Patents Examined by Isaac Shomer
  • Plant medium including an oxygen-enabled composition
    Patent number: 11458161
    Abstract: A composition including a plant medium and a poly-oxygenated metal hydroxide that comprises a clathrate containing oxygen gas molecules. The poly-oxygenated metal hydroxide may comprise of a poly-oxygenated aluminum hydroxide. The composition may include one or more nutrients. The composition may be in a solid form, a fluid form, or a combination thereof. The poly-oxygenated aluminum hydroxide is soluble in a fluid. In one embodiment, the poly-oxygenated metal hydroxide composition may have particles having a diameter of 212 ?m or less, and which may be homogeneous.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: October 4, 2022
    Assignee: HEMOTEK, LLC
    Inventors: Caree L. Woodmansee, Robert A. Woodmansee, John W. Woodmansee, Jr., William E. Harmon
  • Tissue stain and use thereof
    Patent number: 11452783
    Abstract: Provided is a tissue staining composition containing carbon particles having a mean particle diameter less than 0.3 ?m in diameter (optionally less than 0.2 ?m in diameter) together with one or more agents that maintain the carbon particles in suspension (for example, an anti-settling agent and/or surfactant). In certain circumstances, the anti-settling agent may also have mucoadhesive properties. The tissue staining composition is visually dark and does not disperse rapidly when introduced into regions of tissue of interest making it ideal for marking the regions that can be visualized clearly and over prolonged periods of time via, for example, direct visualization, endoscopic or laparoscopic inspection. The invention also provides methods of making and using the tissue staining composition for marking regions of tissue of interest, for example, gastrointestinal tissue, as well as other tissues.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: September 27, 2022
    Assignee: GI SUPPLY
    Inventors: Mary Jo Timm, Robert G. Whalen, Amy A. Cameron, Patrick Lee
  • Systems and methods for improved delivery of osteoinductive molecules in bone repair
    Patent number: 11452760
    Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: September 27, 2022
    Assignee: BIOVENTUS, LLC
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
  • Implant with reactive oxygen species scavenging coating
    Patent number: 11426495
    Abstract: A chronically implanted medical device is disclosed that has an outermost layer formed from a conjugate of a polymer with lipoic acid, the conjugate having free 1,2-dithiolane groups. It is contemplated that this layer scavenges reactive oxygen species, i.e. acts as an antioxidant, and thus reduces inflammation and other adverse effects around the implant itself.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: August 30, 2022
    Assignee: Battelle Memorial Institute
    Inventors: Gaurav Sharma, Ramanathan S. Lalgudi, Chad E. Bouton
  • Freeze-dried product and gas-filled microvesicles suspension
    Patent number: 11426352
    Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: August 30, 2022
    Assignee: BRACCO SUISSE SA
    Inventors: Philippe Bussat, Anne Lassus, Jean Brochot, Michel Schneider, Feng Yan
  • Method for producing sieved low-substituted hydroxypropyl cellulose
    Patent number: 11421043
    Abstract: There is provides a method for producing sieved low-substituted hydroxypropyl cellulose (L-HPC) at improved yield, while maintaining flowability and tablet properties. More specifically, there is provided a method for producing sieved L-HPC including a first sieving step of sieving L-HPC having a hydroxypropoxy group content of 5 to 16% by mass with a sieving shaker with horizontal movement of a sieve surface to obtain first sieve-residual L-HPC and first sieve-passed L-HPC, a second sieving step of sieving the first sieve-residual L-HPC with a sieving shaker with vertical movement of a sieve surface to obtain second sieve-residual L-HPC and second sieve-passed L-HPC, and a step of combining the first sieve-passed L-HPC and the second sieve-residual L-HPC to obtain the sieved L-HPC.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: August 23, 2022
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Kentaro Miki, Akiko Tsuchida, Akira Kitamura, Yasuyuki Hirama
  • Prebiotic oral care methods using a saccharide
    Patent number: 11419806
    Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: August 23, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Hans Stettler, Wim Teughels, Marc Quirynen, Nico Boon
  • Multi-phase oral care compositions
    Patent number: 11413127
