Patents Examined by J. Hines
  • Patent number: 10081672
    Abstract: The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: September 25, 2018
    Assignee: National Research Council of Canada
    Inventors: Wei-Gang Hu, Laurel M. Negrych, Damon Chau, Junfei Yin, Scott J. Jager, John W. Cherwonogrodzky
  • Patent number: 10077460
    Abstract: The majority of clinically used antibiotics and anticancer agents are derived from bacterial small molecules. These molecules are produced by dedicated biosynthetic gene clusters, sets of genes that are responsible for the step-wise generation of the target small molecule. Recent investigations have indicated, to the surprise of many experts, that the majority of these biosynthetic genes are inactive or ‘silent’ for unknown reasons. Thus under typical bacterial culturing conditions, these genes are not expressed and consequently the bioactive small molecule products are not synthesized. Disclosed is a method for high throughput screening of elicitors of cryptic metabolites, a method for producing cryptic metabolites, and a new family of cryptic metabolites, the acybolins, as well as their complete structural elucidation.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: September 18, 2018
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventor: Mohammad R. Seyedsayamdost
  • Patent number: 10036073
    Abstract: The present invention relates to a slide chip for a sensor for detection of food-borne bacteria and a fabrication method thereof. More particularly, the invention relates to a slide chip for a sensor for detection of food-borne bacteria and a fabrication method thereof, the slide chip comprising: a substrate coated with a metal; a linker having a substituent which may be bonded to the metal and is located at the 5? end of deoxythymidine (dT); and a food-borne bacterium-derived RNA aptamer that is bound to the linker by the 3?-end poly A tail. The slide chip makes it possible to detect food-borne bacteria in a rapid and accurate manner.
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: July 31, 2018
    Assignee: KOREA FOOD RESEARCH INSTITUTE
    Inventors: Young Jin Cho, Chul Jin Kim, Nam Soo Kim, Chong Tai Kim, Jin Soo Maeng, Tae Eun Kim, Myung Hyun Lee
  • Patent number: 9982040
    Abstract: The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof as well as their use in therapy or prophylaxis.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 29, 2018
    Assignee: Her Majesty The Queen in Right of Canada, As Represented by the Minister of National Defence
    Inventors: Wei-Gang Hu, Laurel M. Negrych, Damon Chau, Junfei Yin, Scott J. Jager, John W. Cherwonogrodzky
  • Patent number: 9943597
    Abstract: Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: April 17, 2018
    Assignee: Immuron Limited
    Inventors: Yaron Ilan, Gadi Lalazar, Tomer Adar, Meir Mizrahi, Ami Ben-Ya'acov
  • Patent number: 9902947
    Abstract: The invention is directed to means, based on CyaA-carried polypeptide(s), for use in the immunotherapeutic treatment of first determined pathological condition(s) diagnosed in a mammalian host by eliciting a T cell immune response against a first group of epitopes contained in said polypeptide(s) and in the prophylaxis against second determined pathological condition(s) in the same mammalian host by eliciting a T cell memory immune response against a second group of epitopes contained in said polypeptide(s), said immune responses being obtained after administration of said vector-carried polypeptide(s) into said host, wherein said prophylaxis against second determined pathological condition(s) is not observed when said second group of epitopes is not contained in said administered vector-carried polypeptide(s).
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: February 27, 2018
    Assignee: GENTICEL
    Inventors: Michael Esquerré, Marie Momot, Anne Goubier, Yolande Misseri
  • Patent number: 9889185
    Abstract: The subject matter disclosed herein pertains to the modulation of a bacterial invasion switch and the subsequent use of the bacterium to vaccinate an organism. In one embodiment, the bacterial invasion switch is modulated by changing the proteolysis of ExoR protein. In another embodiment, a mutated bacterium produces a mutant ExoR protein that resists proteolysis.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: February 13, 2018
    Assignee: Research Foundation of the City University of New York
    Inventors: Haiping Cheng, Shari Walcott, Haiyang Lu, Li Luo, Menghua Yang, Zahra Salehi
  • Patent number: 9884101
    Abstract: The present invention relates to recombinant fragments of Plasmodium polypeptides and polynucleotides encoding same. The invention further relates to compositions comprising the recombinant fragments of Plasmodium polypeptides and their use in the treatment and prevention of malaria.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: February 6, 2018
    Assignee: The Walter and Eliza Hall Institute for Medical Research
    Inventors: Lin Chen, Alan Cowman, Tony Triglia
  • Patent number: 9844587
    Abstract: Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: December 19, 2017
    Assignee: St. Jude Children's Research Hospital
    Inventors: Elaine Tuomanen, Elizabeth R. Mann
  • Patent number: 9795640
    Abstract: A method for treating obesity, insulin sensitivity, and related conditions involves administering to the subject a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE). A composition includes a bacterium for overexpressing a N-acyl-phosphatidylethanolamine (NAPE) and/or a N-acylethanolamine (NAE); and an ingestible vehicle in which the bacterium is provided.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: October 24, 2017
    Assignee: Vanderbilt University
    Inventors: Sean S. Davies, Zhongyi Chen, Lilu Guo, Yongqin Zhang
  • Patent number: 9784753
    Abstract: Preparations containing deep-frozen blood are used for test procedures for determining blood response.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: October 10, 2017
    Inventors: Albrecht Wendel, Thomas Hartung
  • Patent number: 9757445
    Abstract: The present invention provides attenuated P. multocida strains that elicit an immune response in animal P. multocida, compositions comprising said strains, methods of vaccination against P. multocida, and kits for use with such methods and compositions. The invention further provides novel, genetically-engineered mutations in P. multocida hyaD and nanPU genes, which are useful in the production of novel attenuated P. multocida bacterial strains.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 12, 2017
    Assignee: MERIAL INC.
