Patents Examined by J. Christopher Ball
  • Patent number: 12285271
    Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.
    Type: Grant
    Filed: October 24, 2024
    Date of Patent: April 29, 2025
    Assignee: Biolinq Incorporated
    Inventors: Alan Campbell, Sirilak Sattayasamitsathit, Jared Rylan Tangney, Joshua Ray Windmiller, James Patrick McCanna
  • Patent number: 12281998
    Abstract: Devices, methods for fabricating said devices, and methods for detecting an analyte within a bio-target are described herein. The device includes a top assembly and a bottom assembly. The Top assembly includes an electrode disposed on a top layer. The bottom assembly includes a bio-chip disposed on a bottom layer and a polymer body disposed between the bio-chip and the top assembly. The polymer body includes a channel. The electrode of the top assembly is positioned within the channel. The channel is configured to accommodate the bio-target containing the analyte.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: April 22, 2025
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yi-Hsing Hsiao, Jui-Cheng Huang
  • Patent number: 12281402
    Abstract: A cell to process a substrate includes at least one chamber wall, a membrane frame, and a membrane. The at least one chamber wall is arranged to form a cavity below a holder of the substrate. The membrane frame is disposed on the at least one chamber wall and across the cavity. The membrane is supported by the membrane frame and separating a first electrolyte from a second electrolyte. The membrane includes a surface extending from a center of the cavity radially outward at an angle relative to a reference plane, and wherein the angle is greater than or equal to 0° and less than or equal to 3°.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: April 22, 2025
    Assignee: Lam Research Corporation
    Inventors: Frederick Dean Wilmot, Robert Rash, Nirmal Shankar Sigamani, Gabriel Graham
  • Patent number: 12276632
    Abstract: A test cell for operando testing comprises: a housing assembly defining at least a portion of an inner chamber; a window coupled to said housing assembly and defining another portion of the inner chamber; and at least one port for accommodating an electrode and/or conductive wire in communication with the inner chamber. The inner chamber is configured for receiving one or more samples undergoing a chemical and/or electrochemical reaction therein. The port is sealable to hermetically seal the inner chamber.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: April 15, 2025
    Assignee: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION
    Inventors: Kevin Wood, Aleksandr Aleshin
  • Patent number: 12276653
    Abstract: The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides bioelectronic devices, and methods of making bioelectronic devices, comprising adjustable adaptor polypeptides with repeatable motifs and enhanced conductive properties. The bioelectronic devices and methods of the present disclosure are useful for a variety of applications, including the direct measurement of protein activity (e.g., when sequencing a biopolymer).
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: April 15, 2025
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventor: Stuart Lindsay
  • Patent number: 12264362
    Abstract: An integrated semiconductor device for manipulating and processing bio-entity samples and methods are described. The device includes a lower substrate, at least one optical signal conduit disposed on the lower substrate, at least one cap bonding pad disposed on the lower substrate, a cap configured to form a capped area, and disposed on the at least one cap bonding pad, a fluidic channel, wherein a first side of the fluidic channel is formed on the lower substrate and a second side of the fluidic channel is formed on the cap, a photosensor array coupled to sensor control circuitry, and logic circuitry coupled to the fluidic control circuitry, and the sensor control circuitry.
    Type: Grant
    Filed: July 17, 2023
    Date of Patent: April 1, 2025
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Allen Timothy Chang, Yi-Hsien Chang, Chun-Ren Cheng
  • Patent number: 12259313
    Abstract: The disclosure relates to a rapid and comprehensive method for evaluating pitting resistance of stainless steel pipe welds. Weld samples are collected from different positions of one or more welds on the stainless steel pipe to obtain the surface oxide inclusion density and critical pitting temperature of each weld sample, the surface oxidation inclusion density is taken as an independent variable and the critical pitting temperature is taken as a dependent variable to obtain a fitting function formula between the surface oxidation inclusion density and the critical pitting temperature. The surface oxide inclusion density obtained by adopting the same welding process on the stainless steel pipe to be tested is substituted into the fitting function formula to obtain a standard critical pitting temperature of the weld to be tested. The pitting resistance of the weld of the stainless steel pipe to be tested can be evaluated rapidly, accurately, and comprehensively.
