Patents Examined by J. Christopher Ball
  • Patent number: 11662330
    Abstract: The present disclosure relates to biosensors (10) having a receptor layer (5) and a mediator layer (6), the receptor layer including ethylene receptor molecules. The present disclosure also relates to sensor units (20) comprising one or more biosensors (10) and a controller (11). In some embodiments, one or more sensor units (20) may be in wireless communication with a receiver module or a network gateway.
    Type: Grant
    Filed: February 23, 2020
    Date of Patent: May 30, 2023
    Assignee: Strella Biotechnology, Inc.
    Inventor: Katherine Konstantin Sizov
  • Patent number: 11650161
    Abstract: A CMOS-based chip having multiple sensing modalities that are able independently to detect multiple metabolites present in a sample. In particular, the chip provides multiple sensing modalities capable of performing detection within the same physical test volume, i.e. the chip can simultaneously detect a plurality of chemical reactions occurring in the test volume, where each chemical reaction yields a result that is independently detectable. The chip may comprise an optical sensor (e.g. photodiode) and a chemical sensor (e.g. pH sensor, embodied as an ISFET). With this technique, multiple metabolites may be measured in real time using a small scale point-of-care device.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: May 16, 2023
    Assignee: The University Court of the University of Glasgow
    Inventors: David Robert Sime Cumming, Chunxiao Hu, Mohammed Al-Rawhani, Boon Chong Cheah
  • Patent number: 11639912
    Abstract: A reagent layer of a sensor contains as a mediator a quinone compound having a hydrophilic functional group, phenanthrenequinone, and/or a phenanthrenequinone derivative. The quinone compound has a lower redox potential than a conventional mediator, so interfering substances have less effect on detection results with this sensor.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: May 2, 2023
    Inventors: Yoshifumi Takahara, Takahiro Nakaminami, Shin Ikeda
  • Patent number: 11635424
    Abstract: We disclose an in-toilet urinalysis system which includes a system for collection urine and for analysis of urine components using aptamer technology. Urine collection system may dispense urine into cuvettes, channels, or other containers that include aptamers. The aptamers may detect target molecules in urine. The aptamers may measure urine analytes, detect excreted drugs or drug metabolites, or disease markers. Upon binding to the target molecule, the aptamers may produce a signal which a sensor in the toilet may detect. In some embodiments, the signal may be electrochemical, fluorescent, or colorimetric. The measurements obtained from analysis of the urine may be used to assess a user's health or diagnose disease. In some embodiments, the measurements are stored in a controller which may transmit the measurements to a healthcare provider for assessment.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: April 25, 2023
    Assignee: Medic, Inc.
    Inventors: David R. Hall, Dan Allen, Conrad Rosenbrock, Daniel Hendricks, Andrew Nguyen, Steven J. M. Butala, Travis Niederhauser, Terrece Pearman, Joe Fox
  • Patent number: 11630077
    Abstract: The object of the invention is to increase the detection specificity of biosensors. The present invention provides a biosensor characterized in that it comprises an identifier substance that can bind to a detection target substance and an electrode that takes the charge of said identifier substance, wherein the biosensor detects the change in the charge density of said electrode generated by the binding of said detection target substance with said identifier substance, the surface of said electrode is coated with polycatecholamine, all or a part of said electrode surface coated with polycatecholamine further has a polymer layer formed thereon which has a molecular imprint having a structure complementary to the molecular structure of the detection target substance formed therein, said polymer layer comprises said identifier substance, and said polymer layer is an ultrathin film layer.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: April 18, 2023
    Assignee: Provigate Inc.
