Patents Examined by J. Christopher Ball
  • Patent number: 10895551
    Abstract: A system for “signal-on” electrochemical detection of molecules of interest and to a method implementing said system.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: January 19, 2021
    Assignees: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Hafsa Korri-Youssoufi, Anna Miodek, Nawel Mejri
  • Patent number: 10895549
    Abstract: The present invention relates to an electrochemical sensor for determining the presence or quantity (eg concentration) of an oxidant of interest in an aqueous solution.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: January 19, 2021
    Assignee: Palintest Limited
    Inventors: Simon Johnston, Stephen William Birch
  • Patent number: 10895552
    Abstract: A method for preparing a ratiometric electrochemical aptasensor for vanillin based on an aptamer-gold nanoparticle-ferrocene-Ketjenblack-ZIF-8 nanocomposite modified electrode includes, dripping ZIF-8 nanocomposite doped with ferrocene and Ketjenblack on the surface of the bare glassy carbon electrode, and immersing this modified electrode in the chloroauric acid solution. The cyclic voltammetry is employed to scan and electrodeposit gold nanoparticles to obtain the gold nanoparticle-deposited ZIF-8 nanocomposite. The aptamer of vanillin is attached to gold nanoparticles via Au—S bonds to construct an aptamer-coupled nanocomposite sensing platform. Then, the electrochemical curves in the presence of different vanillin concentrations are measured, the linear relationship between the ratios of the current peak intensities of ferrocene and vanillin and the molar concentrations of vanillin is fitted, and the ratiometric electrochemical aptasensor for vanillin is constructed.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: January 19, 2021
    Assignee: QINGDAO UNIVERSITY
    Inventors: Rijun Gui, Yujiao Sun, Hui Jin, Xiaowen Jiang
  • Patent number: 10890557
    Abstract: The present disclosure relates to an electron transfer mediator comprising the osmium complex or a salt thereof, a reagent composition for an electrochemical biosensor, and an electrochemical biosensor, where the osmium compound or its salt maintains a stable oxidation-reduction form for an extended time period, a capacity to react with oxidoreductase being capable of performing the redox reaction of the target analytes, and no effect of oxygen partial pressure.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: January 12, 2021
    Assignee: I-SENS, INC.
    Inventors: In Jun Yoon, Jae Ho Shin, Yeon Ho Jung, Geun Sig Cha, Hakhyun Nam
  • Patent number: 10890552
    Abstract: A gas sensor includes a pump cell unit that regulates the oxygen concentration of a measured gas using a pump electrode, a monitor cell unit that detects the residual oxygen concentration of the measured gas using a monitor electrode, and a sensor cell unit that detects the concentration of a specific gas component in the measured gas using a sensor electrode. Between a pump electrode lead part and the sensor electrode, there is arranged the monitor electrode. Between an upstream portion of the pump electrode lead part and a monitor electrode lead part, there is provided an interval w1 of 0.5 mm or more.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: January 12, 2021
    Assignee: DENSO CORPORATION
    Inventors: Keigo Mizutani, Keisuke Mizutani, Mitsunobu Nakato, Takashi Araki
  • Patent number: 10883956
    Abstract: A sensor for the detection of an analyte in a biological sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and a receptor functionalized or chemically functionalized to a surface of an exposed portion of the working electrode. The receptor can selectively bind to the analyte of interest and the analyte once bound is detectable by measuring the current flow between the working electrode and counter electrode.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Chung-Chiun Liu
  • Patent number: 10883959
    Abstract: A plate-shaped sensor element (10) including at least a first layer (150), a second layer (130), and a third layer (140) being stacked in a stacking direction. The first layer and the third layer are mainly formed of ceramic. The second layer is disposed between the first layer and the third layer in the stacking direction. The second layer has an air introduction hole (131) opened at an end surface. In a cross-section perpendicular to a direction of an axis O, a length L1 of a shortest line segment P1 connecting an upper end surface (10a, 10b) of the sensor element and the centroid G1 of the sensor element and a length L2 of a shortest line segment P2 connecting the upper end surface of the sensor element and the centroid G2 of the air introduction hole, satisfy a relationship of |L2?L1|/L1?0.05.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: January 5, 2021
    Assignee: NGK SPARK PLUG CO., LTD.
    Inventors: Ai Igarashi, Kouji Toida, Shun Sakuma
  • Patent number: 10876159
    Abstract: The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value. The present invention accordingly enables direct rapid implementation to identify nucleotides and to determine a nucleotide sequence in a polynucleotide without marking.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: December 29, 2020
    Assignee: QUANTUM BIOSYSTEMS INC.
