Patents Examined by J. Haley
  • Piperidine compounds and pharmaceutical compositions thereof
    Patent number: 4985446
    Abstract: Novel piperidine compounds having the formula ##STR1## wherein R.sup.3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.3-8 -cycloalkyl, C.sub.3-5 -alkylene or aralkoxy,R.sup.1 is straight or branched C.sub.1-8 -alkyl, C.sub.4-8 -alkoxy-C.sub.4-8 -alkyl, C.sub.4-7 -cycloalkyl, aryloxy-C.sub.3-8 -alkyl, C.sub.4-8 -alkenyl, or C.sub.4-8 -cycloalkylalkyl, or R.sup.1 may also be hydrogen or C.sub.1-3 -alkyl, when R.sup.3 is aryl, which is substituted with two or more of C.sub.1-6 -alkyl, C.sub.1-6 alkoxy, C.sub.3-8 -cycloalkyl, aralkoxy, or with C.sub.3-5 -alkylene.X is hydrogen or halogen, and whereinY is O or Sor a salt thereof with a pharmaceutically-acceptable acid, pharmaceutical compositions thereof, method-of-treating therewith.The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: January 15, 1991
    Assignee: A/S Ferrosan
    Inventors: Jorgen Drejer, Palle Jakobsen
  • Control of isomer distribution in a chlorination process
    Patent number: 4939263
    Abstract: The relative amounts of 5,6-dichloro-2-(trichloromethyl)pyridine and 3,6-dichloro-2-(trichloromethyl)pyridine obtained in the chlorination of 2-chloro-6-(trichloromethyl)pyridine in the liquid phase at temperatures of about 160.degree. C. to about 220.degree. C. and in the presence of a metal halide catalyst, such as ferric chloride, are controlled by regulating the amount of hydrogen chloride present in the system, adding hydrogen chloride to obtain a mixture enriched in 5,6-dichloro-2-(trichloromethyl)pyridine or removing hydrogen chloride, usually by passing excess chlorine or an inert gas through the system, to obtain a mixture enriched in 3,6-dichloro-2-(trichloromethyl)pyridine.
    Type: Grant
    Filed: September 28, 1989
    Date of Patent: July 3, 1990
    Assignee: The Dow Chemical Company
    Inventors: Richard K. Helling, Philip D. Grover, Thomas J. Dietsche, Mark L. Garibaldi
  • 1-aminomethyl-3-aryl-4-cyano-pyrroles
    Patent number: 4935416
    Abstract: Fungicidally active novel 1-aminomethyl-3-aryl-4-cyano-pyrroles of the formula ##STR1## in which AR represents optionally substituted phenyl.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: June 19, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Detlef Wollweber, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler
  • Process for the preparation of unsymmetrical dihydropyridines
    Patent number: 4904789
    Abstract: In the preparation of nitrenedipine by reaction of an ylidene compound of the formula ##STR1## with an enamine compound of the formula ##STR2## the improvement which comprises effecting the reaction in the presence of a catalytic amount of diisopropylamine acetate or dimethylbenzylamine acetate. The product is produced in high yield with reduced amounts of symmetrical by-products.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: February 27, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Paul Naab, Willi Lange, Werner Teller