    Inventors: Paulraj Kirubakaran Lawrence, Russell F. Bey
  • Patent number: 9745563
    Abstract: The present invention relates to a mutant microbial host cell which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide having ?-amylase activity AmyC or an homologous thereof. It has been surprisingly found that when the mutant microbial host cell according to the invention is used in a method to produce a compound of interest, for example an enzyme, an improved purity of the product is obtained.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: August 29, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Noel Nicolaas Maria Elisabeth Van Peij, Martina Beishuizen, Peter Jozef Ida Van De Vondervoort
  • Patent number: 9657103
    Abstract: The present invention relates to methods of treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection a subject that involves administering a CD11b inhibitor. The present invention further relates to a non-human transgenic animal expressing human CD11b and its use in methods of identifying novel therapeutics for the treatment and prevention of Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 23, 2017
    Assignee: New York University
    Inventors: Victor J. Torres, Ashley L. Dumont
  • Patent number: 9624515
    Abstract: An isolated fungus is described. The isolated fungus produces at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1, 4-cyclohexadiene, and (+)-?-methylene-?-fenchocamphorone. A method for producing at least one compound selected from the group consisting of 1,8-cineole, 1-methyl-1, 4-cyclohexadiene, and (+)-?-methylene-?-fenchocamphorone is also described. The method includes culturing a fungus on or within a culturing media in a container under conditions sufficient for producing the at least one compound.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: April 18, 2017
    Inventors: Gary A. Strobel, Angela R. Tomsheck
  • Patent number: 9593313
    Abstract: The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kDa glutathione S-transferase protein from a schistosome selected from Schistosoma haematobium, Schistosoma mansoni, Schistosoma bovis represented respectively by the sequences SEQ ID NO: 1, SEQ ID NO: 2 and SEQ ID NO: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type Th1 and/or Th17.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: March 14, 2017
    Assignees: UNIVERSITE DU DROIT ET DE LA SANTE DE LILLE 2, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE
    Inventors: Monique Capron, Mohamed El Nady, Jean-Frederic Colombel, Gilles Riveau
  • Patent number: 9561268
    Abstract: The present invention relates to immunogenic compositions comprising one or more Streptococcus pneumoniae capsular saccharide conjugates and a protein component comprising Protein E and/or PilA from Haemophilus influenzae.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 7, 2017
    Assignee: GlaxoSmithKline Biologicals, S.A.
    Inventors: Francesca Ceddia, William Paul Hausdorff, Vincent Verlant, Carine Ysebaert
  • Patent number: 9562894
    Abstract: Methods for detecting in a sample the presence of an antibody to a conjugate of an antigen associated with a first carrier by a first association are disclosed. The method comprises contacting a conjugate of the antigen associated with a second carrier by a second association with said sample under conditions that allow binding of the antibody to the antigen; and introducing an agent to detect the presence of the antibody bound to said antigen. The first association and the second association are covalent associations and the first association is different from the second association. Also provided are kits, multiwell plates and conjugates that are useful in the method and further uses of the method. Also provided is a method of releasing a batch of a vaccine comprising a conjugate of an antigen associated with a first carrier by a first association and antibodies useful in this method.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: February 7, 2017
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Francesco Berti, Carl E. Frasch
  • Patent number: 9539290
    Abstract: An individualized bacterial treatment of cancer is provided. The treatment includes a strain of bacteria modified by in-vivo passage through tumor grafts in experimental animals, where the modified strain exhibits enhanced cancer cell-targeting of a specific malignancy arising in a unique individual to the corresponding parent strain of bacteria. The treatment uses this modified strain for the treatment human solid-tumor malignancies by inoculating an individual with a quantity of the strain; and repeating inoculations at periodic intervals where repeated inoculations tend to progressively eliminate the solid tumor malignancy in the individual.
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: January 10, 2017
    Assignee: AntiCancer Inc.
    Inventors: Ming Zhao, Fuminari Uehara
  • Patent number: 9452206
    Abstract: The present invention includes a method and device for the isolation of lymphocytes, particularly splenic lymphocytes, for administration to patients. In particular for patients undergoing a splenectomy, administration of splenic lymphocytes may increase a patient's immunity and reduce the likelihood of post-splenectomy infections and other complications.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: September 27, 2016
    Assignee: CHILDREN'S HOSPITAL OF ORANGE COUNTY
    Inventor: Mustafa Kabeer