Abstract: A process is disclosed for producing diphenylalkanes, which process comprises the formation of a reaction mass comprising a (1) solvent, (2) iron, (3) copper, Cu(I) salt or a mixture thereof, and (4) phenylalkylhalide, and maintaining this reaction mass at a temperature of at least 40.degree. C. until diphenylalkane is formed.
Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, R.sub.2 is methyl or ethyl, and A,B,C and D rings optionally containing at least one double bond and optionally substituted with at least one member of the group consisting of optionally protected --OH, .dbd.O, alkyl and alkoxy of 1 to 4 carbon atoms, halogen and alkenyl and alkynyl of 2 to 4 carbon atoms, R is selected from the group consisting of halogen, --OH, alkylthio and alkoxy of 1 to 6 carbon atoms, aralkoxy, arylthio and aralkylthio of 7 to 15 carbon atoms and ##STR2## R.sub.3 and R.sub.4 are individually hydrogen, or alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 15 carbon atoms or taken together with the nitrogen form a heterocycle optionally containing another nitrogen or oxygen atom, excepting the product in which R is methoxy, R.sub.1 and R.sub.2 each represent methyl, A ring carries a 3.beta.-acetoxy function and B ring contains a double bond in 5(6) useful as intermediates for the preparation of 20-keto-pregnanes.
Abstract: Formulae, means, and methods for the sublingual ingestion of natural Progesterone comprising milling and blending natural Progesterone such that it can be absorbed by the sublingual mucosae of a patient and applying it to said sublingual mucosae in a form which permits such absorption.
Abstract: Bicyclic and monocyclic terpenes are oligomerized by contact over a zeolite catalyst to produce high boiling lube oil traction fluid having a high traction coefficient. The traction fluid comprises dimers, trimers and tetramers of the bicyclic and monocyclic terpenes. The lube oil is catalytically hydrogenated to obtain a saturated cycloparaffin hydrocarbon oil traction fluid.
Type:
Grant
Filed:
December 22, 1988
Date of Patent:
May 1, 1990
Assignee:
Mobil Oil Corporation
Inventors:
Catherine S. H. Chen, Thomas R. Forbus, Jr.
Abstract: Alkyl groups in trialkyl aluminum are displaced by .alpha.-olefins in the presence of a nickel catalyst. The displaced alkyl group evolve as .alpha.-olefins. The displacement is fast and the catalyst is then poisoned with a catalyst poison such as lead to prevent undesired side reactions such as isomerization of .alpha.-olefins to internal olefins or dimerization to vinylidene olefins.
Abstract: A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.
Abstract: The present invention concerns a catalyst for alkylation of alkyl aromatics with olefins, i.e. alkylating toluene, a procedure for the production of the catalyst, and a procedure for carrying out the alkylating of the toluene. The catalyst system contains sodium oxide (Na.sub.2 O) on a potassium carbonate (K.sub.2 CO.sub.3) carrier, preferably at about 10 to 70%.
Abstract: Alumina-composited zeolite catalysts are activated by contact with an aqueous ammonium solution under ammonia gas pressure such that a pH of at least about 8 is maintained in the solution. The treated zeolite may thereafter be calcined without prior ammonium-exhange to provide the zeolite in the hydrogen form. Catalysts which are activated in this manner are useful for converting alcohols and/or ethers to hydrocarbons including aromatics.
Type:
Grant
Filed:
February 15, 1989
Date of Patent:
March 27, 1990
Assignee:
Mobil Oil Corporation
Inventors:
Clarence D. Chang, Cynthia T-W. Chu, Carol S. Lee
Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.
Type:
Grant
Filed:
December 1, 1987
Date of Patent:
March 20, 1990
Assignee:
SmithKline Beckman Corporation
Inventors:
Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
Abstract: Methods of modulating the clearance of antibody-coated cells from the circulation of mammals are disclosed. A compound having the formula ##STR1## wherein R and R.sub.1 individually are hydrogen or taken together form a double bond;R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen or hydroxyl; and R.sub.4 is hydrogen or hydroxyl is administered in an amount effective to modulate the clearance of antibody-coated cells from the bloodstream of the mammals.
