher, Maria Camilla Operti, Rima Jaber, Andrea Engel, Silko Grimm, Min Yang
  • Patent number: 11957794
    Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: April 16, 2024
    Assignees: Albert-Ludwigs-Universitaet Freiburg, Queen Mary University of London
    Inventors: Gleb Sukhorukov, Irina Nazarenko, Yana Tarakanchikova, Toni Cathomen, Tatjana Cornu, Valentina Pennucci, Jamal Alzubi
  • Patent number: 11957709
    Abstract: The present disclosure relates to a nanoemulsion composition of oxygen gas sustained release and method for preparing the same, and provides a nanoemulsion composition of oxygen gas sustained release and method for preparing the same, including a water phase part containing water, and an oil phase part dispersed in the water phase part and made of nanoparticle containing a perfluorocarbon compound, wherein the oil phase part contains oxygen gas, and the oxygen gas is released in sustained release. According to the present disclosure, there are advantages of preventing hair loss or promoting hair growth by increasing the amount of oxygen gas supplied to the hair bulb and the oxygen release time from the hair bulb.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: April 16, 2024
    Assignees: AMOREPACIFIC CORPORATION, CHOSUN NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Phil June Park, Jun-pil Jee, Bongsoo Pi, Haewon Jeong, Hyoung June Kim, Dalsu Na, Wonseok Park
  • Patent number: 11957785
    Abstract: An orally administered dosage form that facilitates delivery of an agent locally in the buccal cavity for a sustained period of time includes mucoadhesive particles that are made of at least a mucoadhesive material combined with the agent, and which are dispersed in a disintegrating film. The dosage form is capable of delivering an agent to a patient at the desired oral mucosa site over an extended period of time while reducing patient discomfort or annoyance associated with conventional sustained release mucoadhesive films that must reside on the oral mucosa during the period of sustained release.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: April 16, 2024
    Assignee: Intelgenx Corp.
    Inventors: Rodolphe Obeid, Nadine Paiement, Erick Gonzalez-Labrada
  • Patent number: 11951210
    Abstract: This application is directed to methods which allow for encapsulation of an array of biological materials under physiological conditions that are relevant given a biological context and the compositions made using those methods. These reconstituted biological materials encompass: a) purified proteins that can bind to the lipid membranes inside and outside of vesicles based on the electrostatic charge; b) purified cytosolic proteins that position themselves in the lumen of the vesicles, c) mammalian cell extracts with an array of cytosolic protein content, among other contents and d) small biological molecules such as DNA and RNA as well as fluorescent dyes/probes. These vesicles can be used to simulate cells in drug discovery methods as well as useful in administering drugs and other compositions to cells in vitro and in vivo.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: April 9, 2024
    Assignee: THE JOHNS HOPKINS UNIVERSTY
    Inventors: Shiva Razavi, Takanari Inoue, Tianzhi Luo, Douglas Robinson
  • Patent number: 11951211
    Abstract: A method for producing uniform-size liposomes is provided. The liposomes are coated with a sorting agent to yield a plurality of density-modified liposomes of different sizes. These liposomes are then separated using a densitometric method. The sorting agent includes both a density-modifying moiety and a targeting moiety.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: April 9, 2024
    Assignee: YALE UNIVERSITY
    Inventors: Chenxiang Lin, Yang Yang
  • Patent number: 11944604
    Abstract: A spirooxindole nanoformulation includes a proniosome loaded with a spirooxindole derivative.
    Type: Grant
    Filed: March 10, 2023
    Date of Patent: April 2, 2024
    Assignee: KING SAUD UNIVERSITY
    Inventors: Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al Majid, Yaseen Ali Mosa Mohamed Elshaier, Eman Ahmed Ibrahim Mazyed, Farid A. Badria
  • Patent number: 11944705
    Abstract: Provided are a nanoliposome-microbubble conjugate in which a drug for hair loss treatment such as finasteride, minoxidil, dutasteride, etc. is encapsulated in a nanoliposome and a composition for alleviating or treating hair loss containing the same. Since an orally administered agent such as finasteride, currently useful as a drug for hair loss treatment, causes side effects, drug delivery through scalp application is most desirable, but the drug is not delivered to hair follicle cells through scalp application alone. Since a drug for hair loss treatment useful as an external preparation for skin causes various side effects, the concentration thereof that is used needs to be further lowered. The above nanoliposome-microbubble conjugate is capable of increasing the delivery efficiency of a drug for hair loss treatment at a low concentration, and is thus very effective at treating androgenic alopecia.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: April 2, 2024
    Assignee: MOOGENE MEDI CO., LTD.
    Inventor: Kyeong Nam Yu
  • Patent number: 11918652
    Abstract: An acoustic wave medical treatment of a body part of an individual in which nanoparticles are administered to the body part of the individual and the acoustic wave is applied on the body part. The acoustic wave is sequentially applied on the body part, and/or the nanoparticles are magnetosomes. Also, compositions that include these nanoparticles.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: March 5, 2024
    Assignee: NANOBACTERIE
    Inventor: Edouard Alphandery
  • Patent number: 11896712
    Abstract: The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The invention also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: February 13, 2024
    Assignee: Versantis AG
    Inventors: Jean-Christophe Leroux, Vincent Forster
  • Patent number: 11872313
    Abstract: The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: January 16, 2024
    Inventors: Gregory M. Lanza, Dipanjan Pan