    Abstract: Semisolid oral dispersions for whitening teeth including hydrogen peroxide adducts in petrolatum. The hydrogen peroxide adduct can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The semisolid oral dispersion and/or the petrolatum can have a cone penetration consistency value of from about 25 to about 300.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: August 16, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Paul Albert Sagel, Jayanth Rajaiah, Michael David Curtis
  • Preparation and storage of liposomal RNA formulations suitable for therapy
    Patent number: 11395799
    Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 26, 2022
    Assignee: BioNTech SE
    Inventors: Heinrich Haas, Sebastian Hörner, Isaac Hernan Esparza Borquez, Thomas Michael Hiller, Ferdia Bates
  • Bioerodible cross-linked hydrogel implants and related methods of use
    Patent number: 11383006
    Abstract: The present disclosure is directed to a composite implant for the sustained release of a therapeutic agent from a hydrogel matrix. The hydrogel matrix may be a cross-linked bioerodible polyethylene glycol (PEG) hydrogel with a therapeutic complex dispersed within the cross-linked bioerodible PEG hydrogel. The therapeutic complex may include a therapeutic agent in association with mesoporous silica particles. The composite implant is configured to be delivered to or implanted into an eye of a subject or patient. The composite implant may be used treat ocular disease in a subject or patient. Ocular diseases may be selected from at least one of neovascular age related macular degeneration (AMD), diabetic macular edema, or macular edema following retinal vein occlusion.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: July 12, 2022
    Assignee: DOSE MEDICAL CORPORATION
    Inventors: Patrick Michael Hughes, Ina Mustafaj
  • Sting activating nanovaccine for immunotherapy
    Patent number: 11376324
    Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: July 5, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jinming Gao, Zhijian Chen, Min Luo, Zhaohui Wang, Hua Wang, Haocheng Cai, Gang Huang, Yang-Xin Fu
  • Biodegradable polymer microparticle containing steroid drug and preparation method therefor
    Patent number: 11376226
    Abstract: Biodegradable polymer microparticles bearing a steroid drug and a preparation method therefor. In the method, a steroid drug and a biodegradable polyester-based polymer are dissolved in an organic solvent and sprayed into a low-temperature hydrocarbon solution to form frozen microparticles that are then immersed in a low-temperature, aqueous salt solution to deprive the microparticles of the organic solvent, thereby preparing biodegradable polymer microparticles bearing a steroid drug. The steroid drug or steroid sex hormone drug-bearing biodegradable polymer microparticles were found to have excellent biocompatibility, biodegradability, porosity, and mechanical strength and to release the steroid drug or steroid sex hormone drug for a long period of time.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: July 5, 2022
    Assignee: REGENBIOTECH, INC.
    Inventors: Jeoung Yong Kim, Won Chun Lee, Mi Yeon Kang, Hang Je Choi
  • Detoxification using nanoparticles
    Patent number: 11357736
    Abstract: The present invention relates treatments of a toxin in a subject. The toxin at least partially effects its toxicity in the subject via binding to a target cell of the subject. The present invention provides for methods, combinations and pharmaceutical compositions for decreasing or neutralizing the effect of a toxin in a subject, using, inter alia, an effective amount of a nanoparticle comprising an inner core comprising a non-cellular material, and an outer surface comprising a cellular membrane derived from a source cell. Exemplary toxins include acetylcholinesterase (AChE) inhibitors such as organophosphate poisoning.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: June 14, 2022
    Assignee: The Regents of the University of California
    Inventors: Liangfang Zhang, Zhiqing Pang, Ronnie H. Fang, Che-Ming Jack Hu
  • Delivery of agents using metastable liposomes
    Patent number: 11357725
    Abstract: Metastable liposomal formulations for hydrophobic drug delivery to a tissue or tissue lumen such the bladder have been developed. These are at least one micron in diameter and formed of one or more lipids having entrapped in the lipid a hydrophobic therapeutic, prophylactic or diagnostic agent. The greater stability of these liposomes, as well as the enhanced transfer of entrapped agent into the adjacent tissue, provides for better delivery, especially of hydrophobic agents such as tacrolimus which does not penetrate tissue well. The metastable liposomal formulations can be administered locally, preferably by instillation, or topically, for example, by spraying or painting, to a tissue or tissue lumen such as the bladder in need of treatment.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: June 14, 2022
    Assignee: LIPELLA PHARMACEUTICALS INC.