Type:
Grant
Filed:
February 24, 1988
Date of Patent:
March 13, 1990
Assignee:
Trustees of The University of Pennsylvania
Abstract: A novel ligand for use in hydroformylation reactions wherein at least one olefin having from 2 to 20 carbon atoms is contacted in a reaction zone at a temperature of from about 20.degree. C. to about 250.degree. C. and a pressure of from about 50 psig to about 800 psig with hydrogen, carbon monoxide, and a catalyst containing rhodium, the ligand having the formula ##STR1## wherein: n is 1-4;each R is independently selected from hydrogen, alkyl, alkoxy, aryloxy, aryl, aralkyl, alkaryl, alkoxyalkyl, cycloaliphatic, halogen, alkanoyl, alkanoyloxy, alkoxycarbonyl, carboxyl or cyano;each R.sub.1 and R.sub.2 is independently selected from alkyl, aryl, aralkyl, alkaryl or cycloaliphatic;each R.sub.3 and R.sub.4 is independently selected from hydrogen and the R.sub.1 substituents; andeach Y is independently selected from the elements N, P, As, Sb and Bi.
Type:
Grant
Filed:
March 13, 1989
Date of Patent:
February 27, 1990
Assignee:
Eastman Kodak Company
Inventors:
Thomas J. Devon, Gerald W. Phillips, Thomas A. Puckette, Jerome L. Stavinoha, Jeffrey J. Vanderbilt
Abstract: Herein is described an ocular composition comprising an ocular decongestant such as phenylephrine and certain labdane derivatives which are intraocular pressure lowering agents. The composition not only markedly reduces the ocular reddening otherwise produced by such labdane compounds, but also unexpectedly prolongs and frequently potentiates their intraocular pressure lowering effect. Both of these effects are very beneficial to the use of such labdanes for the treatment of glaucoma.
Abstract: Diphenylamine which is unsubstituted or substituted by alkyl or alkoxy groups can be prepared by treating appropriately substituted dicyclohexylamine with 1-10 bar of H.sub.2 over catalysts containing 0.05-5% by weight of rhodium at 250.degree.-450.degree. C. In addition to rhodium, the catalysts contain at least one other platinum metal from the group consisting of palladium, platinum and iridium on a support containing the noble metals in a total amount of 0.05-5% by weight, the percentage by weight of rodium with respect to all noble metals being 10-90%, and furthermore containing additives of 1-6% by weight of an alkali metal hydroxide and 1-6% by weight of an alkali metal sulphate. All percentages are based on the total weight of the catalyst.
Abstract: Clearance of antibody-coated cells from the circulation of mammals is inhibited by administering an effective amount of 17-hydroxyprogesterone or 16-methylprogesterone. The compounds are useful in treating autoimmune disease.
Abstract: A zootechnical association comprising (a) a zootechnical composition containing a beta adrenergic and (b) a zootechnical composition containing a steroid of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, optionally unsaturated alkyl of 1 to 6 carbon atoms wherein one of the carbon atoms may be replaced by --O-- and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and a method increasing the weight and quality of meat of animals by administration simultaneously, separately or spread out over a period of time.
Abstract: Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.
Abstract: A novel medicine containing isoliquiritigenin as the active ingredient is disclosed, which exhibits excellent effects when used as a medicine for the therapy and prevention of kidney diseases, a medicine for the therapy and prevention of liver diseases, and a medicine for the therapy and prevention of complication resulting from diseases of these organs.
Type:
Grant
Filed:
December 23, 1987
Date of Patent:
February 6, 1990
Assignees:
Dainippon Ink and Chemicals, Inc., Nippon Hypox Laboratories Incorporated
Abstract: Novel antitussive and anesthesic liquid compositions of matter for oral use comprising an effective oral antitussive drug and phenol, and method of using same.
Abstract: A process for producing a steroid compound which is useful as an intermediate for synthesizing plant growth regulators, brassinosteroids, and is represented by the general formula (4): ##STR1## in which R.sub.2 is a methyl or ethyl, and * indicates the binding site of R.sub.1 to a steroid nucleus, or general formula (5): ##STR2## wherein R.sub.1 is as defined above. According to the process disclosed herein, an intermediate for a brassinolide, epibrassinolide, homobrassinolide or derivatives thereof can be produced highly advantageously in the industries.