Abstract: Pharmaceutical compositions for oromucosal; contact to stimulate host defense mechanisms in a mammal, having an effective amount of Th1 or Th2 stimulating cytokine, and methods of treatment with such compositions are provided.

Abstract: The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch cleavage products that are indicative of Notch activation. The present invention is also directed to methods for detecting a molecule that modulates Notch activation by observing or measuring a change in the amount of Notch expressed on the cell surface or a change in the amount or pattern of Notch cleavage products. The present invention is also directed to a substantially purified activated heterodimeric form of Notch and components thereof and pharmaceutical compositions and kits thereof. The present invention is based, at least in part, on the discovery that Notch in its active form, i.e.

Abstract: Cancer associated with overexpression of class I family of receptor tyrosine kinases, e.g., with overexpresssion of HER-2/neu or overexpression of epidermal growth factor receptor, are treated with strongly binding PPAR&ggr; ligands.

Abstract: The filtration of molten ferrous metal is accomplished by providing a porous ceramic filter preferably comprising particles of alumina and partially stabilized zirconia that are spaced by interconnected cells to form circuitous and tortuous pathways throughout the ceramic body. The filter is a disc-like structure that can have different surface configuration such as corrugations or a waffle design. The filter can be flat-surfaced with an array of cylindrical openings or counterbored openings extending completely through the filter, or with openings extending partially into the filter from the upper and lower sides of the filter. Several relatively thin filters can be arranged in tandem, if desired.