Patents Examined by Isaac Shomer
  • Patent number: 11026881
    Abstract: A toothpaste product that is laced with, or infused with, a sedative such as the active ingredients in cannabis. The act of brushing one's teeth using the present invention transfers the sedative into the bloodstream through contact with the gums, leading to a more restful sleep.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: June 8, 2021
    Inventors: Daniel S. Nam, Eugene Kwon
  • Patent number: 11007161
    Abstract: The present invention provides nanoparticle dispersion for topical delivery to skin of a mammal. The nanoparticle dispersion includes: a sorbitan ester surfactant; one or more poly(ethoxylate) surfactants, one or more lipids; and ibuprofen. Methods of preparing various water continuous dispersion of nanoparticles are also provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: May 18, 2021
    Inventor: Eric Morrison
  • Patent number: 11000478
    Abstract: Provided herein is technology relating to incorporation of drugs into liposomes and particularly, but not exclusively, to methods for incorporating drugs into liposomes using a weak base and related compositions.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 11, 2021
    Inventors: Timothy D. Heath, Lisa Ann Krugner-Higby, Amy Lautenbach
  • Patent number: 11000472
    Abstract: The present invention relates to a system for administering a poorly-soluble compound to the skin, the system being capable of exerting an excellent effect by stably impregnating the poorly-soluble compound and effectively delivering the poorly-soluble compound into the skin, and the present invention is technically characterized by a microneedle to which microparticles comprising a poorly-soluble compound are added. In addition, the present invention provides a method for administering a poorly-soluble compound to the skin, the method being characterized by using the microneedle.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: May 11, 2021
    Inventors: Woo-Sun Shim, Sun-Hwa Lee, Young-Min Hwang, Jung-A Kim, Nae-Gyu Kang
  • Patent number: 10993919
    Abstract: Compositions and methods are disclosed herein to deliver and anchor nanoscale drug carriers into the extracellular matrix (ECM) of tissues, such as degenerating cartilage or tumor margins, and to provide local and sustained release of drugs.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 4, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Blanka Sharma, Shannon B. Brown
  • Patent number: 10993914
    Abstract: Irinotecan phospholipid liposomes with improved storage stability are provided, with related methods of treatment and manufacture. The irinotecan liposomes can have reduced formation of lyso-phosphatidylcholine (lyso-PC) during storage, and prior to administration to a patient.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 4, 2021
    Inventors: Daryl C. Drummond, Dmitri B. Kirpotin, Mark Eamon Hayes, Charles Noble, Kevin Kesper, Antoine M. Awad, Douglas J. Moore, Andrew J. O'Brien
  • Patent number: 10980796
    Abstract: The present invention relates to a drug delivery system having a double core-shell structure and, specifically, to a double nano-drug delivery system having an inner core-shell containing a poorly soluble camptothecin compound and a water-soluble camptothecin compound inside and an amphiphilic polymer shell, and to a manufacturing method therefor. The double core-shell structured particles manufactured by the present invention form very stable particles and show a mono-distribution of particles before and after freeze-drying. The particles of the present invention show excellent results compared with existing monolayer micelles in animal efficacy tests and pharmacokinetic tests, and do not use a surfactant causing hypersensitivity, and thus the use of the particles of the present invention can provide a pharmaceutical composition or a drug delivery system platform, which are safe for the human body.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: April 20, 2021
    Assignee: SN BIOSCIENCE INC.