    Type: Grant
    Filed: September 4, 2024
    Date of Patent: March 25, 2025
    Assignee: Tianjin University
    Inventors: Lianyong Xu, Yongdian Han, Yongle Shi, Lei Zhao, Kangda Hao
  • Patent number: 12259355
    Abstract: Microchip Capillary Electrophoresis (MCE) assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: March 25, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Timothy Riehlman, Gabriel Carreau, Jeffrey Schneiderheinze, Nicole M. Nall
  • Patent number: 12252729
    Abstract: The present application discloses an enzymatic electrode system and its applications. The enzymatic electrode system comprises a working electrode, a counter electrode, and an optional reference electrode. The working electrode includes an electrode support substrate and a conductive substrate located at the top of the electrode support substrate. The surface or interior of the conductive substrate contains oxidoreductases, coenzyme reductases, and optional coenzymes. This application utilizes a comprehensive enzymatic electrode system incorporating oxidoreductases, coenzyme reductases, and coenzymes for the detection of specific substances in samples, such as glucose, lactate, ketones, and the like.
    Type: Grant
    Filed: January 23, 2024
    Date of Patent: March 18, 2025
    Assignee: Oxsyns.co
    Inventors: Yilin Fan, Beichen Cheng, Yu Sun
  • Patent number: 12253490
    Abstract: MCE assays and reagents to assess purity and to identify impurities in protein drug product samples are provided. Methods for analyzing analytes in a protein drug sample are provided.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: March 18, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Timothy Riehlman, Gabriel Carreau, Jeffrey Schneiderheinze, Nicole M. Nall
  • Patent number: 12253487
    Abstract: Circuitry for and methods of analyte measurement Circuitry for measuring a characteristic of an electrochemical cell, the circuitry comprising: a hysteretic comparator having a first comparator input, a second comparator input and a comparator output; a feedback path between the comparator output and the second comparator input configured to provide a feedback signal to the second comparator input; and a loop filter configured to apply filtering to the feedback path to generate the feedback signal, wherein the loop filter comprises the electrochemical cell.
    Type: Grant
    Filed: August 25, 2022
    Date of Patent: March 18, 2025
    Assignee: Cirrus Logic Inc.
    Inventors: John Paul Lesso, Toru Ido
  • Patent number: 12247940
    Abstract: A fluid property sensing array includes a first sensor including a first electrode assembly and a first sensing layer at least partially coating the first electrode assembly, the first sensor having a first response to a property of the fluid; and a second sensor including a second electrode assembly and a second sensing layer at least partially coating the second electrode assembly, the second sensor having a second response to the property of the fluid. The array can include a third sensor including a third electrode assembly and a third sensing layer at least partially coating the third electrode assembly, the third sensor having a third response to the property of the fluid. The first sensing layer, the second sensing layer, and the third sensing layer can be compositionally different, such that the first response, the second response, and the third response to the property of the fluid are different.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: March 11, 2025
    Assignee: THE UNIVERSITY OF AKRON
    Inventors: Jiang Zhe, Dian Jiao, Aaron Urban
  • Patent number: 12247944
    Abstract: A gas sensor (1) including a sensor element (10); a metallic shell (138); a tubular outer surface member (190) attached directly or indirectly to the metallic shell, constitutes an outer surface of the gas sensor, and extends toward a rear end side in relation to the metallic shell; and a tubular protection member (210, 220) which is detachably fixed to a fixation region C1, C2 of an outer circumference of the outer surface member. The protection member includes a first arc portion (212), a second arc portion (222), and a fixation portion (214,224) brought into contact with and is fixed to the fixation region. When the protection member fixed to the outer circumference of the outer surface member by fixing the fixation portion to the fixation region is viewed in the axial O direction, the first arc portion and the second arc portion cover in total at least 90% of the entire circumference of the outer surface of the outer surface member.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 11, 2025
    Assignee: NITERRA CO., LTD.