    Inventors: Jonathan H. Kaufman, Michael B. Chancellor
  • Pharmaceutical composition, preparation and uses thereof
    Patent number: 11357724
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) a biocompatible nanoparticle and of (ii) a pharmaceutical compound of interest, to be administered to a subject in need of such a compound of interest, wherein the nanoparticle potentiates the compound of interest efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm, and its absolute surface charge value is of at least 10 mV (|10 mV|). The invention also relates to such a composition for use for administering the compound of interest to a subject in need thereof, wherein the nanoparticle and the compound of interest are to be administered to said subject between more than 5 minutes and about 72 hours from each other.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: June 14, 2022
    Assignee: CURADIGM SAS
    Inventors: Agnès Pottier, Laurent Levy, Marie-Edith Meyre, Audrey Darmon, Matthieu Germain
  • Nanoparticles as delivery vehicles of active ingredients and methods for the production thereof
    Patent number: 11344499
    Abstract: A nanoparticle comprising a keratin polypeptide and at least one lipophilic active ingredient, wherein the at least one lipophilic active ingredient is non-covalently bound to the keratin polypeptide and can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical, the keratin polypeptide being water-soluble; optionally, the nanoparticle further comprises at least one hydrophilic active ingredient non-covalently bound to the keratin polypeptide, which can be e.g. a therapeutic or diagnostic agent, a nutraceutical, a cosmetic ingredients, a dye or a cosmeceutical.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: May 31, 2022
    Assignee: CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Annalisa Aluigi, Greta Varchi, Giovanna Sotgiu, Andrea Guerrini, Marco Ballestri
  • Nanoliposome-microbubble conjugate including drug for hair loss treatment encapsulated in nanoliposome and composition for alleviating or treating hair loss containing same
    Patent number: 11337923
    Abstract: Provided are a nanoliposome-microbubble conjugate in which a drug for hair loss treatment such as finasteride, minoxidil, dutasteride, etc. is encapsulated in a nanoliposome and a composition for alleviating or treating hair loss containing the same. Since an orally administered agent such as finasteride, currently useful as a drug for hair loss treatment, causes side effects, drug delivery through scalp application is most desirable, but the drug is not delivered to hair follicle cells through scalp application alone. Since a drug for hair loss treatment useful as an external preparation for skin causes various side effects, the concentration thereof that is used needs to be further lowered. The above nanoliposome-microbubble conjugate is capable of increasing the delivery efficiency of a drug for hair loss treatment at a low concentration, and is thus very effective at treating androgenic alopecia.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: May 24, 2022
    Assignee: MOOGENE MEDI CO., LTD.
    Inventor: Kyeong Nam Yu
  • Targeted polymerized nanoparticles for cancer treatment
    Patent number: 11337924
    Abstract: The invention relates to a novel drug delivery vehicle. Various embodiments of the invention provide a hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and non-polymerizable lipids. Therapeutic agents can be loaded into the polymerized liposomal nanoparticle and targeting agents can be conjugated to the surface of the polymerized liposomal nanoparticle. Also described in the invention are methods, compositions and kits that utilize the hybrid polymerized liposomal nanoparticle to treat disease conditions such as various cancers.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: May 24, 2022
    Assignees: Children's Hospital Los Angeles, Nanovalent Pharmaceuticals, Inc.
    Inventors: Jon O. Nagy, Tim Triche, Hyung-Gyoo Kang
  • Core shell silica particles and uses thereof as an anti-bacterial agent
    Patent number: 11324678
    Abstract: This invention provides core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core etched with group I metal silicate. These core shell silica particles have high surface charge density and anti-bacterial activity. Also provided are compositions comprising core shell silica particles, process of making the core shell silica particles and methods of reducing or inhibiting bacterial activity by administering the core shell silica particles or compositions thereof.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: May 10, 2022
    Assignee: Colgate-Palmolive Company
    Inventors: Guisheng Pan, Suman Chopra
  • Hydrogel polymeric compositions and methods
    Patent number: 11324828
    Abstract: Some aspects of this disclosure relate to a method of treating an ophthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel for controlled release of a therapeutic agent.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: May 10, 2022
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, William H. Ransone, II