Abstract: The present invention provides an anti-PD-L1 antibody capable of staining tumor cells such as melanoma cells. An anti-PD-L1 antibody comprising (a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and (b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDP (SEQ ID NO: 5). A composition for detecting PD-L1, comprising the above antibody as an active ingredient. A method for preparing the above antibody is also provided.
Type:
Grant
Filed:
October 28, 2020
Date of Patent:
July 11, 2023
Assignees:
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.
Abstract: A system for subsurface transmission includes an array of very low frequency (VLF) transmitter nodes supported by semi-autonomous maritime, airborne, or space platforms spaced at regular intervals from their nearest neighbors and phased to localize VLF coverage to some desired area on a body of water.
Abstract: An apparatus, method and computer program product is disclosed. The apparatus may comprise means for receiving a performance metric for an antenna array comprised of a plurality of radiating elements, the performance metric being based on performance data associated with the antenna array, the antenna array having a radiating configuration represented by configuration parameters. The apparatus may also comprise means for updating the configuration parameters dependent on the received performance metric by means of estimating new configuration parameters for moving the performance metric towards a target value. The apparatus may also comprise means for re-configuring the radiating configuration of the antenna array based on the updated configuration parameters such that the physical geometry of the antenna array is changed.
Abstract: A lens antenna array system for wireless communication is provided that includes a lens antenna array transmitter having a first lens and a lens antenna array receiver having a second lens. The lens antenna array transmitter transmits a plurality of RF signals across a plurality of near-field communication links to the lens antenna array receiver.
Abstract: Proactive caching, at a client device (e.g., a feature phone), of transient assistant action suggestions for selective rendering by an assistant client application of the client device. A transient assistant action suggestion, when rendered via an assistant client application and selected, causes the assistant client application to initiate performance of a corresponding assistant action. In various implementations, a prefetched transient action suggestion can be a time-constrained suggestion that includes at least associated rendering restriction metadata that defines one or more temporal windows to which rendering of the time-constrained suggestion is restricted. Proactive cache refresh rate metadata can also be associated with transient action suggestion(s) and defines a duration during which the assistant client application is to refrain from interfacing with a remote system to prefetch updated transient assistant action suggestions.
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
July 4, 2023
Assignee:
GOOGLE LLC
Inventors:
Diego Accame, Siddharth Jain, Bartlomiej Borawski, Yujie Wan
Abstract: The basic idea of this invention is to send one or more cubesats into orbit, each equipped with a hardware security module. Users would send their transaction to the cubesats which would collect them into blocks, sign them, and send (bounce) them back to earth (and to one another). Bounce Blockchain provides scalability through sharding (transactions will be partitioned over cubesats). Because modern hardware security modules are tamper-resistant (become inoperable if tampered with) or tamper-responsive (erase their keys if tampered with), take their keys from physical processes, and have been validated, socio-technical protocols can ensure that it is infeasible to forge the identity of a hardware security module in a cubesat with another cubesat. If, however, some cubesats are destroyed, the blockchain will continue to execute correctly though some transactions will be lost. New cubesats can be sent up in short order as they are quite cheap to launch.
Abstract: A module for a base station monopole has a wall defining an interior space. The wall includes an opening configured to receive electronic equipment and a vent opening in communication with the exterior of the module. A reinforcement member is secured to the wall and is positioned opposite to the opening and adjacent the vent opening. A baffle is supported adjacent the wall where the baffle has an intake opening and an exhaust opening in communication with the vent opening. The intake opening is laterally offset from the exhaust opening.
Type:
Grant
Filed:
April 9, 2021
Date of Patent:
June 27, 2023
Assignee:
CommScope Technologies LLC
Inventors:
Richard Williams, Jignesh Patel, Ulrich Gienger
Abstract: A wetmate connector for wirelessly communicating data or power signals between first and second components includes a first connector half which is mountable to the first component and a second connector half which is mountable to the second component. The first connector half includes a first internal cavity and a first wireless communications device which is positioned in the first internal cavity. The first wireless communications device is operable to transmit or receive wireless data and/or power signals, and the first internal cavity is sealed from an external environment at least when the first connector half is mounted to the first component. The second connector half includes a second internal cavity and a second wireless communications device which is positioned in the second internal cavity.
Abstract: The disclosure relates to techniques for controlling Specific Absorption Rate (SAR) of radio energy transmission. In particular, the disclosure relates to a radio device and a method for controlling radio energy transmission of a plurality of radio entities to comply with a predefined SAR requirement. Such a radio device includes: a plurality of radio entities configured to transmit radio energy; and a controller configured to control the radio energy transmission of the plurality of radio entities to comply with a predefined Specific Absorption Rate, SAR, requirement, wherein the controller is configured to enable at least two radio entities of the plurality of radio entities operating concurrently based on a shared SAR transmission power restriction which allows the at least two radio entities transmitting concurrently at a predefined duty cycle, in particular at 100% duty cycle, without violating the SAR requirement.
