Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Abstract: Devices, methods for fabricating said devices, and methods for detecting an analyte within a bio-target are described herein. The device includes a top assembly and a bottom assembly. The Top assembly includes an electrode disposed on a top layer. The bottom assembly includes a bio-chip disposed on a bottom layer and a polymer body disposed between the bio-chip and the top assembly. The polymer body includes a channel. The electrode of the top assembly is positioned within the channel. The channel is configured to accommodate the bio-target containing the analyte.

Abstract: A cell to process a substrate includes at least one chamber wall, a membrane frame, and a membrane. The at least one chamber wall is arranged to form a cavity below a holder of the substrate. The membrane frame is disposed on the at least one chamber wall and across the cavity. The membrane is supported by the membrane frame and separating a first electrolyte from a second electrolyte. The membrane includes a surface extending from a center of the cavity radially outward at an angle relative to a reference plane, and wherein the angle is greater than or equal to 0° and less than or equal to 3°.

Abstract: A test cell for operando testing comprises: a housing assembly defining at least a portion of an inner chamber; a window coupled to said housing assembly and defining another portion of the inner chamber; and at least one port for accommodating an electrode and/or conductive wire in communication with the inner chamber. The inner chamber is configured for receiving one or more samples undergoing a chemical and/or electrochemical reaction therein. The port is sealable to hermetically seal the inner chamber.

Abstract: The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides bioelectronic devices, and methods of making bioelectronic devices, comprising adjustable adaptor polypeptides with repeatable motifs and enhanced conductive properties. The bioelectronic devices and methods of the present disclosure are useful for a variety of applications, including the direct measurement of protein activity (e.g., when sequencing a biopolymer).

Abstract: An integrated semiconductor device for manipulating and processing bio-entity samples and methods are described. The device includes a lower substrate, at least one optical signal conduit disposed on the lower substrate, at least one cap bonding pad disposed on the lower substrate, a cap configured to form a capped area, and disposed on the at least one cap bonding pad, a fluidic channel, wherein a first side of the fluidic channel is formed on the lower substrate and a second side of the fluidic channel is formed on the cap, a photosensor array coupled to sensor control circuitry, and logic circuitry coupled to the fluidic control circuitry, and the sensor control circuitry.

Abstract: The disclosure relates to a rapid and comprehensive method for evaluating pitting resistance of stainless steel pipe welds. Weld samples are collected from different positions of one or more welds on the stainless steel pipe to obtain the surface oxide inclusion density and critical pitting temperature of each weld sample, the surface oxidation inclusion density is taken as an independent variable and the critical pitting temperature is taken as a dependent variable to obtain a fitting function formula between the surface oxidation inclusion density and the critical pitting temperature. The surface oxide inclusion density obtained by adopting the same welding process on the stainless steel pipe to be tested is substituted into the fitting function formula to obtain a standard critical pitting temperature of the weld to be tested. The pitting resistance of the weld of the stainless steel pipe to be tested can be evaluated rapidly, accurately, and comprehensively.

Abstract: Microchip Capillary Electrophoresis (MCE) assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.

Abstract: The present application discloses an enzymatic electrode system and its applications. The enzymatic electrode system comprises a working electrode, a counter electrode, and an optional reference electrode. The working electrode includes an electrode support substrate and a conductive substrate located at the top of the electrode support substrate. The surface or interior of the conductive substrate contains oxidoreductases, coenzyme reductases, and optional coenzymes. This application utilizes a comprehensive enzymatic electrode system incorporating oxidoreductases, coenzyme reductases, and coenzymes for the detection of specific substances in samples, such as glucose, lactate, ketones, and the like.

Abstract: MCE assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.

Abstract: Circuitry for and methods of analyte measurement Circuitry for measuring a characteristic of an electrochemical cell, the circuitry comprising: a hysteretic comparator having a first comparator input, a second comparator input and a comparator output; a feedback path between the comparator output and the second comparator input configured to provide a feedback signal to the second comparator input; and a loop filter configured to apply filtering to the feedback path to generate the feedback signal, wherein the loop filter comprises the electrochemical cell.

Abstract: A fluid property sensing array includes a first sensor including a first electrode assembly and a first sensing layer at least partially coating the first electrode assembly, the first sensor having a first response to a property of the fluid; and a second sensor including a second electrode assembly and a second sensing layer at least partially coating the second electrode assembly, the second sensor having a second response to the property of the fluid. The array can include a third sensor including a third electrode assembly and a third sensing layer at least partially coating the third electrode assembly, the third sensor having a third response to the property of the fluid. The first sensing layer, the second sensing layer, and the third sensing layer can be compositionally different, such that the first response, the second response, and the third response to the property of the fluid are different.

Abstract: A gas sensor (1) including a sensor element (10); a metallic shell (138); a tubular outer surface member (190) attached directly or indirectly to the metallic shell, constitutes an outer surface of the gas sensor, and extends toward a rear end side in relation to the metallic shell; and a tubular protection member (210, 220) which is detachably fixed to a fixation region C1, C2 of an outer circumference of the outer surface member. The protection member includes a first arc portion (212), a second arc portion (222), and a fixation portion (214,224) brought into contact with and is fixed to the fixation region. When the protection member fixed to the outer circumference of the outer surface member by fixing the fixation portion to the fixation region is viewed in the axial O direction, the first arc portion and the second arc portion cover in total at least 90% of the entire circumference of the outer surface of the outer surface member.

Abstract: Provided herein are methods for moving molecular hoppers along tracks; methods of characterising an analyte using molecular hoppers; kits for characterising an analyte; and molecule hoppers per se and systems comprising such hoppers. The invention particularly relates to the use of such methods and kits in the characterisation of analytes.

Abstract: A sensor can include a redox-active complex. The sensor can be voltage sensitive.

Abstract: The present application relates to an electrode catalyst for water electrolysis including a first transition metal foam, a metal layered double hydroxide (LDH)/metal oxide mixed layer which contains a second transition metal and a third transition metal that are formed on the surface of the first transition metal foam, and fourth transition metal oxyhydroxide nanoparticles formed on the surface of the mixed layer, in which the mixed layer surface contains the metal layered double hydroxide.

Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.

Abstract: An electrode for enzymatic biosensor being in the form of a fibrous material and comprising electrically conductive fibres and electrically non-conductive fibres, all or part of which are functionalised by enzymes, identical or different. A method for preparing such an electrode and an electrochemical detection enzymatic biosensor comprising same.

Abstract: A sensor for detecting lead in an aqueous solution includes a copper working electrode, a counter electrode, a power supply for applying underpotential deposition of lead onto the copper electrode, a measuring device for providing measurement of a hydrogen evolution reaction (HER) current on the Pbupd-modified electrode, and a controller configured to correlate the degree of suppression of the HER current to Pbupd coverage to determine the lead coverage and lead concentration of the solution.

Abstract: An embodiment provides a method for measuring a component of an aqueous sample using square wave modulation, including: introducing the aqueous sample to a chamber of a square wave modulation apparatus; applying a stimulus voltage step to the aqueous sample, wherein the stimulus voltage comprises a staircase voltage, wherein each step of the staircase voltage defines a group, wherein the group comprises one or more square wave modulation cycles; adjusting a time acquisition window, wherein the time acquisition window is a portion of each of the half cycle of the stimulus voltage; measuring a resultant current output resulting from the stimulus voltage within the time acquisition windows; and averaging the resultant current output across at least one or more cycles of each group. Other aspects are described and claimed.