    Inventors: Masateru Taniguchi, Makusu Tsutsui, Kazumichi Yokota, Tomoji Kawai
  • Patent number: 10871463
    Abstract: A preparation method based on simultaneous package of a target substance and synthesis of MOFs with redox activity, wherein methylene blue is selected as an organic target molecule, the methylene blue is packaged in the MOFs when the MOFs are synthesized by using a one-pot method to obtain ZIF-8 modified by the methylene blue. The drawback that above-mentioned MOFs material does not have electrical conductivity is overcome, the method is simple, rapid and low in cost, and the prepared product can accurately, sensitively, simply and quickly detect dopamine, and a new development direction is provided for researches in the fields of biological detection and chemical analysis, etc.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 22, 2020
    Assignee: QINGDAO UNIVERSITY
    Inventors: Zonghua Wang, Gege Yu, Jianfei Xia, Shida Gong
  • Patent number: 10871466
    Abstract: A sensor device including a substrate that is transparent and/or flexible, and a transparent sensor array disposed on the substrate. The transparent sensor array includes transparent sensor circuits and transparent interconnects electrically coupled to the transparent sensor circuits. Each of the transparent sensor circuits includes a transparent transistor. A transparent slide may include a transparent sensor circuit disposed on a transparent substrate. The slide may be prepared for observation of a specimen by placing the specimen in fluidic communication with the transparent sensor circuit. A flexible sensor device may include an array of transparent sensor circuits disposed on a flexible substrate. The flexible sensor device may be placed on the surface of an object to determine parameters at locations adjacent to the surface of the object. A method of fabricating an integrated circuit may include using a multilayer etch mask of electron-beam resist and photoresist.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 22, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Charles E. Mackin, Tomás Apostol Palacios
  • Patent number: 10865443
    Abstract: An integrated semiconductor device for manipulating and processing bio-entity samples and methods are described. The device includes a lower substrate, at least one optical signal conduit disposed on the lower substrate, at least one cap bonding pad disposed on the lower substrate, a cap configured to form a capped area, and disposed on the at least one cap bonding pad, a fluidic channel, wherein a first side of the fluidic channel is formed on the lower substrate and a second side of the fluidic channel is formed on the cap, a photosensor array coupled to sensor control circuitry, and logic circuitry coupled to the fluidic control circuitry, and the sensor control circuitry.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: December 15, 2020
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.
    Inventors: Allen Timothy Chang, Yi-Hsien Chang, Chun-Ren Cheng
  • Patent number: 10866207
    Abstract: An exhaust gas sensor for detecting a measurement gas component, having a ceramic sensor element fixed in a housing, and a double-walled protective pipe having outer and inner protective sleeves, the inner sleeve enclosing a gas chamber into which the sensor element extends with a segment at the measurement gas side, in the direction of a longitudinal axis of the sensor, and an annular chamber being formed between the outer and inner protective sleeves. The outer sleeve has a cladding surface having at least one opening configured as a swirling element, through which measurement gas can move into the annular chamber with rotation about a longitudinal axis of the sensor, and the inner sleeve has at least one opening that is adjusted and/or functionally optimized, as to a sensitive region of the sensor element, through which opening the measurement gas can move from the annular chamber into the gas chamber.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: December 15, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Johannes Weber, Benjamin Sillmann, Christoph Gmelin, Christopher Holzknecht, Karel Vacha, Katerina Lieblova, Milan Kotynek, Rafael Gitzmann, Sebastian Schulte Am Huelse, Simon Rentschler, Stefan Buehler
  • Patent number: 10850272
    Abstract: An electrowetting-on-dielectric actuator may include an array of electrodes and a dielectric layer. The actuator may modulate voltage of the electrodes in such a way that time-varying electric fields created by the electrodes cause droplets of liquid to move relative to the actuator. The electric fields may cause the droplets to press up against a bottom surface of the actuator while the droplets are under and touching the bottom surface. The droplets may then be released from the bottom surface and thereby deposited on an object being fabricated. The release of droplets may be repeated, one layer of droplets at a time, to fabricate the object. Multiple actuators may simultaneously organize droplets in layers. A robot may move the actuators, one at a time, into position for releasing the droplets.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 1, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Udayan Umapathi, Patrick Shin, Hiroshi Ishii
  • Patent number: 10852269
    Abstract: A gas sensor for detecting the concentration of a detection target gas in an atmosphere of interest is disposed on an electrically insulating member. The gas sensor includes an insulating porous layer formed of an electrically insulating porous material, a reference electrode, a solid electrolyte body, a detection electrode that are stacked in this order on the electrically insulating member, and a reference electrode lead disposed between the insulating member and the insulating porous layer. The insulating porous layer defines a through hole in a region sandwiched between the reference electrode lead and the reference electrode. An electrically conductive member formed of a material having electrical conductivity is disposed in the through hole so as to extend from an opening of the through hole at one end thereof to an opening of the through hole at the other end thereof.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 1, 2020
    Assignee: NGK SPARK PLUG CO., LTD.
