Patents Examined by J. G. Mullins
  • Patent number: 4778887
    Abstract: The present invention is related with .alpha.-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneaceton itriles which are effective in destructing or preventing the growth of Protozoa in subjects suffering from such Protozoa.
    Type: Grant
    Filed: October 17, 1986
    Date of Patent: October 18, 1988
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Gustaaf M. Boeckx, Alfons H. M. Raeymaekers, Victor Sipido
  • Patent number: 4772727
    Abstract: A multistage method for producing R-(+)-.alpha.-lipoic acid and S-(-)-.alpha.-lipoic acid (thioctic acid) by reacting a compound of formula II ##STR1## by means of enantioselective epoxidation to the epoxy alcohol of formula III, ##STR2## reduction to 1,3-diol-dihydroxynone-8-ene of formula IV, ##STR3## reaction with a substituted sulfonic acid chloride to 1,3-disulfoxynone-8-ene of formula V, ##STR4## oxidation with ruthenium tetroxide to 6,8-disulfoxyoctanoic acid of formula VI ##STR5## and subsequent reaction with sodium sulfide/sulfur.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: September 20, 1988
    Assignee: Degussa
    Inventors: Ian O. Sutherland, Philip C. B. Page, Christopher M. Rayner
  • Patent number: 4772609
    Abstract: This invention relates to antiviral organic guanidine derivatives compositions; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are tubastrines derived from marine coral tubastrea aurea.
    Type: Grant
    Filed: June 26, 1986
    Date of Patent: September 20, 1988
    Assignee: Harbor Branch Oceanographic Institution, Inc.
    Inventors: Tatsuo Higa, Ryuichi Sakai
  • Patent number: 4769455
    Abstract: The invention relates to new benzodisultams of the general formula (I) ##STR1## in which R.sup.1 represents an optionally substituted radical from the series comprising alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aralkyl and aryl,R.sup.2 represents hydrogen or an optionally substituted radical from the series comprising alkyl, alkenyl, alkinyl and aralkyl, andR.sup.3 represents an optionally substituted and/or optionally fused six-membered aromatic heterocyclic radical which contains at least one nitrogen atom,a process for their preparation and their use as herbicides.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: September 6, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Joachim Diehr, Christa Fest, Rolf Kirsten, Joachim Kluth, Klaus-Helmut Muller, Theodor Pfister, Uwe Priesnitz, Hans-Jochem Riebel, Wolfgang Roy, Hans-Joachim Santel, Robert R. Schmidt
  • Patent number: 4767760
    Abstract: Novel 5,6-dihydro-2-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-diones which are effective in destroying or preventing the growth of Protozoa in subjects suffering from such Protozoa.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: August 30, 1988
    Assignee: Janssen Pharmacuetica N.V.
    Inventors: Gustaaf M. Boeckx, Alfons H. M. Raeymaekers, Victor Sipido
  • Patent number: 4767443
    Abstract: There are described novel, microbicidally active 5-(arylmethylimino)-pyrimidines of the formula I ##STR1## wherein R.sub.n --A-- is an unsubstituted or substituted phenyl, naphthyl, biphenyl, phenoxyphenyl or phenylthiophenyl, and R.sub.1 is an ether, thioether or amino function, these substances being produced according to the invention by substitution of the halogen atom in the claimed intermediates of the formula II ##STR2## The use of these substances in plant protection, and also further important intermediates, are likewise described.
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: August 30, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Helmut Zondler, Wolfgang Eckhardt, Robert Nyfeler
  • Patent number: 4767858
    Abstract: The invention features compounds having anti-arthritic activity and having the formula ##STR1## wherein X is an alkyl group having between 1 and 8, inclusive, carbon atoms and Y is a hydroxyalkylamino group having between 2 and 8, inclusive, carbon atoms; a dialkylamino group having between 2 and 12, inclusive, carbon atoms; a carboxyalkylamino group having between 2 and 9, inclusive, carbon atoms; a heterocycloalkyl group having between 2 and 5, inclusive, carbon atoms and having nitrogen as a hetero atom; an alkylthioalkylamino group having between 3 and 10, inclusive, carbon atoms; or a heteroarylalkylthioalkylamino group having between 5 and 14, inclusive, carbon atoms and having nitrogen as a hetero atom.
    Type: Grant
    Filed: May 14, 1987
    Date of Patent: August 30, 1988
    Assignee: Biomeasure, Incorporated
    Inventor: Sun H. Kim
  • Patent number: 4764622
    Abstract: A light-collecting system, which contains a coumarin derivative of the formula ##STR1## in which T denotes O or NR.sub.4,R.sub.4 represents hydrogen, optionally substituted aryl, cycloalkyl or aralkyl,R.sub.1 denotes a carbocyclic or heterocyclic 5 or 6 membered ring bonded via a C.atom, or a 5 or 6 membered heterocyclic ring which is bonded via a N atom and is rotationally asymmetrical to an axis placed through the coumarin/N-heterocyclic bond, the 5 or 6 membered rings may carry non-ionic substituents and for an optionally substituted benzene ring or naphthalene ring to be fused to the said rings;X signifies ##STR2## or --OR.sub.2 ', R.sub.2 represents hydrogen, alkyl, cycloalkyl, aralkyl or aryl, hydrocarbon radicals may be substituted, andR.sub.3, in addition to having the definitions given for R.sub.2, also signifies a radical of the formulaeR.sub.6 --(X).sub.n --CO-- or R.sub.7 --(X).sub.n --SO.sub.2 --R.sub.6 and R.sub.
