Patents Examined by Iven Yucel
  • Interaction of BCL-2 and R-RAS
    Patent number: 5705342
    Abstract: The invention provides compositions and methods for screening for agents which are modulators of bcl-2 function and can modulate bcl-2-mediated apoptosis and/or modulate neoplastic and immune conditions dependent upon bcl-2 function. The invention also provides a composition comprising a substantially pure protein complex comprising a R-ras polypeptide and a bcl-2 polypeptide.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 6, 1998
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: James R. Bischoff, Maria Jose Fernandez-Sarabia