    Inventors: Tetsuo Yamada, Hitoshi Furuta
  • Patent number: 10852274
    Abstract: A method of target molecule detection includes simultaneously obtaining a first signal from a first working electrode and a second signal from a second working electrode, wherein the first signal is responsive to interaction of the first recognition element with the target molecule in a sample, and the second signal is indicative of background noise from the sample. The method further includes generating a modified signal that is proportional to an instantaneous difference between the first and second signals, wherein the modified signal indicates an amount of the target molecule present in the sample.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: December 1, 2020
    Assignee: Auburn University
    Inventors: Christopher J. Easley, Mark D. Holtan, Subramaniam Somasundaram
  • Patent number: 10845327
    Abstract: A sensor element includes: a sensing cell including a sensing electrode and a reference electrode; an oxygen pump cell configured to pump out oxygen in an internal space when a predetermined voltage is applied between an inner side pump electrode formed facing to the internal space and an outer side pump electrode formed on an outer surface of the sensor element; and a heater capable of heating the sensing cell and the oxygen pump cell. The concentration of a target gas component in measurement gas is specified based on a sensor output generated at the sensing cell and a pump current at the oxygen pump cell while the heater heats the sensing cell to a temperature of 400° C. to 600° C. and heats the oxygen pump cell to a temperature of 580° C. to 850° C. determined in accordance with a diffusion resistance provided to the measurement gas by a gas introduction part.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 24, 2020
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yuki Nakayama, Noriko Hirata, Taku Okamoto, Kosuke Monna
  • Patent number: 10837939
    Abstract: The present disclosure provides a gas sensor element comprising a porous protective layer with improved water repellency upon continuously water pouring, which is a gas sensor element comprising: a detection portion; and a porous protective layer formed around the detection portion, wherein the porous protective layer is formed from an aggregate containing alumina and a coating material containing silica, and in the porous protective layer, the weight concentration x % by weight of the coating material with respect to the total weight of the aggregate and the coating material, and the porosity y %, satisfy the following formula (1): y?0.0058x2?1.2666x+68??(1), and in the porous protective layer, the pore volume of pores having a pore diameter of 100 nm or less is 0.02 mL/g or less.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: November 17, 2020
    Assignees: TOYOTA JIDOSHA KABUSHIKI KAISHA, DENSO CORPORATION
    Inventors: Hiroki Nishijima, Yoshiharu Miyake, Haruki Kondo, Yasushi Hirata, Hirofumi Suzuki, Kei Sugiura, Toru Takeuchi
  • Patent number: 10837936
    Abstract: An electrochemical measurement system includes an electrochemical measurement plate configured to have first and second biological samples placed thereon and an electrochemical measurement device connected to the electrochemical measurement plate. The electrochemical measurement plate includes a first well configured to have the first biological sample placed therein, a first measurement electrode group including first measurement electrodes provided within the first well, a second well configured to have the second biological sample placed therein, and a second measurement electrode group including second measurement electrodes provided within the second well.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: November 17, 2020
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Kaoru Hiramoto, Masahiro Yasumi
  • Patent number: 10830690
    Abstract: The present disclosure relates to a method for manufacturing a sensor cap with at least one main body and a membrane for an optochemical or electrochemical sensor for determining and/or monitoring the concentration of an analyte in a measuring medium, a corresponding sensor cap, and a corresponding sensor. In one aspect of the present disclosure, a permeable membrane is provided with a surface for contacting the measuring medium, as well as a main body with at least one sector for connecting to the membrane. At least part of the membrane and main body are welded, wherein the membrane is at least partially applied to the at least one sector of the main body and a connection between the main body and membrane is sealed against the measuring medium.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: November 10, 2020
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Erik Hennings, Jens Vettermann, Andreas Löbbert
  • Patent number: 10830756
    Abstract: Methods of manufacturing well-controlled nanopores using directed self-assembly and methods of manufacturing free-standing membranes using selective etching are disclosed. In one aspect, one or more nanopores are formed by directed self-assembly with block co-polymers to shrink the critical dimension of a feature which is then transferred to a thin film. In another aspect, a method includes providing a substrate having a thin film over a highly etchable layer thereof, forming one or more nanopores through the thin film over the highly etchable layer, for example, by a pore diameter reduction process, and then selectively removing a portion of the highly etchable layer under the one or more nanopores to form a thin, free-standing membrane.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: November 10, 2020
    Assignee: APPLIED MATERIALS, INC.
    Inventors: Ankit Vora, Kenichi Ohno, Philip Allan Kraus, Zohreh Hesabi, Joseph R. Johnson