    Inventors: Sunchao Liu, Kazuhiro Kouzaki, Takehiro Oba, Motohiko Nakamura, Kenji Masuda
  • Patent number: 12247990
    Abstract: Provided herein are methods for moving molecular hoppers along tracks; methods of characterising an analyte using molecular hoppers; kits for characterising an analyte; and molecule hoppers per se and systems comprising such hoppers. The invention particularly relates to the use of such methods and kits in the characterisation of analytes.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: March 11, 2025
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Yujia Qing, John Hagan Pryce Bayley
  • Patent number: 12247945
    Abstract: A sensor can include a redox-active complex. The sensor can be voltage sensitive.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: March 11, 2025
    Assignees: Massachusetts Institute of Technology, King Abdullah University of Science and Technology
    Inventors: Timothy M. Swager, Suchol Savagatrup, Vera Schroder, Maggie He, Sibo Lin, Xi-Xiang Zhang, Khaled N. Salama
  • Patent number: 12241166
    Abstract: The present application relates to an electrode catalyst for water electrolysis including a first transition metal foam, a metal layered double hydroxide (LDH)/metal oxide mixed layer which contains a second transition metal and a third transition metal that are formed on the surface of the first transition metal foam, and fourth transition metal oxyhydroxide nanoparticles formed on the surface of the mixed layer, in which the mixed layer surface contains the metal layered double hydroxide.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: March 4, 2025
    Assignees: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, INSTITUTE FOR BASIC SCIENCE
    Inventors: Hyoyoung Lee, Jadhav Amol
  • Patent number: 12241857
    Abstract: Disclosed are systems and methods for delivering and/or linking molecules, such as DNA, between tunable metal nanogaps and measuring electrical and/or optical properties. In one example, disclosed are high density multiplexed chips with a plurality of groups, each group including a plurality of nanodevices, the chips capable of coupling to one or more multiwell structures for providing samples to each individual group. In this way, the chips can be used for high-throughput analysis of molecules such as DNA.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: March 4, 2025
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventor: Quan Qing
  • Patent number: 12241856
    Abstract: An electrode for enzymatic biosensor being in the form of a fibrous material and comprising electrically conductive fibres and electrically non-conductive fibres, all or part of which are functionalised by enzymes, identical or different. A method for preparing such an electrode and an electrochemical detection enzymatic biosensor comprising same.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: March 4, 2025
    Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
    Inventors: Frédéric Revol-Cavalier, Pascal Mailley, Natalie Perrault, Anne Perwuelz, Philippe Vroman
  • Patent number: 12241862
    Abstract: A sensor for detecting lead in an aqueous solution includes a copper working electrode, a counter electrode, a power supply for applying underpotential deposition of lead onto the copper electrode, a measuring device for providing measurement of a hydrogen evolution reaction (HER) current on the Pbupd-modified electrode, and a controller configured to correlate the degree of suppression of the HER current to Pbupd coverage to determine the lead coverage and lead concentration of the solution.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: March 4, 2025
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Rohan Akolkar, Xinyu Liu, Kailash Venkatraman
  • Patent number: 12235237
    Abstract: An embodiment provides a method for measuring a component of an aqueous sample using square wave modulation, including: introducing the aqueous sample to a chamber of a square wave modulation apparatus; applying a stimulus voltage step to the aqueous sample, wherein the stimulus voltage comprises a staircase voltage, wherein each step of the staircase voltage defines a group, wherein the group comprises one or more square wave modulation cycles; adjusting a time acquisition window, wherein the time acquisition window is a portion of each of the half cycle of the stimulus voltage; measuring a resultant current output resulting from the stimulus voltage within the time acquisition windows; and averaging the resultant current output across at least one or more cycles of each group. Other aspects are described and claimed.
    Type: Grant
    Filed: April 6, 2022
    Date of Patent: February 25, 2025
    Assignee: HACH COMPANY
    Inventor: David Langley Rick