    Type: Grant
    Filed: October 17, 1986
    Date of Patent: August 16, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uwe Claussen, Horst Harnisch
  • Patent number: 4761172
    Abstract: Cyclohexenol derivatives of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, X and A have the meanings stated in the description, are used for controlling undesirable plant growth.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: August 2, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Dieter Jahn, Rainer Becker, Michael Keil, Ulrich Schirmer, Winfried Richarz, Bruno Wuerzer, Norbert Meyer
  • Patent number: 4760078
    Abstract: A novel 1,2-dithiol-3-thione derivative which has an immunomodulating property, which is expressed by the formula (I): ##STR1## wherein R denotes hydrogen, halogen, lower alkoxy group, lower alkyl group, amino group, lower alkyl-substituted amino group or lower alkoxycarbonyl group.
    Type: Grant
    Filed: March 5, 1987
    Date of Patent: July 26, 1988
    Assignee: Mitsui Toatsu Chemicals Inc.
    Inventors: Itaru Yamamoto, Akira Matsubara, Kanji Tomiya, Osamu Mizuno, Mitsuhiro Sakaguchi, Mikio Kumakura
  • Patent number: 4756847
    Abstract: Novel compounds which, when used as a components of liquid crystal compositions, have good compatibility with other components and also have large values of dielectric anisotropy and optical anisotropy, and liquid crystal compositions containing the same are provided, which compounds are 4'-cyano-3'-halogenophenyl 4-(5-substituted-pyrimidin-2-yl)benzoate expressed by the formula ##STR1## wherein R represents an alkyl group of 1 to 10 carbon atoms or --(CH.sub.2).sub.m --O--(CH.sub.2).sub.p --CH.sub.3 wherein m and p each represent an integer of 0 to 8 and m+p.ltoreq.8, and X represents a halogen atom.
    Type: Grant
    Filed: January 8, 1986
    Date of Patent: July 12, 1988
    Assignee: Chisso Corporation
    Inventors: Naoyuki Yoshida, Kisei Kitano, Yoshito Furukawa, Tetsuya Ogawa, Shigeru Sugimori, Yasuyuki Goto, Toyoshiro Isoyama, Kazunori Nigorikawa
  • Patent number: 4755528
    Abstract: Disclosed are 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and their N-acyl and N-alkyl derivatives. Also disclosed are processes for preparing the disclosed compounds; pharmaceutical compositions comprising such compounds; and a method of treatment comprising administering such compounds and compositions when an antihypertensive effect or radioprotective effect is indicated.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: July 5, 1988
    Assignee: Alcon Laboratories, Inc.
    Inventors: Mark T. DuPriest, Billie M. York, Jr.
  • Patent number: 4749703
    Abstract: Compounds of the formula: ##STR1## wherein A means an alkylene; Y--Z means ##STR2## --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or ##STR3## R.sub.1 and R.sub.2 are each a substituent; R.sub.3 is hydrogen atom, alkyl, or alkoxy; R.sub.4 is phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl, or phenylsulfonyl; a is 2 or 3, b and c are each 1 or 2, and d is an integer of 0 to 2, provided that the phenyl, phenyl moiety and naphthyl may optionally be substituted, and a pharmaceutically acceptable salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. The compounds and salt thereof show potent calcium antagonistic activity and are useful for prophylaxis and treatment of hypertension and/or ischemic heart disease.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: June 7, 1988
    Assignee: Dainippon Pharmaceutical Co., Ltd.
    Inventors: Hitoshi Uno, Mikio Kurokawa, Fuminori Sato, Naonobu Hatano
  • Patent number: 4748242
    Abstract: The present invention is directed to a process for the production of polyisocyanates containing isocyanurate groups by trimerizing a mixture of aliphatic-cycloaliphatic diisocyanates having a sterically unhindered isocyanate group bound to a primary aliphatic carbon atom and a sterically hindered isocyanate group bound to a tertiary carbon atom which forms a part of a cycloaliphatic ring system and 1,6-diisocyanatohexane. The present invention is also directed to the polyisocyanates containing isocyanurate groups produced according to this process and to their use, optionally in blocked form, as an isocyanate component in the production of polyisocyanate polyaddition products, preferably polyurethane lacquers.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: May 31, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhard Halpaap, Josef Pedain, Hans-Joachim Kreuder, Gerhard Klein, Dieter Arlt
  • Patent number: 4747866
    Abstract: A pirimidinyloxyalkanamide derivative of Formula 1: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkylthio group, a lower alkenylthio group, a lower alkynylthio group, a halogenated lower alkenylthio group, a cycloalkylthio group, an aroxyalkylthio group, a lower alkoxyl group, an amino group, a methanesulfonyl group, a trifluoromethyl group, an anilino group which may be substituted with a halogen atom or a benzylthio group which may be substituted with a halogen atom; R.sub.2 represents a hydrogen atom, a halogen atom, a lower alkyl group, a trifluoromethyl group, an amino group, a lower alkoxy group or a lower alkylthio group; R.sub.3 represents an ethyl group or an n-propyl group; and R.sub.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: May 31, 1988
    Assignee: Ube Industries, Ltd.
