Abstract: This invention relates to combination therapy for the treatment of benign prostatic hyperplasia comprising an alpha-1a antagonist and an endothelin antagonist. More specifically, the use of a selective alpha-1a adrenergic receptor antagonist in combination with a subtype non-selective endothelin antagonist provides relief of lower urinary tract symptoms in patients with symptomatic prostatism or benign prostatic hyperplasia. This combination therapy improves lower urinary tract symptoms including increasing urine flow rate, decreasing residual urine volume and improving overall obstructive and irritative symptoms in patients with benign prostatic hyperplasia or symptomatic prostatism.

Abstract: Cancer in a mammal can be treated or prevented by administering to a mammal in need thereof a cancer inhibiting amount of metabolite(s) of &agr;-linolenic acid, such as stearidonic acid (18:4 n-3), eicosatetraenoic acid (20:4 n-3), docosaptentaenic acid (22:5 n-3) and mixtures thereof, especially metabolites including stearidonic acid.

Abstract: A method for minimizing the weight gain side effect associated with Valproate treatment is disclosed. In this method, Metformin, a biguanide compound, is concurrently administered to a patient taking the Valproate therapy. A pharmaceutical composition containing the combination of Valproate and Metformin is also disclosed.

Abstract: A liquid crystal display unit includes a first and a second substrate. A plurality of tiny projections are formed on the first substrate in a scattered arrangement. The tiny projections each have a generally semi-spherical configuration. Top portions of the projections each having a convexly curved surface are contacted with the second substrate, thereby a gap for filling a liquid crystal being formed between the first substrate and the second substrate. The tiny projections are formed by projecting a laser beam to the first substrate.