    Inventors: Young Hwan Park, Il Hyun Lee
  • Patent number: 10955410
    Abstract: A coating agent for preventing the adsorption of extracellular vesicles represented by exosomes to a tool has been developed. Adsorption of extracellular vesicles to a tool can be prevented by using a coating agent which contains a hydrophilic polymer having a weight average molecular weight of 10,000 or more and 1,000,000 or less, wherein a coated layer formed by the coating agent has a contact angle of 0 degree or more and 30 degrees or less.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 23, 2021
    Inventors: Kiyotaka Shiba, Nobuyuki Sakamoto, Tomozumi Noda, Satoshi Yamada
  • Patent number: 10946029
    Abstract: Compositions comprising a corticosteroid and a beta-adrenergic are useful for treating inflammatory or obstructive airways diseases.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: March 16, 2021
    Inventors: Elisa Monari, Anna Maria Cantarelli, Daniela Cocconi, Irene Pasquali
  • Patent number: 10933026
    Abstract: A method of manufacturing a therapeutic agent for the treatment of infections includes the steps of preparing a homogeneous solution of poly(DL-lactide-co-glycolide acid), preparing a solution of a peroxygen donor, preparing a solution of an acetyl donor, adding each of the solutions to a quantity of the poly(DL-lactide-co-glycolide acid) solution to produce a resultant mixture, preparing encapsulated nano- or micro-scale particles from the resultant mixture using a microencapsulator, collecting the nano- or micro-scale particles, and subsequently subjecting the particles to a lyophilization process.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: March 2, 2021
    Inventor: Adrian Neville Fellows
  • Patent number: 10934168
    Abstract: The present invention relates to a bioactive or real-time and pathogen killing material comprised of a carbon nanostructure (preferably a fullerene but including other functionalized carbon-based nanostructures) that possess potent broad-spectrum antimicrobial properties. The present invention relates to the utilization of functionalized carbon nanostructures as a bioactive antimicrobial substance that is incorporated into a material, including a textile, fabric, solution, salve, or cream. The preferred embodiment of the present invention is fullerene derivatives that are chemically functionalized on the cage with a halogen element. The present invention pertains to a material that is suitable for barrier garments, accessory garments (shoe covers, masks, facial visors, etc.), textiles (bed sheets, blankets, towels, personal clothing, gowns, surgical drapes, curtains, drapes, pads, etc.), filtration matrices (for use in hemodialysis, hemofiltration, etc.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: March 2, 2021
    Inventors: Terry Earl Brady, Anthony Lee Dellinger, Arnie Lee Robertson, Jr., Rachel Tinker-Kulberg
  • Patent number: 10933027
    Abstract: The present invention relates to a construct including a porous core, a cargo, and a spacer disposed between the core and the cargo. In some examples, the construct further includes an outer layer composed of a lipid, a polymer, or a combination thereof. Methods of making and employing such constructs are also described herein.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: March 2, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Darryl Y. Sasaki, Oscar Negrete, Edwin A. Saada, Patrick F. Fleig, Scott Reed, Eric L. Qiao
  • Patent number: 10918577
    Abstract: A dental treatment material includes: a liquid dispersion of a glass powder; and an inorganic phosphoric acid aqueous solution, wherein the glass powder contains zinc, silicon, and fluorine and does not substantially contain aluminum.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: February 16, 2021
    Assignee: GC Corporation
    Inventors: Ryosuke Yoshimitsu, Satomi Tateiwa, Katsushi Yamamoto, Syouichi Fukushima
  • Patent number: 10920084
    Abstract: Aqueous dispersion containing a hydrophilic metal oxide powder comprising a metal oxide and a surface modification of the metal oxide, wherein a) the metal oxide is selected from the group consisting of TiO2, ZrO2, SiO2, Al2O3, Fe2O3, Fe3O4, Sb2O3, WO3, CeO2 and mixed oxides thereof and b) the surface modification b1) comprises silicon atoms and aluminum atoms and b2) the silicon atoms are at least partly bonded to a hydrocarbon radical via a C atom and b3) the Al/Si molar ratio of the surface modification is 1:2-1:20.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: February 16, 2021
    Inventors: Wolfgang Lortz, Ulrich Fischer, Daniel Ness, Gabriele Bergmann, Katharina Dauth
  • Patent number: 10914734
    Abstract: Compositions which comprise a gold nanoparticle, dithiolated diethylenetriamine pentaacetic acid (DTDTPA), and a thioctic acid terminated peptide, wherein the DTDTPA is directly linked to the gold nanoparticle surface via an Au—S bond, and wherein the thioctic acid terminated peptide is directly linked to the gold nanoparticle surface via an Au—S bond.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: February 9, 2021
    Assignee: The Curators of the University of Missouri
    Inventors: Raghuraman Kannan, Ajit Zambre, Anandhi Upendran
  • Patent number: 10898435
    Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: January 26, 2021
    Assignee: FUJIFILM Corporation
    Inventors: Makoto Ono, Kohei Ono, Takeshi Matsumoto, Mikinaga Mori
  • Patent number: 10895620
    Abstract: Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129Xe MRI RBC image.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: January 19, 2021
    Assignee: Duke University
    Inventors: Bastiaan Driehuys, Gary Price Cofer
  • Patent number: 10888572
    Abstract: A hydrated lecithin carrier vesicle composition includes lecithin and a triglyceride source or fatty acid in conditioned water. The disclosed compositions may be used for controlling appetite, weight loss, modulating effects from alcohol consumption, and/or delivering active agents to the small intestine.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: January 12, 2021
    Inventors: Donald F. Hodgson, Crispin G. S. Eley
  • Patent number: 10881620
    Abstract: The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non-physiological conditions, through unfolding and loss of secondary and/or higher order structure.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: January 5, 2021
    Inventors: Asel Sartbaeva, Stephen Wells
  • Patent number: 10857198
    Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonarychronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: December 8, 2020
    Inventors: Martin Knoch, Oliver Denk