Abstract: Gene expression signatures and pathways associated with tuberculosis are identified. The invention provides for diagnostic assays based on gene markers and cell composition, as well as therapeutic targets for modulating tuberculosis infection. In addition, tuberculosis copy number contained in cells and methods of detecting high and low copy number are disclosed.
Abstract: The present invention provides a composition comprising a co-culture of at least two distinct bacterial families, having differing growth and/or proliferative conditions. In some embodiments, the composition comprises a plurality of bacterial genera with high similarity to microbial flora.
Type:
Grant
Filed:
July 6, 2021
Date of Patent:
June 20, 2023
Assignee:
MYBIOTICS PHARMA LTD.
Inventors:
David Baram, David Daboush, Rachel Diamant
Abstract: Provided are a method for preventing, improving, or treating a neurological disorder, mental disorder, senescence, or symptoms thereof, comprising administering to a subject in need thereof vesicles derived from Lactobacillus paracasei as an active ingredient, and a pharmaceutical or functional food composition comprising the vesicles.
Abstract: Disclosed is a composition for promoting local muscle growth or slowing down or preventing local muscle atrophy, which composition contains a polypeptide in the C2 region of the enterotoxin Staphylococcus aureus and a myostatin polypeptide. By means of the composition, the defect in the prior art of only systemic muscle growth being possible has been overcome so as to achieve effects of promoting local muscle growth, or slowing down or preventing local muscle atrophy.
Abstract: Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods.
Type:
Grant
Filed:
February 4, 2022
Date of Patent:
June 13, 2023
Assignee:
The Regents of the University of California
Abstract: A system for reflecting an RF signal comprises a plurality of antenna units (2) configured to receive and passively reflect the RF signal, and a reference antenna (6?). Each antenna unit (2) comprises a respective phase shifter (8) operable to adjustably impose a phase change on the RF signal before reflection. The system may be a Large Intelligent Surface (LIS) and the antenna units may be included in an arrangement of separate panel devices. A control system (20) is configured to operate the respective phase shifter (8) to phase align a first analog antenna signal (ASn) with a first analog reference signal (REF), which are received by the respective antenna unit (2) and the reference antenna (6?), respectively, in response to a first RF signal; determine, for the respective phase shifter (8), a first phase setting resulting in phase alignment, and store the first phase setting.
Type:
Grant
Filed:
May 5, 2020
Date of Patent:
June 6, 2023
Assignee:
Sony Group Corporation
Inventors:
Erik Bengtsson, Fredrik Rusek, Olof Zander
Abstract: A modular, wearable electronic system is disclosed. The modular, wearable electronic system can include an eyewear unit which can be worn on a user's head and one or more modular units which can removably couple with the eyewear unit via one or more ports and/or connectors. The eyewear unit and the modular unit can communicate with each other via the port or connector to which the eyewear unit and the modular unit are coupled. The modular units can supplement the functionality of the eyewear unit.
Type:
Grant
Filed:
October 26, 2021
Date of Patent:
June 6, 2023
Assignee:
Oakley, Inc.
Inventors:
Christopher John Anderson, Benjamin John Meunier, Ryan Neil Saylor, Timothy James Wilde
Abstract: A support has a first surface and a second surface, and directions of normal vectors of the first surface and the second surface pointing outside are different from each other. A first antenna is provided on the first surface, and a second antenna is provided on a second surface. A radio frequency signal received at the first antenna is transmitted through a transmission line to the second antenna, and a radio frequency signal received at the second antenna is transmitted through the transmission line to the first antenna. The first antenna, the second antenna, and the transmission line are configured such that the directivity of the first antenna is different from the directivity of the second antenna.
Abstract: Embodiments of a composition comprising three or four Bacillus species selected from Bacillus amyloliquefaciens, Bacillus subtilis, Bacillus licheniformis and Bacillus coagulans are disclosed. The composition may further comprise, or be used in combination with, feed and/or feed supplements, including feed supplements comprising Yucca, Quillaja, silica, mineral clay, glucan, mannans, or combinations thereof. Also disclosed is a method of administering the composition and/or combination to animals, such as poultry.
Abstract: The present invention is directed to a composition comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic agent, a nucleic acid encoding a fusion polypeptide comprising at least one fibronectin binding polypeptide (FnBP) linked to at least one diagnostic or therapeutic polypeptide agent as well as a corresponding recombinant vector and host cell comprising such a nucleic acid and preferably expressing said fusion polypeptide. The invention also relates to a kit of parts comprising at least one fibronectin binding polypeptide (FnBP), at least one diagnostic or therapeutic agent, and optionally one or more chemical agents for linking the fibronectin binding polypeptide (FnBP) to the diagnostic or therapeutic agent.
Type:
Grant
Filed:
June 14, 2017
Date of Patent:
May 16, 2023
Assignees:
ETH ZURICH, PAUL SCHERRER INSTITUT
Inventors:
Mamta Chabria, Alessandra Moscaroli, Simon Arnoldini, Samuel Hertig, Viola Vogel, Martin Behe, Roger Schibli