    Inventors: Taira Kajisa, Yoshiyuki Yanagimoto
  • Patent number: 11629369
    Abstract: Devices, systems, and methods are used for personalized monitoring of changes in metabolism as a function of external parameters such as food or physical exercise. More particularly, the present disclosure relates to electrochemical strips for detecting the amount of biomarker for fat metabolism, in particular, glycerol.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: April 18, 2023
    Assignee: LSEE
    Inventors: S├ębastien Delile, Cyril Torre
  • Patent number: 11624723
    Abstract: A biosensor component is provided that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate, a conductive layer deposited on the substrate, and a resistive material layer deposited on the conductive layer. The conductive layer includes nickel, chromium, and iron, such that a combined weight percent of the nickel and chromium in the conductive layer is in the range of 25 to less than 95 weight percent, the weight percent of nickel in the conductive layer is at least 8 weight percent, the weight percent of chromium in the conductive layer is at least 10 weight percent, the weight percent of iron in the conductive layer at least 2 weight percent, and such that the conductive layer comprises 0 to 20 weight percent molybdenum.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: April 11, 2023
    Assignee: Eastman Chemical Company
    Inventors: Spencer Erich Hochstetler, Dennis Lee Ashford, II, Senthil Sambandam
  • Patent number: 11624091
    Abstract: Nucleic acid molecule analysis systems are described. The system may include a nucleic acid molecule attached to a particle with a characteristic dimension. The system may also include an aperture defined by a first electrode, a first insulator, and a second electrode. The aperture may have a characteristic dimension less than the characteristic dimension of the particle. The system may further include a first power supply in electrical communication with the first electrode and the second electrode. In addition, the system may include a second power supply configured to apply an electric field through the aperture. In some embodiments, the aperture may be defined by a first insulator. A portion of the first electrode may extend into the aperture. A portion of the second electrode may extend into the aperture.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: April 11, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventor: Yann Astier
  • Patent number: 11618025
    Abstract: Provided is an apparatus, system and method for on-chip microfluids dispensing. The apparatus comprising a substrate; a plurality of first electrodes arranged one next to another on the substrate; a dielectric layer above and enclosing the plurality of first electrodes; and a second electrode on the substrate, wherein each of the plurality of first electrodes is in electric communication with a respective first driving signal input; wherein the second electrode is in electric communication with a second driving signal input; wherein the plurality of first electrodes define a continuous fluid path along a longitudinal direction for retaining microfluids, and wherein the second electrode is arranged within the continuous fluid path and defines a jetting position and an adjacent mixing position within the continuous fluid path.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: April 4, 2023
    Assignee: University of Macau
    Inventors: Yanwei Jia, Haoran Li, Ren Shen, Cheng Dong, Tianlan Chen, Jie Gao, Pui-ln Mak, Rui Paulo da Silva Martins
  • Patent number: 11618042
    Abstract: The disclosure relates to a dielectrophoretic tweezer, and associated methods of fabrication and use. The tweezer comprises a first end and a second end, in which the first end has a lateral dimension of less than 10 microns; a structure, extending in a longitudinal direction between the first and second ends, comprising an electrically insulating barrier defining a first chamber and a second chamber within the structure, in which the first and second chambers are insulated from each other by the electrically insulating barrier; a first electrode in the first chamber at the first end; and a second electrode in the second chamber at the first end, in which a width of the electrically insulating barrier separating the first electrode from the second electrode is 50 nm or less.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: April 4, 2023
    Assignee: Imperial College Innovations Limited
    Inventors: Joshua Edel, Aleksandar Ivanov, Binoy Paulose Nadappuram, Paolo Cadinu
  • Patent number: 11612655
    Abstract: Some embodiments provide a system for external manipulation of magnetic nanoparticles in vasculature using a remotely placed magnetic field-generating stator. In one aspect, the systems and methods relate to the control of magnetic nanoparticles in a fluid medium using permanent magnet-based or electromagnetic field-generating stator sources. Such a system can be useful for increasing the diffusion of therapeutic agents in a fluid medium, such as a human circulatory system, which can result in substantial clearance of fluid obstructions, such as vascular occlusions, in a circulatory system resulting in increased blood flow.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: March 28, 2023
    Assignee: Pulse Therapeutics, Inc.
    Inventor: Francis M. Creighton
  • Patent number: 11607658
    Abstract: The present invention generally relates to microfluidic droplets and, including forming gels within microfluidic droplets. In some aspects, a fluid containing agarose or other gel precursors is transported into a microfluidic droplet, and caused to harden within the droplet, e.g., to form a gel particle contained within the microfluidic droplet. Surprisingly, a discrete gel particle may be formed even if the fluid containing the agarose or other gel precursor, and the fluid contained within the microfluidic droplet, are substantially immiscible. Other aspects of the present invention are generally directed to techniques for making or using such gels within microfluidic droplets, kits containing such gels within microfluidic droplets, or the like.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: March 21, 2023
    Assignees: President and Fellows of Harvard College, Massachusetts Eye and Ear Infirmary
    Inventors: David A. Weitz, Huidan Zhang, Nai Wen Cui, Fengyang Lei, Eleftherios Paschalis Ilios
  • Patent number: 11604158