    Inventors: Tetsuo Takematsu, Yasutomo Takeuchi, Mitsuaki Takenaka, Seiji Takamura, Hiroshi Hase
  • Patent number: 4747868
    Abstract: The new compounds of the formula I or salts thereof ##STR1## in which R denotes a (substituted) cyclohexyl radical or a (substituted) cyclohexenyl radical; and Y denotes cyano, a (substituted) (di)(thio)carboxylic acid (ester), carboxamide or acetal radical, a keto or oxime radical or a heterocyclic radical, possess an advantageous action as plant growth-regulators and, in addition, have favorable herbicidal and fungicidal properties.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: May 31, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Roland Schmierer, Hilmar Mildenberger, Reinhard Handte, Helmut Burstell, Burkhard Sachse, Klaus Bauer, Hermann Bieringer
  • Patent number: 4746738
    Abstract: Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcmenet of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a proplylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula ##STR1## wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, R.sup.a =H is aryl or substituted aryl, R.sup.b =H, denotes aryl or substituted aryl and R.sup.c -H, represents alkyl or aryl, provided that R.sup.
    Type: Grant
    Filed: March 24, 1987
    Date of Patent: May 24, 1988
    Assignee: Wella Aktiengesellschaft
    Inventors: Wolfgang Hanefeld, Rudi Rothlisberger, Friedrich Noser
  • Patent number: 4745111
    Abstract: Compounds of the formula ##STR1## where R and A have the meanings given in the description, and their use in the treatment of disorders are described.
    Type: Grant
    Filed: July 9, 1986
    Date of Patent: May 17, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Hans-Juergen Teschendorf, Liliane Unger
  • Patent number: 4739050
    Abstract: This invention relates to 2-arylbenzothiazine derivatives of the formula[I] and salts thereof, process of preparation and therapeutic drug comprising them for circulatory diseases, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are hydrogen, lower alkyl, hydroxy, lower alkoxy, acyloxy, tetrahydropyranyloxy, halogen, nitro, amino, lower alkylamino or ##STR2## and the lower alkoxy group may be substituted by halogen, formyl, lower alkoxy or epoxy;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is hydrogen, lower alkyl, cycloalkyl, hydroxy, lower alkoxy, mercapto, lower alkylthio, arylthio, halogen, cyano, formyl-lower alkyl, lower alkoxy-lower alkyl or ##STR3## R.sup.5,R.sup.6,R.sup.7 and R.sup.
    Type: Grant
    Filed: November 4, 1986
    Date of Patent: April 19, 1988
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Iwao Jun-ichi, Iso Tadashi, Oya Masayuki
  • Patent number: 4737514
    Abstract: Compounds of formula (I) ##STR1## wherein n is 0, 1 or 2;one or R.sup.1 and R.sup.2 is hydrogen and the other is selected from carbamoyl, N-C.sub.1-4 alkylcarbamoyl, N,N-di-C.sub.1-4 alkylcarbamoyl, carbamimidoyl, N.sup.1 -C.sub.1-4 alkylcarbamimidoyl, N.sup.2 -C.sub.1-4 alkylcarbamimidoyl, N.sup.1 -C.sub.1-4 alkyl-N.sup.2 -C.sub.1-4 alkylcarbamimidoyl, N.sup.1,N.sup.1 -di-C.sub.1-4 alkylcarbamimidoyl, N.sup.1,N.sup.1 -di-C.sub.1-4 alkyl-N.sup.2 -C.sub.1-4 alkylcarbamimidoyl and imidazolin-2-yl (optionally substituted by one or more C.sub.1-4 alkyl groups); andR.sup.3 is selected from hydrogen, saturated and unsaturated aliphatic hydocarbon moieties containing from 1 to 4 carbon atoms, groups OR.sup.4 (where R.sup.4 is selected from hydrogen and saturated and unsaturated aliphatic hydrocarbon moieties containing from 1 to 4 carbon atoms), halo, groups of formula--NR.sup.5 R.sup.6 (where R.sup.5 and R.sup.6 are independently selected from hydrogen, C.sub.1-4 alkyl and hydroxy C.sub.
    Type: Grant
    Filed: January 2, 1986
    Date of Patent: April 12, 1988
    Assignee: Burroughs Wellcome Co.
    Inventors: Morton Harfenist, Charles T. Joyner, Darryl J. Heuser