    Abstract: A method for determining contamination of a biosensor in which the biosensor is loaded into a test meter and a sample is then applied. First and second predetermined test voltages are applied between spaced electrodes of the biosensor for respective first and second predetermined time intervals. First and second current values are measured during the respective first and second predetermined time intervals. Reference values are determined based on the measured first and second current values. Based on one or more of the reference values, a determination of contamination is made. Reporting of the analyte concentration of the sample can be suppressed based on the determination.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: March 14, 2023
    Assignee: LifeScan IP Holdings, LLC
    Inventors: David McColl, Allan MacRae, Gavin MacFie, Stephen Mackintosh, David Morris, Joanne Watt, Antony Smith
  • Patent number: 11592437
    Abstract: Methods and devices for quantifying creatinine in a test sample are provided. The test sample is contacted with a sensing composition to obtain a product comprising a hydantoin-transition metal complex and ammonia. The sensing composition comprises creatinine deaminase and a transition metal salt. The creatinine deaminase enzymatically reacts with creatinine to provide the N-methyl hydantoin and ammonia. The N-methyl hydantoin forms the hydantoin-transition metal complex with the transition salt. A potential difference is applied to the product to measure a current signal provided by the hydantoin-transition metal complex. Concentration of N-methyl hydantoin is obtained based on the measured current signal using a calibration equation. The concentration of N-methyl hydantoin is correlated with concentration of creatinine to quantify the creatinine in the test sample.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: February 28, 2023
    Assignee: Indian Institute of Science
    Inventors: Pallavi Dasgupta, Patnam Krishnaswamy, Vinay Kumar, Navakanta Bhat
  • Patent number: 11592443
    Abstract: The present disclosure provides new approaches in developing templated polymer-based chemical receptors. At least some embodiments of the invention use a stimuli-responsive polymer [e.g., poly-Nisopropylacrylamide (pNIPAM)] as a polymer backbone with the incorporation of functional monomers (for analyte recognition). In at least some embodiments of the invention, vinylferrocene may be used as a redox-active label for electrochemical transduction.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: February 28, 2023
    Assignee: University of New Hampshire
    Inventors: Edward Song, William Rudolf Seitz, Jeffrey M. Halpern
  • Patent number: 11583848
    Abstract: The present invention discloses a nanoparticle control and detection system and operating method thereof. The present invention controls and detects the nanoparticles in the same device. The device comprises a first transparent electrode, a photoconductive layer, a spacer which is deposed on the edge of the photoconductive layer and a second transparent electrode. The aforementioned device controls and detects the nanoparticles by applying AC/DC bias and AC/DC light source to the transparent electrode.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: February 21, 2023
    Inventors: Chia-Ming Yang, Chao-Sung Lai, Yu-Ping Chen, Min-Hsien Wu
  • Patent number: 11573198
    Abstract: A fluidic apparatus for detection of a chemical substance, a biosensor, and a method of fabricating the fluidic apparatus. The fluidic apparatus includes a fluidic structure arranged to receive a sample containing a target substance, and a trapping structure, in fluid communication with the fluidic structure and arranged to immobilize the target substance in a detection region, wherein the detection region of the trapping structure is arranged to alter a physical characteristic of an incident light signal which represents a concentration of the target substance contained in the sample.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: February 7, 2023
    Assignee: City University of Hong Kong
    Inventors: Stella W. Pang, Shuyan Zhu
  • Patent number: 11567060
    Abstract: Example nanopore sequencers include a cis well, a trans well, and a nanopore fluidically connecting the cis and trans wells. In one example sequencer, a modified electrolyte (including an electrolyte and a cation complexing agent) is present in the cis well, or the trans well, or in the cis and the trans wells. In another example sequencer, a gel state polyelectrolyte is present in the cis well, or the trans well, or in the cis and the trans wells.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: January 31, 2023
    Assignee: Illumina, Inc.
    Inventors: Boyan Boyanov, Rohan N. Akolkar, Jeffrey S. Fisher, Jeffrey G. Mandell, Liangliang Qiang, Steven M. Barnard
  • Patent number: 11567061
    Abstract: Systems and methods are provided for trapping and electrically monitoring molecules in a nanopore sensor. The nanopore sensor comprises a support structure with a first and a second fluidic chamber, at least one nanopore fluidically connected to the two chambers, and a protein shuttle. The protein shuttle comprises an electrically charged protein molecule, such as Avidin. The nanopore can be a Clytosolin A. A method can comprise applying a voltage across the nanopores to draw protein shuttles towards the nanopores. The ionic current through each or all of the nanopores can be concurrently measured. Based on the measured ionic current, blockage events can be detected. Each blockage event indicates a capture of a protein shuttle by at least one nanopore. Each blockage event can be detected through a change of the total ionic current flow or a change in the ionic current flow for a particular nanopore.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: January 31, 2023
    Inventors: Lene V. Hau, Jene A. Golovchenko, Min Chen
  • Patent number: 11559817
    Abstract: Devices and methods for capturing biological materials using a potential well. An electrical signal is applied across a nanopipette having one end in a back-fill chamber and another end in a collection chamber containing a suspending medium including one or more types of particles. The collection end of the nanopipette includes a tip having an opening. The electrical signal applied across the nanopipette is configured to generate the potential well proximate to the tip in which the electrokinetic forces acting on the particles are balanced. The potential well may be configured to selectively trap one or the other types of particles suspended in the suspending medium. The particles may be transferred to a sample collection medium by immersing the tip in the sample collection medium and reversing the polarity of the electrical signal.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: January 24, 2023
    Assignee: University of Cincinnati
    Inventor: Leyla Esfandiari